Interactive Relationships between Intestinal Flora and Bile Acids
The digestive tract is replete with complex and diverse microbial communities that are important for the regulation of multiple pathophysiological processes in humans and animals, particularly those involved in the maintenance of intestinal homeostasis, immunity, inflammation, and tumorigenesis. The...
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| author | Xiaohua Guo Edozie Samuel Okpara Wanting Hu Chuyun Yan Yu Wang Qionglin Liang John Y. L. Chiang Shuxin Han |
| author_facet | Xiaohua Guo Edozie Samuel Okpara Wanting Hu Chuyun Yan Yu Wang Qionglin Liang John Y. L. Chiang Shuxin Han |
| author_sort | Xiaohua Guo |
| collection | DOAJ |
| description | The digestive tract is replete with complex and diverse microbial communities that are important for the regulation of multiple pathophysiological processes in humans and animals, particularly those involved in the maintenance of intestinal homeostasis, immunity, inflammation, and tumorigenesis. The diversity of bile acids is a result of the joint efforts of host and intestinal microflora. There is a bidirectional relationship between the microbial community of the intestinal tract and bile acids in that, while the microbial flora tightly modulates the metabolism and synthesis of bile acids, the bile acid pool and composition affect the diversity and the homeostasis of the intestinal flora. Homeostatic imbalances of bile acid and intestinal flora systems may lead to the development of a variety of diseases, such as inflammatory bowel disease (IBD), colorectal cancer (CRC), hepatocellular carcinoma (HCC), type 2 diabetes (T2DM), and polycystic ovary syndrome (PCOS). The interactions between bile acids and intestinal flora may be (in)directly involved in the pathogenesis of these diseases. |
| first_indexed | 2024-03-09T05:21:54Z |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:21:54Z |
| publishDate | 2022-07-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-299c7b7497d945c1bef26b67fe63e4892023-12-03T12:40:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315834310.3390/ijms23158343Interactive Relationships between Intestinal Flora and Bile AcidsXiaohua Guo0Edozie Samuel Okpara1Wanting Hu2Chuyun Yan3Yu Wang4Qionglin Liang5John Y. L. Chiang6Shuxin Han7Department of Hepatobiliary Surgery, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, ChinaDepartment of Hepatobiliary Surgery, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, ChinaMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Lab of Microanalytical Methods & Instrumentation, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing 100084, ChinaDepartment of Hepatobiliary Surgery, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, ChinaMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Lab of Microanalytical Methods & Instrumentation, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Lab of Microanalytical Methods & Instrumentation, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing 100084, ChinaDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USADepartment of Hepatobiliary Surgery, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, ChinaThe digestive tract is replete with complex and diverse microbial communities that are important for the regulation of multiple pathophysiological processes in humans and animals, particularly those involved in the maintenance of intestinal homeostasis, immunity, inflammation, and tumorigenesis. The diversity of bile acids is a result of the joint efforts of host and intestinal microflora. There is a bidirectional relationship between the microbial community of the intestinal tract and bile acids in that, while the microbial flora tightly modulates the metabolism and synthesis of bile acids, the bile acid pool and composition affect the diversity and the homeostasis of the intestinal flora. Homeostatic imbalances of bile acid and intestinal flora systems may lead to the development of a variety of diseases, such as inflammatory bowel disease (IBD), colorectal cancer (CRC), hepatocellular carcinoma (HCC), type 2 diabetes (T2DM), and polycystic ovary syndrome (PCOS). The interactions between bile acids and intestinal flora may be (in)directly involved in the pathogenesis of these diseases.https://www.mdpi.com/1422-0067/23/15/8343bile acidsintestinal florahomeostatic imbalancesdiseasesinteractions |
| spellingShingle | Xiaohua Guo Edozie Samuel Okpara Wanting Hu Chuyun Yan Yu Wang Qionglin Liang John Y. L. Chiang Shuxin Han Interactive Relationships between Intestinal Flora and Bile Acids International Journal of Molecular Sciences bile acids intestinal flora homeostatic imbalances diseases interactions |
| title | Interactive Relationships between Intestinal Flora and Bile Acids |
| title_full | Interactive Relationships between Intestinal Flora and Bile Acids |
| title_fullStr | Interactive Relationships between Intestinal Flora and Bile Acids |
| title_full_unstemmed | Interactive Relationships between Intestinal Flora and Bile Acids |
| title_short | Interactive Relationships between Intestinal Flora and Bile Acids |
| title_sort | interactive relationships between intestinal flora and bile acids |
| topic | bile acids intestinal flora homeostatic imbalances diseases interactions |
| url | https://www.mdpi.com/1422-0067/23/15/8343 |
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