Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes
Troponin I is a biomarker for cardiac injury in children. The role of troponin I in neonatal Hypoxic–Ischemic encephalopathy (HIE) may have valuable clinical implications. Troponin I levels were measured within 6 h of birth to determine their relationship to HIE stage, short-term cardiac functional...
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MDPI AG
2021-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/17/4010 |
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| author | Inn-Chi Lee Chin-Sheng Yu Swee-Hee Wong Ko-Huang Lue |
| author_facet | Inn-Chi Lee Chin-Sheng Yu Swee-Hee Wong Ko-Huang Lue |
| author_sort | Inn-Chi Lee |
| collection | DOAJ |
| description | Troponin I is a biomarker for cardiac injury in children. The role of troponin I in neonatal Hypoxic–Ischemic encephalopathy (HIE) may have valuable clinical implications. Troponin I levels were measured within 6 h of birth to determine their relationship to HIE stage, short-term cardiac functional outcomes, and neurodevelopmental outcomes at 1 year. Seventy-three patients were divided into two groups: mild HIE and moderate to severe HIE. Troponin I levels within 6 h of birth were obtained in 61 patients, and were significantly higher in patients with moderate to severe HIE than in patients with mild HIE (Mann–Whitney U test, U = 146, <i>p =</i> 0.001). A troponin I cut-off level of ≥60 pg/mL predicted moderate to severe HIE with a specificity of 81.1% and a negative prediction rate of 76.9%. A troponin I cut-off level of ≥180 pg/mL was significantly (χ<sup>2</sup> (1, <i>n</i> = 61) = 33.1, <i>p</i> = 0.001, odds ratio 96.8) related with hypotension during first admission and significantly (χ<sup>2</sup> (1, <i>n</i> = 61) = 5.3, <i>p</i> = 0.021, odds ratio 4.53) related with abnormal neurodevelopmental outcomes at 1 year. Early troponin I level may be a useful biomarker for predicting moderate to severe HIE, and initialization of hypothermia therapy. |
| first_indexed | 2024-03-10T08:08:33Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T08:08:33Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-299ddb289dbc4b428377f86ede18783c2023-11-22T10:50:43ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011017401010.3390/jcm10174010Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental OutcomesInn-Chi Lee0Chin-Sheng Yu1Swee-Hee Wong2Ko-Huang Lue3Division of Pediatric Neurology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, TaiwanMaster’s Program in Biomedical Informatics and Biomedical Engineering, Department of Information Engineering and Computer Science, Feng Chia University, Taichung 407, TaiwanDivision of Pediatric Neurology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, TaiwanInstitute of Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, TaiwanTroponin I is a biomarker for cardiac injury in children. The role of troponin I in neonatal Hypoxic–Ischemic encephalopathy (HIE) may have valuable clinical implications. Troponin I levels were measured within 6 h of birth to determine their relationship to HIE stage, short-term cardiac functional outcomes, and neurodevelopmental outcomes at 1 year. Seventy-three patients were divided into two groups: mild HIE and moderate to severe HIE. Troponin I levels within 6 h of birth were obtained in 61 patients, and were significantly higher in patients with moderate to severe HIE than in patients with mild HIE (Mann–Whitney U test, U = 146, <i>p =</i> 0.001). A troponin I cut-off level of ≥60 pg/mL predicted moderate to severe HIE with a specificity of 81.1% and a negative prediction rate of 76.9%. A troponin I cut-off level of ≥180 pg/mL was significantly (χ<sup>2</sup> (1, <i>n</i> = 61) = 33.1, <i>p</i> = 0.001, odds ratio 96.8) related with hypotension during first admission and significantly (χ<sup>2</sup> (1, <i>n</i> = 61) = 5.3, <i>p</i> = 0.021, odds ratio 4.53) related with abnormal neurodevelopmental outcomes at 1 year. Early troponin I level may be a useful biomarker for predicting moderate to severe HIE, and initialization of hypothermia therapy.https://www.mdpi.com/2077-0383/10/17/4010newbornHIEbiomarkertroponin I |
| spellingShingle | Inn-Chi Lee Chin-Sheng Yu Swee-Hee Wong Ko-Huang Lue Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes Journal of Clinical Medicine newborn HIE biomarker troponin I |
| title | Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes |
| title_full | Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes |
| title_fullStr | Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes |
| title_full_unstemmed | Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes |
| title_short | Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes |
| title_sort | troponin i levels in neonatal hypoxic ischemic encephalopathy are related to cardiopulmonary comorbidity and neurodevelopmental outcomes |
| topic | newborn HIE biomarker troponin I |
| url | https://www.mdpi.com/2077-0383/10/17/4010 |
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