Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane

Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane

The SNAREs SNAP25 and SNAP23 are proteins that are initially cytosolic after translation, but then become stably attached to the cell membrane through palmitoylation of cysteine residues. For palmitoylation to occur, membrane association is a prerequisite, but it is unclear which motif may increase...

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Bibliographic Details
Main Authors: Pascal Weber, Helena Batoulis, Kerstin M Rink, Stefan Dahlhoff, Kerstin Pinkwart, Thomas H Söllner, Thorsten Lang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-02-01
Series:eLife
Subjects:
protein electrostatics
membrane targeting
phosphoinositides
SNAREs
liposome
post-translational modification
Online Access:https://elifesciences.org/articles/19394

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