Research progress on the correlation between gut microbiota and preeclampsia: microbiome changes, mechanisms and treatments
Preeclampsia is a specific disease during pregnancy and is a significant factor in the increased mortality in perinatal women. Gut microbiota, an intricate and abundant microbial community in the digestive tract, is crucial for host metabolism, immunity, and nutrient absorption. The onset and progre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1256940/full |
| _version_ | 1797644326651559936 |
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| author | Yichi Zong Xuguang Wang Jun Wang |
| author_facet | Yichi Zong Xuguang Wang Jun Wang |
| author_sort | Yichi Zong |
| collection | DOAJ |
| description | Preeclampsia is a specific disease during pregnancy and is a significant factor in the increased mortality in perinatal women. Gut microbiota, an intricate and abundant microbial community in the digestive tract, is crucial for host metabolism, immunity, and nutrient absorption. The onset and progression of preeclampsia are closely correlated with the changes in maternal gut microbiota. Research purpose was to compile the existing bits of present scientific data and to close the gap in the knowledge of changes in gut microbiota in preeclampsia and their association with preeclampsia. We searched studies from two electronic databases (PubMed and Web of Science) included from 2014 to 2023. This review is divided into three parts. In the first part, the author elaborates longitudinal differences of maternal gut microbiota during different gestation periods. In the second part, we discuss that gut microbiota can lead to the occurrence of preeclampsia by systemic immune response, influencing the release of active peptides, short-chain fatty acids, trimethylamine-N-oxide (TMAO) and other metabolites, vascular factors and Microorganism-immune axis. In the third part, we proposed that a high-fiber diet combined with drugs and microecological regulators may be therapeutic in enhancing or preventing the emergence and evolution of preeclampsia, which needs further exploration. Although the pathogenesis of preeclampsia is still nebulous and there is no clear and valid clinical treatment, our study provides new ideas for the pathogenesis, prevention and treatment of preeclampsia. |
| first_indexed | 2024-03-11T14:28:55Z |
| format | Article |
| id | doaj.art-2984a60642fc4d8a8b56c9d4a31912fb |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-11T14:28:55Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-2984a60642fc4d8a8b56c9d4a31912fb2023-10-31T10:29:30ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-10-011310.3389/fcimb.2023.12569401256940Research progress on the correlation between gut microbiota and preeclampsia: microbiome changes, mechanisms and treatmentsYichi Zong0Xuguang Wang1Jun Wang2Department of Obstetrics and Gynecology, Shengjing Affiliated Hospital of China Medical University, Shenyang, Liaoning, ChinaSun Yatsen University Cancer Center, Guangzhou, Guangdong, ChinaDepartment of Obstetrics and Gynecology, Shengjing Affiliated Hospital of China Medical University, Shenyang, Liaoning, ChinaPreeclampsia is a specific disease during pregnancy and is a significant factor in the increased mortality in perinatal women. Gut microbiota, an intricate and abundant microbial community in the digestive tract, is crucial for host metabolism, immunity, and nutrient absorption. The onset and progression of preeclampsia are closely correlated with the changes in maternal gut microbiota. Research purpose was to compile the existing bits of present scientific data and to close the gap in the knowledge of changes in gut microbiota in preeclampsia and their association with preeclampsia. We searched studies from two electronic databases (PubMed and Web of Science) included from 2014 to 2023. This review is divided into three parts. In the first part, the author elaborates longitudinal differences of maternal gut microbiota during different gestation periods. In the second part, we discuss that gut microbiota can lead to the occurrence of preeclampsia by systemic immune response, influencing the release of active peptides, short-chain fatty acids, trimethylamine-N-oxide (TMAO) and other metabolites, vascular factors and Microorganism-immune axis. In the third part, we proposed that a high-fiber diet combined with drugs and microecological regulators may be therapeutic in enhancing or preventing the emergence and evolution of preeclampsia, which needs further exploration. Although the pathogenesis of preeclampsia is still nebulous and there is no clear and valid clinical treatment, our study provides new ideas for the pathogenesis, prevention and treatment of preeclampsia.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1256940/fullgut microbiotapreeclampsiamicrobiome-immune axismicroecological therapyprobiotics |
| spellingShingle | Yichi Zong Xuguang Wang Jun Wang Research progress on the correlation between gut microbiota and preeclampsia: microbiome changes, mechanisms and treatments Frontiers in Cellular and Infection Microbiology gut microbiota preeclampsia microbiome-immune axis microecological therapy probiotics |
| title | Research progress on the correlation between gut microbiota and preeclampsia: microbiome changes, mechanisms and treatments |
| title_full | Research progress on the correlation between gut microbiota and preeclampsia: microbiome changes, mechanisms and treatments |
| title_fullStr | Research progress on the correlation between gut microbiota and preeclampsia: microbiome changes, mechanisms and treatments |
| title_full_unstemmed | Research progress on the correlation between gut microbiota and preeclampsia: microbiome changes, mechanisms and treatments |
| title_short | Research progress on the correlation between gut microbiota and preeclampsia: microbiome changes, mechanisms and treatments |
| title_sort | research progress on the correlation between gut microbiota and preeclampsia microbiome changes mechanisms and treatments |
| topic | gut microbiota preeclampsia microbiome-immune axis microecological therapy probiotics |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1256940/full |
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