The Relationship Between Premature Adrenarche and Platelet Aggregation
INTRODUCTION: Premature adrenarche (PA) has been associated with an increase in adrenal androgens, and the hyperandrogenic hormonal environment is known to lead to increased platelet (PLT) aggregation. Here, we evaluated the effects of PA on PLT aggregation in PLT-rich plasma samples from female pat...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2023-03-01
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| Series: | JCRPE |
| Subjects: | |
| Online Access: | https://jcrpe.org/jvi.aspx?un=JCRPE-60252&volume=15&issue=1 |
| _version_ | 1811161475726704640 |
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| author | Ahmet Bolat Cengiz Zeybek Orhan Gürsel Onur Akın Mehmet Emre Taşçılar |
| author_facet | Ahmet Bolat Cengiz Zeybek Orhan Gürsel Onur Akın Mehmet Emre Taşçılar |
| author_sort | Ahmet Bolat |
| collection | DOAJ |
| description | INTRODUCTION: Premature adrenarche (PA) has been associated with an increase in adrenal androgens, and the hyperandrogenic hormonal environment is known to lead to increased platelet (PLT) aggregation. Here, we evaluated the effects of PA on PLT aggregation in PLT-rich plasma samples from female patients.
METHODS: The study included 40 female patients diagnosed with PA between February, 2014 and June, 2018 and 30 healthy female individuals as a control group. Adenosine diphosphate (ADP) and collagen-induced PLT aggregation were studied via the photometric aggregometry method.
RESULTS: There were no significant differences in the PLT count or volume values between those participants with PA and the control group. Additionally, the ADP-induced maximum aggregation time, value, and slope values did not significantly differ between the patient and control groups (p>0.05). However, the collagen-induced maximum aggregation time, value, and slope values were significantly higher in the studygroup (p<0.001).
DISCUSSION AND CONCLUSION: Increased collagen-induced PLT aggregation was detected in female patients with PA. As PA is associated with a higher risk of cardiovascular events later in life, close follow-up of PA in this respect may be beneficial. |
| first_indexed | 2024-04-10T06:14:47Z |
| format | Article |
| id | doaj.art-2985dee2a4ae4b09a546d94b76212163 |
| institution | Directory Open Access Journal |
| issn | 1308-5727 1308-5735 |
| language | English |
| last_indexed | 2024-04-10T06:14:47Z |
| publishDate | 2023-03-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | JCRPE |
| spelling | doaj.art-2985dee2a4ae4b09a546d94b762121632023-03-02T08:46:14ZengGalenos YayincilikJCRPE1308-57271308-57352023-03-01151556110.4274/jcrpe.galenos.2022.2022-6-13The Relationship Between Premature Adrenarche and Platelet AggregationAhmet Bolat0https://orcid.org/0000-0001-6653-0045Cengiz Zeybek1https://orcid.org/0000-0002-4820-0373Orhan Gürsel2https://orcid.org/0000-0002-2077-8093Onur Akın3https://orcid.org/0000-0002-8430-5519Mehmet Emre Taşçılar4https://orcid.org/0000-0001-7809-6987University of Health Sciences Turkey, Gülhane Faculty of Medicine, Department of Child Health and Diseases, Ankara, TurkeyUniversity of Health Sciences Turkey, Gülhane Faculty of Medicine, Department of Child Health and Diseases, Ankara, TurkeyUniversity of Health Sciences Turkey, Gülhane Faculty of Medicine, Department of Pediatric Hematology, Ankara, TurkeyUniversity of Health Sciences Turkey, Gülhane Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, TurkeyYüksek İhtisas University, Koru Hospital, Clinic of Pediatric Endocrinology, Ankara, TurkeyINTRODUCTION: Premature adrenarche (PA) has been associated with an increase in adrenal androgens, and the hyperandrogenic hormonal environment is known to lead to increased platelet (PLT) aggregation. Here, we evaluated the effects of PA on PLT aggregation in PLT-rich plasma samples from female patients. METHODS: The study included 40 female patients diagnosed with PA between February, 2014 and June, 2018 and 30 healthy female individuals as a control group. Adenosine diphosphate (ADP) and collagen-induced PLT aggregation were studied via the photometric aggregometry method. RESULTS: There were no significant differences in the PLT count or volume values between those participants with PA and the control group. Additionally, the ADP-induced maximum aggregation time, value, and slope values did not significantly differ between the patient and control groups (p>0.05). However, the collagen-induced maximum aggregation time, value, and slope values were significantly higher in the studygroup (p<0.001). DISCUSSION AND CONCLUSION: Increased collagen-induced PLT aggregation was detected in female patients with PA. As PA is associated with a higher risk of cardiovascular events later in life, close follow-up of PA in this respect may be beneficial.https://jcrpe.org/jvi.aspx?un=JCRPE-60252&volume=15&issue=1premature adrenarchecardiovascular diseaseshyperandrogenismplatelet aggregationadpcollagen |
| spellingShingle | Ahmet Bolat Cengiz Zeybek Orhan Gürsel Onur Akın Mehmet Emre Taşçılar The Relationship Between Premature Adrenarche and Platelet Aggregation JCRPE premature adrenarche cardiovascular diseases hyperandrogenism platelet aggregation adp collagen |
| title | The Relationship Between Premature Adrenarche and Platelet Aggregation |
| title_full | The Relationship Between Premature Adrenarche and Platelet Aggregation |
| title_fullStr | The Relationship Between Premature Adrenarche and Platelet Aggregation |
| title_full_unstemmed | The Relationship Between Premature Adrenarche and Platelet Aggregation |
| title_short | The Relationship Between Premature Adrenarche and Platelet Aggregation |
| title_sort | relationship between premature adrenarche and platelet aggregation |
| topic | premature adrenarche cardiovascular diseases hyperandrogenism platelet aggregation adp collagen |
| url | https://jcrpe.org/jvi.aspx?un=JCRPE-60252&volume=15&issue=1 |
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