Vibrational Microspectroscopy for Cancer Screening
Vibrational spectroscopy analyses vibrations within a molecule and can be used to characterise a molecular structure. Raman spectroscopy is one of the vibrational spectroscopic techniques, in which incident radiation is used to induce vibrations in the molecules of a sample, and the scattered radia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-02-01
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| Series: | Applied Sciences |
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| Online Access: | http://www.mdpi.com/2076-3417/5/1/23 |
| _version_ | 1819209827736354816 |
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| author | Fiona M. Lyng Inês R. M. Ramos Ola Ibrahim Hugh J. Byrne |
| author_facet | Fiona M. Lyng Inês R. M. Ramos Ola Ibrahim Hugh J. Byrne |
| author_sort | Fiona M. Lyng |
| collection | DOAJ |
| description | Vibrational spectroscopy analyses vibrations within a molecule and can be used to characterise a molecular structure. Raman spectroscopy is one of the vibrational spectroscopic techniques, in which incident radiation is used to induce vibrations in the molecules of a sample, and the scattered radiation may be used to characterise the sample in a rapid and non-destructive manner. Infrared (IR) spectroscopy is a complementary vibrational spectroscopic technique based on the absorption of IR radiation by the sample. Molecules absorb specific frequencies of the incident light which are characteristic of their structure. IR and Raman spectroscopy are sensitive to subtle biochemical changes occurring at the molecular level allowing spectral variations corresponding to disease onset to be detected. Over the past 15 years, there have been numerous reports demonstrating the potential of IR and Raman spectroscopy together with multivariate statistical analysis techniques for the detection of a variety of cancers including, breast, lung, brain, colon, oral, oesophageal, prostate and cervical cancer. This paper discusses the recent advances and the future perspectives in relation to cancer screening applications, focussing on cervical and oral cancer. |
| first_indexed | 2024-12-23T06:01:28Z |
| format | Article |
| id | doaj.art-2989750eaae94e2f88a2b8285b4a41f4 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-12-23T06:01:28Z |
| publishDate | 2015-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-2989750eaae94e2f88a2b8285b4a41f42022-12-21T17:57:39ZengMDPI AGApplied Sciences2076-34172015-02-0151233510.3390/app5010023app5010023Vibrational Microspectroscopy for Cancer ScreeningFiona M. Lyng0Inês R. M. Ramos1Ola Ibrahim2Hugh J. Byrne3DIT Centre for Radiation and Environmental Science, FOCAS Research Institute, Dublin Institute of Technology, Kevin St, Dublin 8, IrelandDIT Centre for Radiation and Environmental Science, FOCAS Research Institute, Dublin Institute of Technology, Kevin St, Dublin 8, IrelandDIT Centre for Radiation and Environmental Science, FOCAS Research Institute, Dublin Institute of Technology, Kevin St, Dublin 8, IrelandFOCAS Research Institute, Dublin Institute of Technology, Kevin St, Dublin 8, IrelandVibrational spectroscopy analyses vibrations within a molecule and can be used to characterise a molecular structure. Raman spectroscopy is one of the vibrational spectroscopic techniques, in which incident radiation is used to induce vibrations in the molecules of a sample, and the scattered radiation may be used to characterise the sample in a rapid and non-destructive manner. Infrared (IR) spectroscopy is a complementary vibrational spectroscopic technique based on the absorption of IR radiation by the sample. Molecules absorb specific frequencies of the incident light which are characteristic of their structure. IR and Raman spectroscopy are sensitive to subtle biochemical changes occurring at the molecular level allowing spectral variations corresponding to disease onset to be detected. Over the past 15 years, there have been numerous reports demonstrating the potential of IR and Raman spectroscopy together with multivariate statistical analysis techniques for the detection of a variety of cancers including, breast, lung, brain, colon, oral, oesophageal, prostate and cervical cancer. This paper discusses the recent advances and the future perspectives in relation to cancer screening applications, focussing on cervical and oral cancer.http://www.mdpi.com/2076-3417/5/1/23optical diagnosislasersRaman spectroscopyFTIR spectroscopycervical canceroral cancerscreeningcytology |
| spellingShingle | Fiona M. Lyng Inês R. M. Ramos Ola Ibrahim Hugh J. Byrne Vibrational Microspectroscopy for Cancer Screening Applied Sciences optical diagnosis lasers Raman spectroscopy FTIR spectroscopy cervical cancer oral cancer screening cytology |
| title | Vibrational Microspectroscopy for Cancer Screening |
| title_full | Vibrational Microspectroscopy for Cancer Screening |
| title_fullStr | Vibrational Microspectroscopy for Cancer Screening |
| title_full_unstemmed | Vibrational Microspectroscopy for Cancer Screening |
| title_short | Vibrational Microspectroscopy for Cancer Screening |
| title_sort | vibrational microspectroscopy for cancer screening |
| topic | optical diagnosis lasers Raman spectroscopy FTIR spectroscopy cervical cancer oral cancer screening cytology |
| url | http://www.mdpi.com/2076-3417/5/1/23 |
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