Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis

Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis

Abstract Background PRAME constitutes one of the largest multi-copy gene families in Eutherians, encoding cancer-testis antigens (CTAs) with leucine-rich repeats (LRR) domains, highly expressed in cancer cells and gametogenic germ cells. This study aims to elucidate genetic interactions between two...

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Bibliographic Details
Main Authors: Mingyao Yang, Francisco Diaz, Ana Rita T. Krause, Yuguo Lei, Wan-Sheng Liu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell & Bioscience
Subjects:
Pramex1
Pramel1
Retinoic acid
Sertoli-cell only
Gene interaction
Gametogenesis
Online Access:https://doi.org/10.1186/s13578-024-01212-w

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