Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity

Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity

Abstract Currently, the humanity is in a fierce battle against various health-related challenges especially those associated with human malignancies. This created the urge to develop potent and selective inhibitors for tumor cells through targeting specific oncogenic proteins possessing crucial role...

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Bibliographic Details
Main Authors:	Wagdy M. Eldehna, Mahmoud A. El Hassab, Zainab M. Elsayed, Tarfah Al-Warhi, Hazem Elkady, Mahmoud F. Abo-Ashour, Mohammed A. S. Abourehab, Ibrahim H. Eissa, Hatem A. Abdel-Aziz
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-07-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-022-15050-8

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