Ichthyosis: A Road Model for Skin Research
The understanding of monogenetic disorders of cornification, including the group of diseases called ichthyoses, has expanded greatly in recent years. Studies of the aetiology of more than 50 types of ichthyosis have almost invariably uncovered errors in the biosynthesis of epidermal lipids or struct...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Journals Sweden
2020-03-01
|
| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3433
|
| _version_ | 1798019065900433408 |
|---|---|
| author | Anders Vahlquist Hans Törmä |
| author_facet | Anders Vahlquist Hans Törmä |
| author_sort | Anders Vahlquist |
| collection | DOAJ |
| description | The understanding of monogenetic disorders of cornification, including the group of diseases called ichthyoses, has expanded greatly in recent years. Studies of the aetiology of more than 50 types of ichthyosis have almost invariably uncovered errors in the biosynthesis of epidermal lipids or structural proteins essential for normal skin barrier function. The barrier abnormality per se may elicit epidermal inflammation, hyperproliferation and hyperkeratosis, potentially contributing to the patient’s skin symptoms. Despite this and other new knowledge about pathomechanisms, treatment of ichthyosis often remains unsatisfactory. This review highlights a series of approaches used to elucidate the pathobiology and clinical consequences of different types of ichthyosis, and related diseases with the ultimate goal of finding new and better treatments. |
| first_indexed | 2024-04-11T16:33:28Z |
| format | Article |
| id | doaj.art-2995f841e9b14d26b70a7e4b955c8d47 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-04-11T16:33:28Z |
| publishDate | 2020-03-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-2995f841e9b14d26b70a7e4b955c8d472022-12-22T04:13:54ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572020-03-011007adv0009710.2340/00015555-34335693Ichthyosis: A Road Model for Skin ResearchAnders Vahlquist0Hans Törmä Department of Medical Sciences/Dermatology, Uppsala University, SE-751 85 Uppsala, Sweden. anders.vahlquist@medsci.uu.se. The understanding of monogenetic disorders of cornification, including the group of diseases called ichthyoses, has expanded greatly in recent years. Studies of the aetiology of more than 50 types of ichthyosis have almost invariably uncovered errors in the biosynthesis of epidermal lipids or structural proteins essential for normal skin barrier function. The barrier abnormality per se may elicit epidermal inflammation, hyperproliferation and hyperkeratosis, potentially contributing to the patient’s skin symptoms. Despite this and other new knowledge about pathomechanisms, treatment of ichthyosis often remains unsatisfactory. This review highlights a series of approaches used to elucidate the pathobiology and clinical consequences of different types of ichthyosis, and related diseases with the ultimate goal of finding new and better treatments. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3433 skin ph arci human epidermis keratins ceramides therapy epidermolytic congenital keratinocytes |
| spellingShingle | Anders Vahlquist Hans Törmä Ichthyosis: A Road Model for Skin Research Acta Dermato-Venereologica skin ph arci human epidermis keratins ceramides therapy epidermolytic congenital keratinocytes |
| title | Ichthyosis: A Road Model for Skin Research |
| title_full | Ichthyosis: A Road Model for Skin Research |
| title_fullStr | Ichthyosis: A Road Model for Skin Research |
| title_full_unstemmed | Ichthyosis: A Road Model for Skin Research |
| title_short | Ichthyosis: A Road Model for Skin Research |
| title_sort | ichthyosis a road model for skin research |
| topic | skin ph arci human epidermis keratins ceramides therapy epidermolytic congenital keratinocytes |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3433
|
| work_keys_str_mv | AT andersvahlquist ichthyosisaroadmodelforskinresearch AT hanstorma ichthyosisaroadmodelforskinresearch |