Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice
No scientific report proves the action of the phytochemicals from the mangrove tree Rhizophora mangle in the treatment of diabetes. The aim of this work is to evaluate the effects of the acetonic extract of R. mangle barks (AERM) on type 2 diabetes. The main chemical constituents of the extract were...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-08-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/23/9/2114 |
| _version_ | 1811219433557852160 |
|---|---|
| author | Leonardo Mendes de Souza Mesquita Cíntia Rabelo e Paiva Caria Paola Souza Santos Caio Cesar Ruy Natalia da Silva Lima Débora Kono Taketa Moreira Claudia Quintino da Rocha Daniella Carisa Murador Veridiana Vera de Rosso Alessandra Gambero Wagner Vilegas |
| author_facet | Leonardo Mendes de Souza Mesquita Cíntia Rabelo e Paiva Caria Paola Souza Santos Caio Cesar Ruy Natalia da Silva Lima Débora Kono Taketa Moreira Claudia Quintino da Rocha Daniella Carisa Murador Veridiana Vera de Rosso Alessandra Gambero Wagner Vilegas |
| author_sort | Leonardo Mendes de Souza Mesquita |
| collection | DOAJ |
| description | No scientific report proves the action of the phytochemicals from the mangrove tree Rhizophora mangle in the treatment of diabetes. The aim of this work is to evaluate the effects of the acetonic extract of R. mangle barks (AERM) on type 2 diabetes. The main chemical constituents of the extract were analyzed by high-performance liquid chromatography (HPLC) and flow injection analysis electrospray-iontrap mass spectrometry (FIA-ESI-IT-MS/MS). High-fat diet (HFD)-fed mice were used as model of type 2 diabetes associated with obesity. After 4 weeks of AERM 5 or 50 mg/kg/day orally, glucose homeostasis was evaluated by insulin tolerance test (kiTT). Hepatic steatosis, triglycerides and gene expression were also evaluated. AERM consists of catechin, quercetin and chlorogenic acids derivatives. These metabolites have nutritional importance, obese mice treated with AERM (50 mg/kg) presented improvements in insulin resistance resulting in hepatic steatosis reductions associated with a strong inhibition of hepatic mRNA levels of CD36. The beneficial effects of AERM in an obesity model could be associated with its inhibitory α-amylase activity detected in vitro. Rhizophora mangle partially reverses insulin resistance and hepatic steatosis associated with obesity, supporting previous claims in traditional knowledge. |
| first_indexed | 2024-04-12T07:25:40Z |
| format | Article |
| id | doaj.art-2984d4fe5c64446bbe620bfe0d1fe228 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T07:25:40Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2984d4fe5c64446bbe620bfe0d1fe2282022-12-22T03:42:12ZengMDPI AGMolecules1420-30492018-08-01239211410.3390/molecules23092114molecules23092114Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese MiceLeonardo Mendes de Souza Mesquita0Cíntia Rabelo e Paiva Caria1Paola Souza Santos2Caio Cesar Ruy3Natalia da Silva Lima4Débora Kono Taketa Moreira5Claudia Quintino da Rocha6Daniella Carisa Murador7Veridiana Vera de Rosso8Alessandra Gambero9Wagner Vilegas10UNESP—São Paulo State University/Coastal Campus of São Vicente, Laboratory of Bioprospection of Natural Products (LBPN) Pça Infante Dom Henrique S/N, 11330-900 São Vicente, SP, BrazilClinical Pharmacology and Gastroenterology Unit, USF—São Francisco University, Av. São Francisco de Assis, 218, 12916-900 Bragança Paulista, SP, BrazilClinical Pharmacology and Gastroenterology Unit, USF—São Francisco University, Av. São Francisco de Assis, 218, 12916-900 Bragança Paulista, SP, BrazilClinical Pharmacology and Gastroenterology Unit, USF—São Francisco University, Av. São Francisco de Assis, 218, 12916-900 Bragança Paulista, SP, BrazilClinical Pharmacology and Gastroenterology Unit, USF—São Francisco University, Av. São Francisco de Assis, 218, 12916-900 Bragança Paulista, SP, BrazilClinical Pharmacology and Gastroenterology Unit, USF—São Francisco University, Av. São Francisco de Assis, 218, 12916-900 Bragança Paulista, SP, BrazilUNESP—São Paulo State University/Coastal Campus of São Vicente, Laboratory of Bioprospection of Natural Products (LBPN) Pça Infante Dom Henrique S/N, 11330-900 São Vicente, SP, BrazilDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Vila Mathias, 11015-020 Santos City, SP, BrazilDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Vila Mathias, 11015-020 Santos City, SP, BrazilClinical Pharmacology and Gastroenterology Unit, USF—São Francisco University, Av. São Francisco de Assis, 218, 12916-900 Bragança Paulista, SP, BrazilUNESP—São Paulo State University/Coastal Campus of São Vicente, Laboratory of Bioprospection of Natural Products (LBPN) Pça Infante Dom Henrique S/N, 11330-900 São Vicente, SP, BrazilNo scientific report proves the action of the phytochemicals from the mangrove tree Rhizophora mangle in the treatment of diabetes. The aim of this work is to evaluate the effects of the acetonic extract of R. mangle barks (AERM) on type 2 diabetes. The main chemical constituents of the extract were analyzed by high-performance liquid chromatography (HPLC) and flow injection analysis electrospray-iontrap mass spectrometry (FIA-ESI-IT-MS/MS). High-fat diet (HFD)-fed mice were used as model of type 2 diabetes associated with obesity. After 4 weeks of AERM 5 or 50 mg/kg/day orally, glucose homeostasis was evaluated by insulin tolerance test (kiTT). Hepatic steatosis, triglycerides and gene expression were also evaluated. AERM consists of catechin, quercetin and chlorogenic acids derivatives. These metabolites have nutritional importance, obese mice treated with AERM (50 mg/kg) presented improvements in insulin resistance resulting in hepatic steatosis reductions associated with a strong inhibition of hepatic mRNA levels of CD36. The beneficial effects of AERM in an obesity model could be associated with its inhibitory α-amylase activity detected in vitro. Rhizophora mangle partially reverses insulin resistance and hepatic steatosis associated with obesity, supporting previous claims in traditional knowledge.http://www.mdpi.com/1420-3049/23/9/2114polyphenolstype 2 diabetesnon-alcoholic fatty liver diseaseCD36catechins |
| spellingShingle | Leonardo Mendes de Souza Mesquita Cíntia Rabelo e Paiva Caria Paola Souza Santos Caio Cesar Ruy Natalia da Silva Lima Débora Kono Taketa Moreira Claudia Quintino da Rocha Daniella Carisa Murador Veridiana Vera de Rosso Alessandra Gambero Wagner Vilegas Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice Molecules polyphenols type 2 diabetes non-alcoholic fatty liver disease CD36 catechins |
| title | Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice |
| title_full | Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice |
| title_fullStr | Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice |
| title_full_unstemmed | Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice |
| title_short | Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice |
| title_sort | modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l on non alcoholic fatty liver disease and insulin resistance in high fat diet obese mice |
| topic | polyphenols type 2 diabetes non-alcoholic fatty liver disease CD36 catechins |
| url | http://www.mdpi.com/1420-3049/23/9/2114 |
| work_keys_str_mv | AT leonardomendesdesouzamesquita modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice AT cintiarabeloepaivacaria modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice AT paolasouzasantos modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice AT caiocesarruy modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice AT nataliadasilvalima modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice AT deborakonotaketamoreira modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice AT claudiaquintinodarocha modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice AT daniellacarisamurador modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice AT veridianaveraderosso modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice AT alessandragambero modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice AT wagnervilegas modulatoryeffectofpolyphenoliccompoundsfromthemangrovetreerhizophoramanglelonnonalcoholicfattyliverdiseaseandinsulinresistanceinhighfatdietobesemice |