Effects of the Ethanol Extract of <i>Dipterocarpus alatus</i> Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action
Treatment of the unpredictable chronic mild stress (UCMS) mice with the ethanol extract of <i>Dipterocarpus alatus</i> leaf attenuated anhedonia (increased sucrose preference) and behavioral despair (decreased immobility time in tail suspension test (TST) and forced swimming test (FST))....
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-09-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/18/3396 |
| _version_ | 1818117108399079424 |
|---|---|
| author | Supawadee Daodee Orawan Monthakantirat Kanlaya Ruengwinitwong Kankrittanon Gatenakorn Juthamart Maneenet Charinya Khamphukdee Nazim Sekeroglu Yaowared Chulikhit Anake Kijjoa |
| author_facet | Supawadee Daodee Orawan Monthakantirat Kanlaya Ruengwinitwong Kankrittanon Gatenakorn Juthamart Maneenet Charinya Khamphukdee Nazim Sekeroglu Yaowared Chulikhit Anake Kijjoa |
| author_sort | Supawadee Daodee |
| collection | DOAJ |
| description | Treatment of the unpredictable chronic mild stress (UCMS) mice with the ethanol extract of <i>Dipterocarpus alatus</i> leaf attenuated anhedonia (increased sucrose preference) and behavioral despair (decreased immobility time in tail suspension test (TST) and forced swimming test (FST)). The extract not only decreased the elevation of serum corticosterone level and the index of over-activation of the hypothalamic-pituitary-adrenal (HPA) axis, caused by UCMS, but also ameliorated UCMS-induced up-regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) mRNA expression and down-regulation of cyclic AMP-responsive element binding (CREB) and brain-derived neurotrophic factor (BDNF) mRNAs in frontal cortex and hippocampus. In vitro monoamine oxidase (MAO) inhibition assays showed that the extract exhibited the partial selective inhibition on MAO-A. HPLC analysis of the extract showed the presence of flavonoids (luteolin-7-<i>O</i>-glucoside, kaempferol-3-glucoside, rutin) and phenolic acids (gallic acid, ferulic acid, and caffeic acid) as major constituents. |
| first_indexed | 2024-12-11T04:33:10Z |
| format | Article |
| id | doaj.art-29865f06e00041ac82da82b11e185ff0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T04:33:10Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-29865f06e00041ac82da82b11e185ff02022-12-22T01:20:48ZengMDPI AGMolecules1420-30492019-09-012418339610.3390/molecules24183396molecules24183396Effects of the Ethanol Extract of <i>Dipterocarpus alatus</i> Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of ActionSupawadee Daodee0Orawan Monthakantirat1Kanlaya Ruengwinitwong2Kankrittanon Gatenakorn3Juthamart Maneenet4Charinya Khamphukdee5Nazim Sekeroglu6Yaowared Chulikhit7Anake Kijjoa8Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Horticulture, Faculty of Agriculture, Killis 7 Aralik University, Killis 79000, TurkeyDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandICBAS-Instituto de Ciências Biomédicas Abel Salazar and CIIMAR, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, PortugalTreatment of the unpredictable chronic mild stress (UCMS) mice with the ethanol extract of <i>Dipterocarpus alatus</i> leaf attenuated anhedonia (increased sucrose preference) and behavioral despair (decreased immobility time in tail suspension test (TST) and forced swimming test (FST)). The extract not only decreased the elevation of serum corticosterone level and the index of over-activation of the hypothalamic-pituitary-adrenal (HPA) axis, caused by UCMS, but also ameliorated UCMS-induced up-regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) mRNA expression and down-regulation of cyclic AMP-responsive element binding (CREB) and brain-derived neurotrophic factor (BDNF) mRNAs in frontal cortex and hippocampus. In vitro monoamine oxidase (MAO) inhibition assays showed that the extract exhibited the partial selective inhibition on MAO-A. HPLC analysis of the extract showed the presence of flavonoids (luteolin-7-<i>O</i>-glucoside, kaempferol-3-glucoside, rutin) and phenolic acids (gallic acid, ferulic acid, and caffeic acid) as major constituents.https://www.mdpi.com/1420-3049/24/18/3396<i>Dipterocarpus alatus</i>flavonoidsdepressionUCMSHPA axisneurogenesisMAO-A inhibition |
| spellingShingle | Supawadee Daodee Orawan Monthakantirat Kanlaya Ruengwinitwong Kankrittanon Gatenakorn Juthamart Maneenet Charinya Khamphukdee Nazim Sekeroglu Yaowared Chulikhit Anake Kijjoa Effects of the Ethanol Extract of <i>Dipterocarpus alatus</i> Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action Molecules <i>Dipterocarpus alatus</i> flavonoids depression UCMS HPA axis neurogenesis MAO-A inhibition |
| title | Effects of the Ethanol Extract of <i>Dipterocarpus alatus</i> Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action |
| title_full | Effects of the Ethanol Extract of <i>Dipterocarpus alatus</i> Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action |
| title_fullStr | Effects of the Ethanol Extract of <i>Dipterocarpus alatus</i> Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action |
| title_full_unstemmed | Effects of the Ethanol Extract of <i>Dipterocarpus alatus</i> Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action |
| title_short | Effects of the Ethanol Extract of <i>Dipterocarpus alatus</i> Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action |
| title_sort | effects of the ethanol extract of i dipterocarpus alatus i leaf on the unpredictable chronic mild stress induced depression in icr mice and its possible mechanism of action |
| topic | <i>Dipterocarpus alatus</i> flavonoids depression UCMS HPA axis neurogenesis MAO-A inhibition |
| url | https://www.mdpi.com/1420-3049/24/18/3396 |
| work_keys_str_mv | AT supawadeedaodee effectsoftheethanolextractofidipterocarpusalatusileafontheunpredictablechronicmildstressinduceddepressioninicrmiceanditspossiblemechanismofaction AT orawanmonthakantirat effectsoftheethanolextractofidipterocarpusalatusileafontheunpredictablechronicmildstressinduceddepressioninicrmiceanditspossiblemechanismofaction AT kanlayaruengwinitwong effectsoftheethanolextractofidipterocarpusalatusileafontheunpredictablechronicmildstressinduceddepressioninicrmiceanditspossiblemechanismofaction AT kankrittanongatenakorn effectsoftheethanolextractofidipterocarpusalatusileafontheunpredictablechronicmildstressinduceddepressioninicrmiceanditspossiblemechanismofaction AT juthamartmaneenet effectsoftheethanolextractofidipterocarpusalatusileafontheunpredictablechronicmildstressinduceddepressioninicrmiceanditspossiblemechanismofaction AT charinyakhamphukdee effectsoftheethanolextractofidipterocarpusalatusileafontheunpredictablechronicmildstressinduceddepressioninicrmiceanditspossiblemechanismofaction AT nazimsekeroglu effectsoftheethanolextractofidipterocarpusalatusileafontheunpredictablechronicmildstressinduceddepressioninicrmiceanditspossiblemechanismofaction AT yaowaredchulikhit effectsoftheethanolextractofidipterocarpusalatusileafontheunpredictablechronicmildstressinduceddepressioninicrmiceanditspossiblemechanismofaction AT anakekijjoa effectsoftheethanolextractofidipterocarpusalatusileafontheunpredictablechronicmildstressinduceddepressioninicrmiceanditspossiblemechanismofaction |