Pyrrole–Aminopyrimidine Ensembles: Cycloaddition of Guanidine to Acylethynylpyrroles

Pyrrole–Aminopyrimidine Ensembles: Cycloaddition of Guanidine to Acylethynylpyrroles

An efficient method for the synthesis of pharmaceutically prospective pyrrole–aminopyrimidine ensembles (in up to 91% yield) by the cyclocondensation of easily available acylethynylpyrroles with guanidine nitrate has been developed. The reaction proceeds under heating (110–115 °C, 4 h) in the KOH/DM...

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Bibliographic Details
Main Authors: Olga V. Petrova, Arsalan B. Budaev, Elena F. Sagitova, Igor A. Ushakov, Lyubov N. Sobenina, Andrey V. Ivanov, Boris A. Trofimov
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
acylethynylpyrroles
guanidine
cyclocondensation
aminopyrimidine
Online Access:https://www.mdpi.com/1420-3049/26/6/1692

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