Mesenchymal stem cells in systemic sclerosis therapy
Systemic sclerosis (SSc) is a rare autoimmune disorder with a high mortality rate. There are still many unknowns concerning the pathophysiology of this disease, due to its clinical heterogeneity. Since there is still no curative treatment, researchers focus on finding novel methods to help the patie...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2020-10-01
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| Series: | Rheumatology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Mesenchymal-stem-cells-in-systemic-sclerosis-therapy,18,42090,1,1.html |
| _version_ | 1818422651687796736 |
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| author | Daniel Witold Dudek Ewa Walczuk Anna Wajda Agnieszka Paradowska-Gorycka |
| author_facet | Daniel Witold Dudek Ewa Walczuk Anna Wajda Agnieszka Paradowska-Gorycka |
| author_sort | Daniel Witold Dudek |
| collection | DOAJ |
| description | Systemic sclerosis (SSc) is a rare autoimmune disorder with a high mortality rate. There are still many unknowns concerning the pathophysiology of this disease, due to its clinical heterogeneity. Since there is still no curative treatment, researchers focus on finding novel methods to help the patients. One of the valid options is cellular therapy, and mesenchymal stem cells (MSCs)-based therapy yields great expectations. These cells possess especially valuable attributes regarding key points of SSc. Nevertheless, the effectiveness and safety of this therapy must undergo a rigorous process of verification.
In preclinical trials, animal models proved to be a valuable source of scientific knowledge regarding SSc. Because of that, it has been possible to test autologous or allogeneic MSCs from various sources in many clinical trials. A lot of aspects still have to be determined to assess their potential in the management of SSc, probably in association with other therapies. |
| first_indexed | 2024-12-14T13:29:39Z |
| format | Article |
| id | doaj.art-29953b1506164ef2ac2328acf5d0298f |
| institution | Directory Open Access Journal |
| issn | 0034-6233 2084-9834 |
| language | English |
| last_indexed | 2024-12-14T13:29:39Z |
| publishDate | 2020-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj.art-29953b1506164ef2ac2328acf5d0298f2022-12-21T22:59:44ZengTermedia Publishing HouseRheumatology0034-62332084-98342020-10-0158532433010.5114/reum.2020.9999542090Mesenchymal stem cells in systemic sclerosis therapyDaniel Witold DudekEwa WalczukAnna WajdaAgnieszka Paradowska-GoryckaSystemic sclerosis (SSc) is a rare autoimmune disorder with a high mortality rate. There are still many unknowns concerning the pathophysiology of this disease, due to its clinical heterogeneity. Since there is still no curative treatment, researchers focus on finding novel methods to help the patients. One of the valid options is cellular therapy, and mesenchymal stem cells (MSCs)-based therapy yields great expectations. These cells possess especially valuable attributes regarding key points of SSc. Nevertheless, the effectiveness and safety of this therapy must undergo a rigorous process of verification. In preclinical trials, animal models proved to be a valuable source of scientific knowledge regarding SSc. Because of that, it has been possible to test autologous or allogeneic MSCs from various sources in many clinical trials. A lot of aspects still have to be determined to assess their potential in the management of SSc, probably in association with other therapies.https://www.termedia.pl/Mesenchymal-stem-cells-in-systemic-sclerosis-therapy,18,42090,1,1.htmlsystemic sclerosis mesenchymal stem cells cell therapy. |
| spellingShingle | Daniel Witold Dudek Ewa Walczuk Anna Wajda Agnieszka Paradowska-Gorycka Mesenchymal stem cells in systemic sclerosis therapy Rheumatology systemic sclerosis mesenchymal stem cells cell therapy. |
| title | Mesenchymal stem cells in systemic sclerosis therapy |
| title_full | Mesenchymal stem cells in systemic sclerosis therapy |
| title_fullStr | Mesenchymal stem cells in systemic sclerosis therapy |
| title_full_unstemmed | Mesenchymal stem cells in systemic sclerosis therapy |
| title_short | Mesenchymal stem cells in systemic sclerosis therapy |
| title_sort | mesenchymal stem cells in systemic sclerosis therapy |
| topic | systemic sclerosis mesenchymal stem cells cell therapy. |
| url | https://www.termedia.pl/Mesenchymal-stem-cells-in-systemic-sclerosis-therapy,18,42090,1,1.html |
| work_keys_str_mv | AT danielwitolddudek mesenchymalstemcellsinsystemicsclerosistherapy AT ewawalczuk mesenchymalstemcellsinsystemicsclerosistherapy AT annawajda mesenchymalstemcellsinsystemicsclerosistherapy AT agnieszkaparadowskagorycka mesenchymalstemcellsinsystemicsclerosistherapy |