Increased Serum E-Selectin Levels Were Associated with Cognitive Decline in Patients with Stroke

Jin Li,1,* Junqiang Bao,2,* Chao Gao,2 Zibin Wei,2 Liguo Tan,3 Ping Liu,2 Zhiwei Wang,2 Shujuan Tian2 1Department of Neurosurgery, The Affiliated Hospital of the Nco School, The Army Medical University, Shijiazhuang, 050041, Hebei, People’s Republic of China; 2Department of Neurology, The...

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Main Authors: Li J, Bao J, Gao C, Wei Z, Tan L, Liu P, Wang Z, Tian S
Format: Article
Language:English
Published: Dove Medical Press 2021-03-01
Series:International Journal of General Medicine
Subjects:
Online Access:https://www.dovepress.com/increased-serum-e-selectin-levels-were-associated-with-cognitive-decli-peer-reviewed-article-IJGM
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author Li J
Bao J
Gao C
Wei Z
Tan L
Liu P
Wang Z
Tian S
author_facet Li J
Bao J
Gao C
Wei Z
Tan L
Liu P
Wang Z
Tian S
author_sort Li J
collection DOAJ
description Jin Li,1,* Junqiang Bao,2,* Chao Gao,2 Zibin Wei,2 Liguo Tan,3 Ping Liu,2 Zhiwei Wang,2 Shujuan Tian2 1Department of Neurosurgery, The Affiliated Hospital of the Nco School, The Army Medical University, Shijiazhuang, 050041, Hebei, People’s Republic of China; 2Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, 050030, Hebei, People’s Republic of China; 3Department of Field Internal Medicine, The NCO School of The Army Medical University, Shijiazhuang, 050031 Hebei, China*These authors contributed equally to this workCorrespondence: Zhiwei Wang; Shujuan TianDepartment of neurology, The First Hospital of Hebei Medical University, No. 89 Donggang Road, Shijiazhuang, 050030, Hebei, People’s Republic of ChinaEmail wzw0412@163.com; 2581810783@qq.comBackground: Previous studies have reported that patients with stroke have a high incidence of cognitive decline. The aim was to elucidate the association between serum E-selectin levels and cognitive function in stroke patients.Materials and Methods: Serum levels of E-selectin were measured in 322 patients with stroke at baseline. Cox proportional hazard analysis was used to evaluate the predictive value of serum E-selectin for predicting cognitive decline (end point) in patients with stroke.Results: Multivariate linear regression analysis revealed that serum E-selectin levels were independently associated with MOCA score after adjusting for age, gender, BMI, current smoker, current drinker, admission systolic and diastolic BP, CVD history and laboratory measurements in patients with stroke at baseline (Sβ= − 0.156; 95% CI, - 0.170– - 0.074; P< 0.001). The multivariate Cox proportional hazard analysis revealed that serum E-selectin (HR=2.481, 95% CI 1.533– 4.327, P-trend < 0.001) was an independent prognostic factor for cognitive decline in these patients with stroke during the follow-up period.Conclusion: Our results showed that increased serum E-selectin levels were significantly and independently associated with cognitive decline and had independent predictive value for cognitive decline in patients with stroke. Serum E-selectin might enable early recognition of cognitive decline among stroke patients.Keywords: E-selectin, stroke cognitive decline, prognostic value
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spelling doaj.art-299a9065b8674669b985a124949b0a362022-12-21T22:24:51ZengDove Medical PressInternational Journal of General Medicine1178-70742021-03-01Volume 1473373962668Increased Serum E-Selectin Levels Were Associated with Cognitive Decline in Patients with StrokeLi JBao JGao CWei ZTan LLiu PWang ZTian SJin Li,1,* Junqiang Bao,2,* Chao Gao,2 Zibin Wei,2 Liguo Tan,3 Ping Liu,2 Zhiwei Wang,2 Shujuan Tian2 1Department of Neurosurgery, The Affiliated Hospital of the Nco School, The Army Medical University, Shijiazhuang, 050041, Hebei, People’s Republic of China; 2Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, 050030, Hebei, People’s Republic of China; 3Department of Field Internal Medicine, The NCO School of The Army Medical University, Shijiazhuang, 050031 Hebei, China*These authors contributed equally to this workCorrespondence: Zhiwei Wang; Shujuan TianDepartment of neurology, The First Hospital of Hebei Medical University, No. 89 Donggang Road, Shijiazhuang, 050030, Hebei, People’s Republic of ChinaEmail wzw0412@163.com; 2581810783@qq.comBackground: Previous studies have reported that patients with stroke have a high incidence of cognitive decline. The aim was to elucidate the association between serum E-selectin levels and cognitive function in stroke patients.Materials and Methods: Serum levels of E-selectin were measured in 322 patients with stroke at baseline. Cox proportional hazard analysis was used to evaluate the predictive value of serum E-selectin for predicting cognitive decline (end point) in patients with stroke.Results: Multivariate linear regression analysis revealed that serum E-selectin levels were independently associated with MOCA score after adjusting for age, gender, BMI, current smoker, current drinker, admission systolic and diastolic BP, CVD history and laboratory measurements in patients with stroke at baseline (Sβ= − 0.156; 95% CI, - 0.170– - 0.074; P< 0.001). The multivariate Cox proportional hazard analysis revealed that serum E-selectin (HR=2.481, 95% CI 1.533– 4.327, P-trend < 0.001) was an independent prognostic factor for cognitive decline in these patients with stroke during the follow-up period.Conclusion: Our results showed that increased serum E-selectin levels were significantly and independently associated with cognitive decline and had independent predictive value for cognitive decline in patients with stroke. Serum E-selectin might enable early recognition of cognitive decline among stroke patients.Keywords: E-selectin, stroke cognitive decline, prognostic valuehttps://www.dovepress.com/increased-serum-e-selectin-levels-were-associated-with-cognitive-decli-peer-reviewed-article-IJGMe-selectinstroke cognitive declineprognostic value
spellingShingle Li J
Bao J
Gao C
Wei Z
Tan L
Liu P
Wang Z
Tian S
Increased Serum E-Selectin Levels Were Associated with Cognitive Decline in Patients with Stroke
International Journal of General Medicine
e-selectin
stroke cognitive decline
prognostic value
title Increased Serum E-Selectin Levels Were Associated with Cognitive Decline in Patients with Stroke
title_full Increased Serum E-Selectin Levels Were Associated with Cognitive Decline in Patients with Stroke
title_fullStr Increased Serum E-Selectin Levels Were Associated with Cognitive Decline in Patients with Stroke
title_full_unstemmed Increased Serum E-Selectin Levels Were Associated with Cognitive Decline in Patients with Stroke
title_short Increased Serum E-Selectin Levels Were Associated with Cognitive Decline in Patients with Stroke
title_sort increased serum e selectin levels were associated with cognitive decline in patients with stroke
topic e-selectin
stroke cognitive decline
prognostic value
url https://www.dovepress.com/increased-serum-e-selectin-levels-were-associated-with-cognitive-decli-peer-reviewed-article-IJGM
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