Prognostic value of total lesion glycolysis in stage IIIB/IV non–small cell lung cancer
Although positron emission tomography–computed tomography (PET/CT) is widely used for staging, there are limited data available to describe exactly the role of PET/CT metabolic and quantitative parameters for the prediction of disease outcome. A total of 145 patients diagnosed with histology-proven...
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| Format: | Article |
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Turkiye Klinikleri
2017-12-01
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| Series: | Journal of Oncological Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452336417300961 |
| _version_ | 1797922026692804608 |
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| author | Baran Yusufoğlu Cemil Bilir Hüseyin Engin |
| author_facet | Baran Yusufoğlu Cemil Bilir Hüseyin Engin |
| author_sort | Baran Yusufoğlu |
| collection | DOAJ |
| description | Although positron emission tomography–computed tomography (PET/CT) is widely used for staging, there are limited data available to describe exactly the role of PET/CT metabolic and quantitative parameters for the prediction of disease outcome. A total of 145 patients diagnosed with histology-proven lung carcinoma in the advanced stage were included. According to the exclusion criteria remaining 76 patients (41 of them were adenocarcinoma EGFR wild-type, 35 were squamous non-small cell lung cancer (NSCLC)) were analyzed. Maximum standardized uptake value (SUV(max)) of a primary lesion was only statistically significant parameter with progression-free survival (PFS) in regression analyses in the whole study population as well as for overall survival (OS). According to the tumor histology, squamous cell carcinoma group did not have any significant PET CT parameters for PFS and OS, but adenocarcinoma group had significant PET CT parameters which were primary lesion of SUV max, SUV mean, total lesion glycolysis (TLG), mediastinal TLG and whole body TLG. In adenocarcinoma group, patients with lower than median TLG values had significantly increased overall survival than patients having higher median whole body TLG values (median OS was 11 vs 6.5 months, P = 0.031, HR 2.1), also they had more PFS without statistical significance (median PFS 6.5 vs 4 months, P = 0.3 HR 1.2). The present study showed that PET/CT metabolic parameters give some prognostic information other than staging of NSCLC, but this information was only significant in EGFR-wild type adenocarcinoma. For squamous cell carcinoma, we need to find any driver targets. |
| first_indexed | 2024-04-10T14:24:44Z |
| format | Article |
| id | doaj.art-299bfd75ddb3415fa80f24afd85caad7 |
| institution | Directory Open Access Journal |
| issn | 2452-3364 |
| language | English |
| last_indexed | 2024-04-10T14:24:44Z |
| publishDate | 2017-12-01 |
| publisher | Turkiye Klinikleri |
| record_format | Article |
| series | Journal of Oncological Sciences |
| spelling | doaj.art-299bfd75ddb3415fa80f24afd85caad72023-02-15T16:09:09ZengTurkiye KlinikleriJournal of Oncological Sciences2452-33642017-12-013310711110.1016/j.jons.2017.10.003Prognostic value of total lesion glycolysis in stage IIIB/IV non–small cell lung cancerBaran Yusufoğlu0Cemil Bilir1Hüseyin Engin2Recep Tayyip Erdoğan University, Clinic of Nuclear Medicine, Rize, TurkeySakarya University, School of Medicine, Department of Medical Oncology, Sakarya, TurkeyBülent Ecevit University, School of Medicine, Department of Medical Oncology, Zonguldak, TurkeyAlthough positron emission tomography–computed tomography (PET/CT) is widely used for staging, there are limited data available to describe exactly the role of PET/CT metabolic and quantitative parameters for the prediction of disease outcome. A total of 145 patients diagnosed with histology-proven lung carcinoma in the advanced stage were included. According to the exclusion criteria remaining 76 patients (41 of them were adenocarcinoma EGFR wild-type, 35 were squamous non-small cell lung cancer (NSCLC)) were analyzed. Maximum standardized uptake value (SUV(max)) of a primary lesion was only statistically significant parameter with progression-free survival (PFS) in regression analyses in the whole study population as well as for overall survival (OS). According to the tumor histology, squamous cell carcinoma group did not have any significant PET CT parameters for PFS and OS, but adenocarcinoma group had significant PET CT parameters which were primary lesion of SUV max, SUV mean, total lesion glycolysis (TLG), mediastinal TLG and whole body TLG. In adenocarcinoma group, patients with lower than median TLG values had significantly increased overall survival than patients having higher median whole body TLG values (median OS was 11 vs 6.5 months, P = 0.031, HR 2.1), also they had more PFS without statistical significance (median PFS 6.5 vs 4 months, P = 0.3 HR 1.2). The present study showed that PET/CT metabolic parameters give some prognostic information other than staging of NSCLC, but this information was only significant in EGFR-wild type adenocarcinoma. For squamous cell carcinoma, we need to find any driver targets.http://www.sciencedirect.com/science/article/pii/S2452336417300961Total lesion glycolysisSurvivalNon-small cell lung cancerPrognosis |
| spellingShingle | Baran Yusufoğlu Cemil Bilir Hüseyin Engin Prognostic value of total lesion glycolysis in stage IIIB/IV non–small cell lung cancer Journal of Oncological Sciences Total lesion glycolysis Survival Non-small cell lung cancer Prognosis |
| title | Prognostic value of total lesion glycolysis in stage IIIB/IV non–small cell lung cancer |
| title_full | Prognostic value of total lesion glycolysis in stage IIIB/IV non–small cell lung cancer |
| title_fullStr | Prognostic value of total lesion glycolysis in stage IIIB/IV non–small cell lung cancer |
| title_full_unstemmed | Prognostic value of total lesion glycolysis in stage IIIB/IV non–small cell lung cancer |
| title_short | Prognostic value of total lesion glycolysis in stage IIIB/IV non–small cell lung cancer |
| title_sort | prognostic value of total lesion glycolysis in stage iiib iv non small cell lung cancer |
| topic | Total lesion glycolysis Survival Non-small cell lung cancer Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S2452336417300961 |
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