Chemometric Study of the Correlation between Human Exposure to Benzene and PAHs and Urinary Excretion of Oxidative Stress Biomarkers
Urban air contains benzene and polycyclic aromatic hydrocarbons (PAHs) which have carcinogenic properties. The objective of this paper is to study the correlation of exposure biomarkers with biomarkers of nucleic acid oxidation also considering smoking. In 322 subjects, seven urinary dose biomarkers...
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MDPI AG
2020-12-01
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| Series: | Atmosphere |
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| Online Access: | https://www.mdpi.com/2073-4433/11/12/1341 |
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| author | Flavia Buonaurio Enrico Paci Daniela Pigini Federico Marini Lisa Bauleo Carla Ancona Giovanna Tranfo |
| author_facet | Flavia Buonaurio Enrico Paci Daniela Pigini Federico Marini Lisa Bauleo Carla Ancona Giovanna Tranfo |
| author_sort | Flavia Buonaurio |
| collection | DOAJ |
| description | Urban air contains benzene and polycyclic aromatic hydrocarbons (PAHs) which have carcinogenic properties. The objective of this paper is to study the correlation of exposure biomarkers with biomarkers of nucleic acid oxidation also considering smoking. In 322 subjects, seven urinary dose biomarkers were analyzed for benzene, pyrene, nitropyrene, benzo[a]pyrene, and naphthalene exposure, and four effect biomarkers for nucleic acid and protein oxidative stress. Chemometrics was applied in order to investigate the existence of a synergistic effect for the exposure to the mixture and the contribution of active smoking. There is a significant difference between nicotine, benzene and PAH exposure biomarker concentrations of smokers and non-smokers, but the difference is not statistically significant for oxidative stress biomarkers. The PAH biomarkers are those which best correlate with all the oxidative stress biomarkers. Results suggest that 8-Oxo-7,8-dihydroguanine and protein nitro-oxidation 3-nitrotyrosine are the most sensitive biomarkers for the exposure to the urban pollutant mixtures and that a synergic effect of the mixtures exists. All the oxidative stress biomarkers studied drive the increase in the oxidative stress biomarkers in the subjects having higher exposures. Chemometrics proved to be a powerful method for the interpretation of human biomonitoring data. |
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| format | Article |
| id | doaj.art-29913d18c6364b63bf9ded198121e953 |
| institution | Directory Open Access Journal |
| issn | 2073-4433 |
| language | English |
| last_indexed | 2024-03-10T14:09:30Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
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| series | Atmosphere |
| spelling | doaj.art-29913d18c6364b63bf9ded198121e9532023-11-21T00:18:04ZengMDPI AGAtmosphere2073-44332020-12-011112134110.3390/atmos11121341Chemometric Study of the Correlation between Human Exposure to Benzene and PAHs and Urinary Excretion of Oxidative Stress BiomarkersFlavia Buonaurio0Enrico Paci1Daniela Pigini2Federico Marini3Lisa Bauleo4Carla Ancona5Giovanna Tranfo6Department of Analytical Chemistry, Sapienza University, Piazzale Aldo Moro, 5, 00185 Rome, ItalyINAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Via di Fontana Candida 1, 00078 Monte Porzio Catone (RM), ItalyINAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Via di Fontana Candida 1, 00078 Monte Porzio Catone (RM), ItalyDepartment of Analytical Chemistry, Sapienza University, Piazzale Aldo Moro, 5, 00185 Rome, ItalyDepartment of Epidemiology Lazio Regional Health Service, Via Cristoforo Colombo, 112, 00154 Rome, ItalyDepartment of Epidemiology Lazio Regional Health Service, Via Cristoforo Colombo, 112, 00154 Rome, ItalyINAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Via di Fontana Candida 1, 00078 Monte Porzio Catone (RM), ItalyUrban air contains benzene and polycyclic aromatic hydrocarbons (PAHs) which have carcinogenic properties. The objective of this paper is to study the correlation of exposure biomarkers with biomarkers of nucleic acid oxidation also considering smoking. In 322 subjects, seven urinary dose biomarkers were analyzed for benzene, pyrene, nitropyrene, benzo[a]pyrene, and naphthalene exposure, and four effect biomarkers for nucleic acid and protein oxidative stress. Chemometrics was applied in order to investigate the existence of a synergistic effect for the exposure to the mixture and the contribution of active smoking. There is a significant difference between nicotine, benzene and PAH exposure biomarker concentrations of smokers and non-smokers, but the difference is not statistically significant for oxidative stress biomarkers. The PAH biomarkers are those which best correlate with all the oxidative stress biomarkers. Results suggest that 8-Oxo-7,8-dihydroguanine and protein nitro-oxidation 3-nitrotyrosine are the most sensitive biomarkers for the exposure to the urban pollutant mixtures and that a synergic effect of the mixtures exists. All the oxidative stress biomarkers studied drive the increase in the oxidative stress biomarkers in the subjects having higher exposures. Chemometrics proved to be a powerful method for the interpretation of human biomonitoring data.https://www.mdpi.com/2073-4433/11/12/1341human biomonitoringinhalation exposureurban pollutioncentral Italyoxidative stresssmoking |
| spellingShingle | Flavia Buonaurio Enrico Paci Daniela Pigini Federico Marini Lisa Bauleo Carla Ancona Giovanna Tranfo Chemometric Study of the Correlation between Human Exposure to Benzene and PAHs and Urinary Excretion of Oxidative Stress Biomarkers Atmosphere human biomonitoring inhalation exposure urban pollution central Italy oxidative stress smoking |
| title | Chemometric Study of the Correlation between Human Exposure to Benzene and PAHs and Urinary Excretion of Oxidative Stress Biomarkers |
| title_full | Chemometric Study of the Correlation between Human Exposure to Benzene and PAHs and Urinary Excretion of Oxidative Stress Biomarkers |
| title_fullStr | Chemometric Study of the Correlation between Human Exposure to Benzene and PAHs and Urinary Excretion of Oxidative Stress Biomarkers |
| title_full_unstemmed | Chemometric Study of the Correlation between Human Exposure to Benzene and PAHs and Urinary Excretion of Oxidative Stress Biomarkers |
| title_short | Chemometric Study of the Correlation between Human Exposure to Benzene and PAHs and Urinary Excretion of Oxidative Stress Biomarkers |
| title_sort | chemometric study of the correlation between human exposure to benzene and pahs and urinary excretion of oxidative stress biomarkers |
| topic | human biomonitoring inhalation exposure urban pollution central Italy oxidative stress smoking |
| url | https://www.mdpi.com/2073-4433/11/12/1341 |
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