The Preterm Lung and Airway: Past, Present, and Future
The tremendous advancement that has occurred in neonatal intensive care over the last 40–50 years can be largely attributed to greater understanding of developmental pathobiology in the newborn lung. Nonetheless, this improved survival from respiratory distress syndrome has been associated with cont...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-08-01
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| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957213000363 |
| _version_ | 1828388505035735040 |
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| author | Richard J. Martin Avroy A. Fanaroff |
| author_facet | Richard J. Martin Avroy A. Fanaroff |
| author_sort | Richard J. Martin |
| collection | DOAJ |
| description | The tremendous advancement that has occurred in neonatal intensive care over the last 40–50 years can be largely attributed to greater understanding of developmental pathobiology in the newborn lung. Nonetheless, this improved survival from respiratory distress syndrome has been associated with continuing longer-term morbidity in the form of bronchopulmonary dysplasia (BPD). As a result, neonatal lung injury is a renewed focus of scientific interest. The onset of such an injury may begin in the delivery room, and this has generated interest in minimizing oxygen therapy and aggressive ventilatory support during the transition from fetal to neonatal lung. Fortunately, antenatal steroid therapy and selective use of surfactant therapy are now widely practiced, although fine tuning of this therapy for selected populations is ongoing. Newer therapeutic approaches address many aspects of BPD, including the pro-inflammatory component that characterizes this disorder. Finally, there is a greater need to understand the epidemiology and pathogenesis of the longer-term respiratory morbidity, most notably asthma, that persists in the preterm survivors of neonatal intensive care. |
| first_indexed | 2024-12-10T06:14:34Z |
| format | Article |
| id | doaj.art-298fd15c08674536ae1262a98480354e |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-10T06:14:34Z |
| publishDate | 2013-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-298fd15c08674536ae1262a98480354e2022-12-22T01:59:29ZengElsevierPediatrics and Neonatology1875-95722013-08-0154422823410.1016/j.pedneo.2013.03.001The Preterm Lung and Airway: Past, Present, and FutureRichard J. MartinAvroy A. FanaroffThe tremendous advancement that has occurred in neonatal intensive care over the last 40–50 years can be largely attributed to greater understanding of developmental pathobiology in the newborn lung. Nonetheless, this improved survival from respiratory distress syndrome has been associated with continuing longer-term morbidity in the form of bronchopulmonary dysplasia (BPD). As a result, neonatal lung injury is a renewed focus of scientific interest. The onset of such an injury may begin in the delivery room, and this has generated interest in minimizing oxygen therapy and aggressive ventilatory support during the transition from fetal to neonatal lung. Fortunately, antenatal steroid therapy and selective use of surfactant therapy are now widely practiced, although fine tuning of this therapy for selected populations is ongoing. Newer therapeutic approaches address many aspects of BPD, including the pro-inflammatory component that characterizes this disorder. Finally, there is a greater need to understand the epidemiology and pathogenesis of the longer-term respiratory morbidity, most notably asthma, that persists in the preterm survivors of neonatal intensive care.http://www.sciencedirect.com/science/article/pii/S1875957213000363bronchopulmonary dysplasianeonatal lung injuryneonatal respiratory therapy |
| spellingShingle | Richard J. Martin Avroy A. Fanaroff The Preterm Lung and Airway: Past, Present, and Future Pediatrics and Neonatology bronchopulmonary dysplasia neonatal lung injury neonatal respiratory therapy |
| title | The Preterm Lung and Airway: Past, Present, and Future |
| title_full | The Preterm Lung and Airway: Past, Present, and Future |
| title_fullStr | The Preterm Lung and Airway: Past, Present, and Future |
| title_full_unstemmed | The Preterm Lung and Airway: Past, Present, and Future |
| title_short | The Preterm Lung and Airway: Past, Present, and Future |
| title_sort | preterm lung and airway past present and future |
| topic | bronchopulmonary dysplasia neonatal lung injury neonatal respiratory therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1875957213000363 |
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