Cardiac and Vascular Remodeling After 6 Months of Therapy With Sacubitril/Valsartan: Mechanistic Insights From Advanced Echocardiographic Analysis

Cardiac and Vascular Remodeling After 6 Months of Therapy With Sacubitril/Valsartan: Mechanistic Insights From Advanced Echocardiographic Analysis

BackgroundEffects of Sacubitril/Valsartan (S/V) on left ventricular (LV) mechanics and ventricular-arterial coupling in patients with heart failure with reduced ejection fraction (HFrEF) are not completely understood. The aim of this study was to evaluate both cardiac and vascular remodeling in a gr...

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Bibliographic Details
Main Authors: Sara Monosilio, Domenico Filomena, Federico Luongo, Michele Sannino, Sara Cimino, Matteo Neccia, Marco Valerio Mariani, Lucia Ilaria Birtolo, Giulia Benedetti, Giovanni Tonti, Gianni Pedrizzetti, Carmine Dario Vizza, Viviana Maestrini, Luciano Agati
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
sacubitril/valsartan
echocardiography
speckle-tracking
hemodynamic forces
pressure-volume loop
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.883769/full

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