Отдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишки
Background. Сomparative assessment of long-term oncologic outcomes of surgical and combined treatment of patients with upper rectal cancer.Materials and methods. Patients aged > 18 with histologycally verified upper T1–4N0–2M0 rectal cancer were included. In group A patients received neoadjuv...
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| Format: | Article |
| Language: | Russian |
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“ABV-press” Publishing house”, LLC
2016-08-01
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| Series: | Тазовая хирургия и онкология |
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| Online Access: | https://ok.abvpress.ru/jour/article/view/173 |
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| author | Zh. M. Mad’yarov A. O. Rasulov Yu. A. Barsukov S. I. Tkachev D. V. Kuz’michev S. S. Gordeev A. G. Malikhov M. Yu. Fedyanin |
| author_facet | Zh. M. Mad’yarov A. O. Rasulov Yu. A. Barsukov S. I. Tkachev D. V. Kuz’michev S. S. Gordeev A. G. Malikhov M. Yu. Fedyanin |
| author_sort | Zh. M. Mad’yarov |
| collection | DOAJ |
| description | Background. Сomparative assessment of long-term oncologic outcomes of surgical and combined treatment of patients with upper rectal cancer.Materials and methods. Patients aged > 18 with histologycally verified upper T1–4N0–2M0 rectal cancer were included. In group A patients received neoadjuvant chemoradiotherapy 25 Gy in 5 Gy fractions with capecitabine 850 mg/m2 bid per os on radiation days and surgery. In group B patients received surgery alone.Results. From january 2004 to december 2014, we selected 227 archival cases of patients with upper rectal cancer. Group A was 103 patients (45.4 %) in group B – 123 (54.6 %). We traced long-term results of treatment in 217 (96.6 %) patients. In the group A was 98 (95.1 %) patients, in the group B – 119 (96.7 %) patients. Local recurrence occurred in group A – 1 (1.2 %) patient, in group B – 3 (2.5 %) patients (p = 0.413). The frequency of distant metastases developed in group A in 10 (10.2 %) patients and in group B – 15 (12.6 %) patients (p = 0.581). Overall survival in group A was 90.6 %, and the disease-free survival – 89.6 %, in group B – 82.8 % and 81.9 %, respectively (p = 0.46).Conclusions. Surgical treatment of patients with upper rectal cancer stage I–III, in compliance with all oncological principles is justified. |
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| id | doaj.art-299678498fd747dbaf5ffde0d862f7b2 |
| institution | Directory Open Access Journal |
| issn | 2686-9594 |
| language | Russian |
| last_indexed | 2024-03-12T18:41:31Z |
| publishDate | 2016-08-01 |
| publisher | “ABV-press” Publishing house”, LLC |
| record_format | Article |
| series | Тазовая хирургия и онкология |
| spelling | doaj.art-299678498fd747dbaf5ffde0d862f7b22023-08-02T07:48:53Zrus“ABV-press” Publishing house”, LLCТазовая хирургия и онкология2686-95942016-08-0162404610.17650/2220-3478-2016-6-2-40-46148Отдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишкиZh. M. Mad’yarov0A. O. Rasulov1Yu. A. Barsukov2S. I. Tkachev3D. V. Kuz’michev4S. S. Gordeev5A. G. Malikhov6M. Yu. Fedyanin7Department of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaDepartment of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaDepartment of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaDepartment Radiation Oncology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaDepartment of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaDepartment of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaDepartment of ProctologyDepartment of Clinical Pharmacology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, RussiaBackground. Сomparative assessment of long-term oncologic outcomes of surgical and combined treatment of patients with upper rectal cancer.Materials and methods. Patients aged > 18 with histologycally verified upper T1–4N0–2M0 rectal cancer were included. In group A patients received neoadjuvant chemoradiotherapy 25 Gy in 5 Gy fractions with capecitabine 850 mg/m2 bid per os on radiation days and surgery. In group B patients received surgery alone.Results. From january 2004 to december 2014, we selected 227 archival cases of patients with upper rectal cancer. Group A was 103 patients (45.4 %) in group B – 123 (54.6 %). We traced long-term results of treatment in 217 (96.6 %) patients. In the group A was 98 (95.1 %) patients, in the group B – 119 (96.7 %) patients. Local recurrence occurred in group A – 1 (1.2 %) patient, in group B – 3 (2.5 %) patients (p = 0.413). The frequency of distant metastases developed in group A in 10 (10.2 %) patients and in group B – 15 (12.6 %) patients (p = 0.581). Overall survival in group A was 90.6 %, and the disease-free survival – 89.6 %, in group B – 82.8 % and 81.9 %, respectively (p = 0.46).Conclusions. Surgical treatment of patients with upper rectal cancer stage I–III, in compliance with all oncological principles is justified.https://ok.abvpress.ru/jour/article/view/173upper rectal cancercombined treatmentlocal recurensedistant metastasisoveral survivaldisease-free survival |
| spellingShingle | Zh. M. Mad’yarov A. O. Rasulov Yu. A. Barsukov S. I. Tkachev D. V. Kuz’michev S. S. Gordeev A. G. Malikhov M. Yu. Fedyanin Отдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишки Тазовая хирургия и онкология upper rectal cancer combined treatment local recurense distant metastasis overal survival disease-free survival |
| title | Отдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишки |
| title_full | Отдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишки |
| title_fullStr | Отдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишки |
| title_full_unstemmed | Отдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишки |
| title_short | Отдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишки |
| title_sort | отдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишки |
| topic | upper rectal cancer combined treatment local recurense distant metastasis overal survival disease-free survival |
| url | https://ok.abvpress.ru/jour/article/view/173 |
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