Genome-Wide Characterization and Analysis of Expression of the Histone Gene Family in Razor Clam, <i>Sinonovacula constricta</i>
The Chinese razor clam (<i>Sinonovacula constricta</i>), a bivalve species widely distributed in estuaries and mudflats, is often exposed to extreme environmental and microbial stresses. Histones are fundamental components of chromatin and play an important role in innate immunity, as de...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Fishes |
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| Online Access: | https://www.mdpi.com/2410-3888/7/1/5 |
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| author | Jiaying Lian Liyuan Lv Hanhan Yao Zhihua Lin Yinghui Dong |
| author_facet | Jiaying Lian Liyuan Lv Hanhan Yao Zhihua Lin Yinghui Dong |
| author_sort | Jiaying Lian |
| collection | DOAJ |
| description | The Chinese razor clam (<i>Sinonovacula constricta</i>), a bivalve species widely distributed in estuaries and mudflats, is often exposed to extreme environmental and microbial stresses. Histones are fundamental components of chromatin and play an important role in innate immunity, as demonstrated by its antimicrobial activities in clams. However, little attention has been paid to histones in bivalves. To fill this gap, we investigated the genomic distribution, structural characteristics, conserved motifs, and phylogenetic relationships of histones in <i>S. constricta</i>. A total of 114 histone genes were detected in the <i>S. constricta</i> genome, which were divided into 25 types in phylogenetic analysis. Among them, partial histones exhibited a tissue-dependent expression pattern, indicating that they may be involved in sustaining the homeostasis of organs/tissues in adult <i>S. constricta</i>. Furthermore, mRNA expression of certain histones changed significantly in <i>S. constricta</i> when infected with <i>Vibrio parahaemolyticus</i>, suggesting that histones play a role in the immune defense of <i>S. constricta</i>. All together, this study on histone genes in <i>S. constricta</i> not only greatly expands our knowledge of histone function in the clam, but also histone evolution in molluscs. |
| first_indexed | 2024-03-09T21:59:22Z |
| format | Article |
| id | doaj.art-29877f6b3c6e47e9b81f86a4539f150a |
| institution | Directory Open Access Journal |
| issn | 2410-3888 |
| language | English |
| last_indexed | 2024-03-09T21:59:22Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fishes |
| spelling | doaj.art-29877f6b3c6e47e9b81f86a4539f150a2023-11-23T19:51:15ZengMDPI AGFishes2410-38882021-12-0171510.3390/fishes7010005Genome-Wide Characterization and Analysis of Expression of the Histone Gene Family in Razor Clam, <i>Sinonovacula constricta</i>Jiaying Lian0Liyuan Lv1Hanhan Yao2Zhihua Lin3Yinghui Dong4Zhejiang Key Laboratory of Aquatic Germplasm Resources, College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, ChinaZhejiang Key Laboratory of Aquatic Germplasm Resources, College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, ChinaZhejiang Key Laboratory of Aquatic Germplasm Resources, College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, ChinaZhejiang Key Laboratory of Aquatic Germplasm Resources, College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, ChinaZhejiang Key Laboratory of Aquatic Germplasm Resources, College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, ChinaThe Chinese razor clam (<i>Sinonovacula constricta</i>), a bivalve species widely distributed in estuaries and mudflats, is often exposed to extreme environmental and microbial stresses. Histones are fundamental components of chromatin and play an important role in innate immunity, as demonstrated by its antimicrobial activities in clams. However, little attention has been paid to histones in bivalves. To fill this gap, we investigated the genomic distribution, structural characteristics, conserved motifs, and phylogenetic relationships of histones in <i>S. constricta</i>. A total of 114 histone genes were detected in the <i>S. constricta</i> genome, which were divided into 25 types in phylogenetic analysis. Among them, partial histones exhibited a tissue-dependent expression pattern, indicating that they may be involved in sustaining the homeostasis of organs/tissues in adult <i>S. constricta</i>. Furthermore, mRNA expression of certain histones changed significantly in <i>S. constricta</i> when infected with <i>Vibrio parahaemolyticus</i>, suggesting that histones play a role in the immune defense of <i>S. constricta</i>. All together, this study on histone genes in <i>S. constricta</i> not only greatly expands our knowledge of histone function in the clam, but also histone evolution in molluscs.https://www.mdpi.com/2410-3888/7/1/5<i>Sinonovacula constricta</i>histone gene familygenomic organizationexpression profiling<i>Vibrio parahaemolyticus</i> stress |
| spellingShingle | Jiaying Lian Liyuan Lv Hanhan Yao Zhihua Lin Yinghui Dong Genome-Wide Characterization and Analysis of Expression of the Histone Gene Family in Razor Clam, <i>Sinonovacula constricta</i> Fishes <i>Sinonovacula constricta</i> histone gene family genomic organization expression profiling <i>Vibrio parahaemolyticus</i> stress |
| title | Genome-Wide Characterization and Analysis of Expression of the Histone Gene Family in Razor Clam, <i>Sinonovacula constricta</i> |
| title_full | Genome-Wide Characterization and Analysis of Expression of the Histone Gene Family in Razor Clam, <i>Sinonovacula constricta</i> |
| title_fullStr | Genome-Wide Characterization and Analysis of Expression of the Histone Gene Family in Razor Clam, <i>Sinonovacula constricta</i> |
| title_full_unstemmed | Genome-Wide Characterization and Analysis of Expression of the Histone Gene Family in Razor Clam, <i>Sinonovacula constricta</i> |
| title_short | Genome-Wide Characterization and Analysis of Expression of the Histone Gene Family in Razor Clam, <i>Sinonovacula constricta</i> |
| title_sort | genome wide characterization and analysis of expression of the histone gene family in razor clam i sinonovacula constricta i |
| topic | <i>Sinonovacula constricta</i> histone gene family genomic organization expression profiling <i>Vibrio parahaemolyticus</i> stress |
| url | https://www.mdpi.com/2410-3888/7/1/5 |
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