Hairy cell leukemia with an aggressive outcome: A case report with a review of the literature
Hairy cell leukemia (HCL), an uncommon cancer affecting B-lymphocytes primarily in the bone marrow and spleen, is identified by abnormal projections on malignant B cells, which give the illness its name. This condition is less frequently observed in Asian populations compared with individuals from A...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | MGM Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.mgmjms.com/article.asp?issn=2347-7946;year=2023;volume=10;issue=4;spage=798;epage=801;aulast=Mashelkarm |
| _version_ | 1797221264006316032 |
|---|---|
| author | Adwaita Mashelkarm Shirish Khatu Prakash Dive S Sudhamani |
| author_facet | Adwaita Mashelkarm Shirish Khatu Prakash Dive S Sudhamani |
| author_sort | Adwaita Mashelkarm |
| collection | DOAJ |
| description | Hairy cell leukemia (HCL), an uncommon cancer affecting B-lymphocytes primarily in the bone marrow and spleen, is identified by abnormal projections on malignant B cells, which give the illness its name. This condition is less frequently observed in Asian populations compared with individuals from American and European backgrounds and tends to be diagnosed around the age of 55 years. The leading genetic association of this ailment is linked to the BRAFV600 mutation. Diagnosing HCL poses challenges due to its similarity to other conditions involving excessive lymphocyte growth. Here, we present a distinctive case of an aggressive disease course in a 46-year-old male. |
| first_indexed | 2024-04-24T13:02:40Z |
| format | Article |
| id | doaj.art-2999c92dcd7940fa8baff6fd1f8a14c8 |
| institution | Directory Open Access Journal |
| issn | 2347-7946 2347-7962 |
| language | English |
| last_indexed | 2024-04-24T13:02:40Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MGM Journal of Medical Sciences |
| spelling | doaj.art-2999c92dcd7940fa8baff6fd1f8a14c82024-04-05T10:12:52ZengWolters Kluwer Medknow PublicationsMGM Journal of Medical Sciences2347-79462347-79622023-01-0110479880110.4103/mgmj.mgmj_142_23Hairy cell leukemia with an aggressive outcome: A case report with a review of the literatureAdwaita MashelkarmShirish KhatuPrakash DiveS SudhamaniHairy cell leukemia (HCL), an uncommon cancer affecting B-lymphocytes primarily in the bone marrow and spleen, is identified by abnormal projections on malignant B cells, which give the illness its name. This condition is less frequently observed in Asian populations compared with individuals from American and European backgrounds and tends to be diagnosed around the age of 55 years. The leading genetic association of this ailment is linked to the BRAFV600 mutation. Diagnosing HCL poses challenges due to its similarity to other conditions involving excessive lymphocyte growth. Here, we present a distinctive case of an aggressive disease course in a 46-year-old male.http://www.mgmjms.com/article.asp?issn=2347-7946;year=2023;volume=10;issue=4;spage=798;epage=801;aulast=Mashelkarmb cell leukemiabraf mutationhairy cellhairy cell leukemia |
| spellingShingle | Adwaita Mashelkarm Shirish Khatu Prakash Dive S Sudhamani Hairy cell leukemia with an aggressive outcome: A case report with a review of the literature MGM Journal of Medical Sciences b cell leukemia braf mutation hairy cell hairy cell leukemia |
| title | Hairy cell leukemia with an aggressive outcome: A case report with a review of the literature |
| title_full | Hairy cell leukemia with an aggressive outcome: A case report with a review of the literature |
| title_fullStr | Hairy cell leukemia with an aggressive outcome: A case report with a review of the literature |
| title_full_unstemmed | Hairy cell leukemia with an aggressive outcome: A case report with a review of the literature |
| title_short | Hairy cell leukemia with an aggressive outcome: A case report with a review of the literature |
| title_sort | hairy cell leukemia with an aggressive outcome a case report with a review of the literature |
| topic | b cell leukemia braf mutation hairy cell hairy cell leukemia |
| url | http://www.mgmjms.com/article.asp?issn=2347-7946;year=2023;volume=10;issue=4;spage=798;epage=801;aulast=Mashelkarm |
| work_keys_str_mv | AT adwaitamashelkarm hairycellleukemiawithanaggressiveoutcomeacasereportwithareviewoftheliterature AT shirishkhatu hairycellleukemiawithanaggressiveoutcomeacasereportwithareviewoftheliterature AT prakashdive hairycellleukemiawithanaggressiveoutcomeacasereportwithareviewoftheliterature AT ssudhamani hairycellleukemiawithanaggressiveoutcomeacasereportwithareviewoftheliterature |