Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies
We sought to investigate (1) the characteristics of epileptiform discharge (ED) duration and interdischarge interval (IDI) and (2) the influence of vigilance state on the ED duration and IDI in genetic generalized epilepsy (GGE). In a cohort of patients diagnosed with GGE, 24-h ambulatory EEG record...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2018.00036/full |
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| author | Udaya Seneviratne Udaya Seneviratne Udaya Seneviratne Ray C. Boston Mark J. Cook Wendyl J. D’Souza |
| author_facet | Udaya Seneviratne Udaya Seneviratne Udaya Seneviratne Ray C. Boston Mark J. Cook Wendyl J. D’Souza |
| author_sort | Udaya Seneviratne |
| collection | DOAJ |
| description | We sought to investigate (1) the characteristics of epileptiform discharge (ED) duration and interdischarge interval (IDI) and (2) the influence of vigilance state on the ED duration and IDI in genetic generalized epilepsy (GGE). In a cohort of patients diagnosed with GGE, 24-h ambulatory EEG recordings were performed prospectively. We then tabulated durations, IDI, and vigilance state in relation to all EDs captured on EEGs. We used K-means cluster analysis and finite mixture modeling to quantify and characterize the groups of ED duration and IDI. To investigate the influence of sleep, we calculated the mean, median, and SEM in each population from all subjects for sleep state and wakefulness separately, followed by the Kruskal–Wallis test to compare the groups. We analyzed 4,679 EDs and corresponding IDI from 23 abnormal 24-h ambulatory EEGs. Our analysis defined two populations of ED durations and IDI: short and long. In all populations, both ED durations and IDI were significantly longer in wakefulness. Our results highlight different characteristics of ED populations in GGE and the influence by the sleep–wake cycle. |
| first_indexed | 2024-12-10T03:45:27Z |
| format | Article |
| id | doaj.art-2994e3521b8d45c5988b44dc77ffd2ed |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T03:45:27Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-2994e3521b8d45c5988b44dc77ffd2ed2022-12-22T02:03:27ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-02-01910.3389/fneur.2018.00036313564Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized EpilepsiesUdaya Seneviratne0Udaya Seneviratne1Udaya Seneviratne2Ray C. Boston3Mark J. Cook4Wendyl J. D’Souza5Department of Medicine, St. Vincent’s Hospital, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Neuroscience, Monash Medical Centre, Melbourne, VIC, AustraliaDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, AustraliaDepartment of Medicine, St. Vincent’s Hospital, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Medicine, St. Vincent’s Hospital, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Medicine, St. Vincent’s Hospital, University of Melbourne, Melbourne, VIC, AustraliaWe sought to investigate (1) the characteristics of epileptiform discharge (ED) duration and interdischarge interval (IDI) and (2) the influence of vigilance state on the ED duration and IDI in genetic generalized epilepsy (GGE). In a cohort of patients diagnosed with GGE, 24-h ambulatory EEG recordings were performed prospectively. We then tabulated durations, IDI, and vigilance state in relation to all EDs captured on EEGs. We used K-means cluster analysis and finite mixture modeling to quantify and characterize the groups of ED duration and IDI. To investigate the influence of sleep, we calculated the mean, median, and SEM in each population from all subjects for sleep state and wakefulness separately, followed by the Kruskal–Wallis test to compare the groups. We analyzed 4,679 EDs and corresponding IDI from 23 abnormal 24-h ambulatory EEGs. Our analysis defined two populations of ED durations and IDI: short and long. In all populations, both ED durations and IDI were significantly longer in wakefulness. Our results highlight different characteristics of ED populations in GGE and the influence by the sleep–wake cycle.http://journal.frontiersin.org/article/10.3389/fneur.2018.00036/fullEEGspike-wavedurationcluster analysissleepepileptiform discharge |
| spellingShingle | Udaya Seneviratne Udaya Seneviratne Udaya Seneviratne Ray C. Boston Mark J. Cook Wendyl J. D’Souza Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies Frontiers in Neurology EEG spike-wave duration cluster analysis sleep epileptiform discharge |
| title | Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies |
| title_full | Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies |
| title_fullStr | Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies |
| title_full_unstemmed | Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies |
| title_short | Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies |
| title_sort | characteristics of epileptiform discharge duration and interdischarge interval in genetic generalized epilepsies |
| topic | EEG spike-wave duration cluster analysis sleep epileptiform discharge |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2018.00036/full |
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