Anti-cancer Substances and Safety of Lactic Acid Bacteria in Clinical Treatment

Lactic acid bacteria (LAB) are a kind of Gram-positive bacteria which can colonize in the biological gastrointestinal tract and play a variety of probiotic roles. LAB have a wide range of applications in industry, animal husbandry, planting, food safety, and medical science fields. Previous studies...

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Main Authors: Chaoran Liu, Jiaqi Zheng, Xuan Ou, Yuzhu Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.722052/full
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author Chaoran Liu
Jiaqi Zheng
Xuan Ou
Yuzhu Han
Yuzhu Han
author_facet Chaoran Liu
Jiaqi Zheng
Xuan Ou
Yuzhu Han
Yuzhu Han
author_sort Chaoran Liu
collection DOAJ
description Lactic acid bacteria (LAB) are a kind of Gram-positive bacteria which can colonize in the biological gastrointestinal tract and play a variety of probiotic roles. LAB have a wide range of applications in industry, animal husbandry, planting, food safety, and medical science fields. Previous studies on LAB have typically concentrated on their effects on improving the digestion and absorption of the gastrointestinal tract, regulating the balance of the microflora, and inhibiting the production and accumulation of toxic substances. The resistance of LAB to cancer is a topic of growing interest and relevance. This paper provided a summary of bio-active substances of LAB when they act against cancer, as well as the safety of LAB in clinical cancer treatment. Moreover, this paper further discussed several possible directions for future research and the potential application of LAB as anti-cancer therapy.
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spelling doaj.art-299284fe6e8b48279ca2b7166bbccab72022-12-21T19:28:57ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-10-011210.3389/fmicb.2021.722052722052Anti-cancer Substances and Safety of Lactic Acid Bacteria in Clinical TreatmentChaoran Liu0Jiaqi Zheng1Xuan Ou2Yuzhu Han3Yuzhu Han4College of Animal Science and Technology, Southwest University, Chongqing, ChinaCollege of Animal Science and Technology, Southwest University, Chongqing, ChinaCollege of Animal Science and Technology, Southwest University, Chongqing, ChinaCollege of Animal Science and Technology, Southwest University, Chongqing, ChinaImmunology Research Center, Medical Research Institute, Southwest University, Chongqing, ChinaLactic acid bacteria (LAB) are a kind of Gram-positive bacteria which can colonize in the biological gastrointestinal tract and play a variety of probiotic roles. LAB have a wide range of applications in industry, animal husbandry, planting, food safety, and medical science fields. Previous studies on LAB have typically concentrated on their effects on improving the digestion and absorption of the gastrointestinal tract, regulating the balance of the microflora, and inhibiting the production and accumulation of toxic substances. The resistance of LAB to cancer is a topic of growing interest and relevance. This paper provided a summary of bio-active substances of LAB when they act against cancer, as well as the safety of LAB in clinical cancer treatment. Moreover, this paper further discussed several possible directions for future research and the potential application of LAB as anti-cancer therapy.https://www.frontiersin.org/articles/10.3389/fmicb.2021.722052/fulllactic acid bacteriaanti-cancersubstancesmechanismssafety
spellingShingle Chaoran Liu
Jiaqi Zheng
Xuan Ou
Yuzhu Han
Yuzhu Han
Anti-cancer Substances and Safety of Lactic Acid Bacteria in Clinical Treatment
Frontiers in Microbiology
lactic acid bacteria
anti-cancer
substances
mechanisms
safety
title Anti-cancer Substances and Safety of Lactic Acid Bacteria in Clinical Treatment
title_full Anti-cancer Substances and Safety of Lactic Acid Bacteria in Clinical Treatment
title_fullStr Anti-cancer Substances and Safety of Lactic Acid Bacteria in Clinical Treatment
title_full_unstemmed Anti-cancer Substances and Safety of Lactic Acid Bacteria in Clinical Treatment
title_short Anti-cancer Substances and Safety of Lactic Acid Bacteria in Clinical Treatment
title_sort anti cancer substances and safety of lactic acid bacteria in clinical treatment
topic lactic acid bacteria
anti-cancer
substances
mechanisms
safety
url https://www.frontiersin.org/articles/10.3389/fmicb.2021.722052/full
work_keys_str_mv AT chaoranliu anticancersubstancesandsafetyoflacticacidbacteriainclinicaltreatment
AT jiaqizheng anticancersubstancesandsafetyoflacticacidbacteriainclinicaltreatment
AT xuanou anticancersubstancesandsafetyoflacticacidbacteriainclinicaltreatment
AT yuzhuhan anticancersubstancesandsafetyoflacticacidbacteriainclinicaltreatment
AT yuzhuhan anticancersubstancesandsafetyoflacticacidbacteriainclinicaltreatment