A study on the demographic, clinical, and radiological profile of lineage B.1.1.7 (United Kingdom) strain Covid-19 patients at Telangana institute of medical sciences and research, Hyderabad
Background: Emergence of variants with specific mutations in key epitopes in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raises concerns pertinent to its severity. Aims and Objectives: To assess the demographics, clinico-radiological pattern, and outcome of r...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-01-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/40630 |
| _version_ | 1819097170694897664 |
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| author | Jayasri Helen Gali Manasa Musku Devireddy Pallavi Reddy Vimala Thomas Ehsan Ahmed Khan |
| author_facet | Jayasri Helen Gali Manasa Musku Devireddy Pallavi Reddy Vimala Thomas Ehsan Ahmed Khan |
| author_sort | Jayasri Helen Gali |
| collection | DOAJ |
| description | Background: Emergence of variants with specific mutations in key epitopes in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raises concerns pertinent to its severity.
Aims and Objectives: To assess the demographics, clinico-radiological pattern, and outcome of reverse transcription-polymerase chain reaction (RT-PCR) positive isolated coronavirus disease 2019 (COVID-19) patients arrived from the United Kingdom (UK).
Materials and Methods: A cross-sectional, observational study was conducted in RT-PCR positive COVID-19 patients arrived from the UK, from December 2020 to February 2021. Nasopharyngeal samples of all patients were sent for whole-genome sequencing of SARS-CoV-2. The aimed parameters were compared between the B.1.17 positive and non-B.1.1.7 groups, among the people, arrived from the UK. All statistical tests with P<0.05 were considered significant.
Results: A total of 59 SARS-CoV2 infected patients, who arrived from the UK, were isolated from December 2020 to February 2021 at Telangana Institute of Medical Sciences hospital, Hyderabad, were enrolled in the study. Of these, 27 patients (mean age-31.81±11.28 years) were infected with the B.1.1.7, diagnosed by whole genomic sequencing. Males were predominant in our study. Personal habits such as smoking, alcohol intake were higher among the sequenced group with a significant P<0.05. The most common symptoms observed in the sequenced group were cough (22.22%), sore throat (22.22%), cold (11.11%), fever (11.11%), and in the unsequenced group were cough (22.22%), cold (6.25%), fever (6.25%). In the sequenced group, chest X-ray posteroanterior view was normal in 74%, patchy ground-glass opacities was observed in 25.92% patients, whereas in the unsequenced group it was 84.37% and 15.62%, respectively. Asymptomatic patients, observed in the sequenced and unsequenced group were 48.18% and 78.12%, respectively, and symptomatic patients were 51.85% and 21.87%, respectively. We found a statistically significant difference between sequenced and unsequenced patients in the asymptomatic group with a significant P<0.05. In the sequenced and unsequenced group, mild cases were 48.18% and 18.75%, moderate cases were 3.7% and 3.12%, respectively. We found no evidence of an association between disease severity and lineage B.1.17.
Conclusion: Our data, within the context and limitations of a real-world study, provide initial reassurance that severity in hospitalized patients with B.1.1.7 is not markedly different from severity in those without B.1.1.7. |
| first_indexed | 2024-12-22T00:10:50Z |
| format | Article |
| id | doaj.art-29850b6ceb6f40a78670e5214856ae86 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-22T00:10:50Z |
| publishDate | 2022-01-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-29850b6ceb6f40a78670e5214856ae862022-12-21T18:45:27ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-01-011311318https://doi.org/10.3126/ajms.v13i1.40630A study on the demographic, clinical, and radiological profile of lineage B.1.1.7 (United Kingdom) strain Covid-19 patients at Telangana institute of medical sciences and research, HyderabadJayasri Helen Gali 0https://orcid.org/0000-0002-2623-2825Manasa Musku 1https://orcid.org/0000-0002-3681-5186Devireddy Pallavi Reddy 2https://orcid.org/0000-0002-2281-6209Vimala Thomas 3https://orcid.org/0000-0003-2521-8375Ehsan Ahmed Khan 4https://orcid.org/0000-0001-9435-4675Professor and Head of Department, Department of Pulmonary Medicine, Telangana Institute of Medical Sciences and Research, Hyderabad, Telangana, India Assistant Professor, Department of Pulmonary Medicine, Telangana Institute of Medical Sciences and Research, Hyderabad, Telangana, India Assistant Professor, Department of Pulmonary Medicine, Telangana Institute of Medical Sciences and Research, Hyderabad, Telangana, India Professor, Department of Social and Preventive Medicine and Director, Telangana Institute of Medical Sciences and Research, Hyderabad, Telangana, India Assistant Professor, Department of General Medicine and Medical Superintendent, Telangana Institute of Medical Sciences and Research, Hyderabad, Telangana, India Background: Emergence of variants with specific mutations in key epitopes in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raises concerns pertinent to its severity. Aims and Objectives: To assess the demographics, clinico-radiological pattern, and outcome of reverse transcription-polymerase chain reaction (RT-PCR) positive isolated coronavirus disease 2019 (COVID-19) patients arrived from the United Kingdom (UK). Materials and Methods: A cross-sectional, observational study was conducted in RT-PCR positive COVID-19 patients arrived from the UK, from December 2020 to February 2021. Nasopharyngeal samples of all patients were sent for whole-genome sequencing of SARS-CoV-2. The aimed parameters were compared between the B.1.17 positive and non-B.1.1.7 groups, among the people, arrived from the UK. All statistical tests with P<0.05 were considered significant. Results: A total of 59 SARS-CoV2 infected patients, who arrived from the UK, were isolated from December 2020 to February 2021 at Telangana Institute of Medical Sciences hospital, Hyderabad, were enrolled in the study. Of these, 27 patients (mean age-31.81±11.28 years) were infected with the B.1.1.7, diagnosed by whole genomic sequencing. Males were predominant in our study. Personal habits such as smoking, alcohol intake were higher among the sequenced group with a significant P<0.05. The most common symptoms observed in the sequenced group were cough (22.22%), sore throat (22.22%), cold (11.11%), fever (11.11%), and in the unsequenced group were cough (22.22%), cold (6.25%), fever (6.25%). In the sequenced group, chest X-ray posteroanterior view was normal in 74%, patchy ground-glass opacities was observed in 25.92% patients, whereas in the unsequenced group it was 84.37% and 15.62%, respectively. Asymptomatic patients, observed in the sequenced and unsequenced group were 48.18% and 78.12%, respectively, and symptomatic patients were 51.85% and 21.87%, respectively. We found a statistically significant difference between sequenced and unsequenced patients in the asymptomatic group with a significant P<0.05. In the sequenced and unsequenced group, mild cases were 48.18% and 18.75%, moderate cases were 3.7% and 3.12%, respectively. We found no evidence of an association between disease severity and lineage B.1.17. Conclusion: Our data, within the context and limitations of a real-world study, provide initial reassurance that severity in hospitalized patients with B.1.1.7 is not markedly different from severity in those without B.1.1.7.https://www.nepjol.info/index.php/AJMS/article/view/40630coronavirus disease 2019genomic sequencingmutationreverse transcription polymerase chain reactionsevere acute respiratory syndrome coronavirus 2 b.1.1.7symptom |
| spellingShingle | Jayasri Helen Gali Manasa Musku Devireddy Pallavi Reddy Vimala Thomas Ehsan Ahmed Khan A study on the demographic, clinical, and radiological profile of lineage B.1.1.7 (United Kingdom) strain Covid-19 patients at Telangana institute of medical sciences and research, Hyderabad Asian Journal of Medical Sciences coronavirus disease 2019 genomic sequencing mutation reverse transcription polymerase chain reaction severe acute respiratory syndrome coronavirus 2 b.1.1.7 symptom |
| title | A study on the demographic, clinical, and radiological profile of lineage B.1.1.7 (United Kingdom) strain Covid-19 patients at Telangana institute of medical sciences and research, Hyderabad |
| title_full | A study on the demographic, clinical, and radiological profile of lineage B.1.1.7 (United Kingdom) strain Covid-19 patients at Telangana institute of medical sciences and research, Hyderabad |
| title_fullStr | A study on the demographic, clinical, and radiological profile of lineage B.1.1.7 (United Kingdom) strain Covid-19 patients at Telangana institute of medical sciences and research, Hyderabad |
| title_full_unstemmed | A study on the demographic, clinical, and radiological profile of lineage B.1.1.7 (United Kingdom) strain Covid-19 patients at Telangana institute of medical sciences and research, Hyderabad |
| title_short | A study on the demographic, clinical, and radiological profile of lineage B.1.1.7 (United Kingdom) strain Covid-19 patients at Telangana institute of medical sciences and research, Hyderabad |
| title_sort | study on the demographic clinical and radiological profile of lineage b 1 1 7 united kingdom strain covid 19 patients at telangana institute of medical sciences and research hyderabad |
| topic | coronavirus disease 2019 genomic sequencing mutation reverse transcription polymerase chain reaction severe acute respiratory syndrome coronavirus 2 b.1.1.7 symptom |
| url | https://www.nepjol.info/index.php/AJMS/article/view/40630 |
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