Leptin Promotes Greater Ki67 Expression in CD4+ T Cells From Obese Compared to Lean Persons Living With HIV

Leptin Promotes Greater Ki67 Expression in CD4+ T Cells From Obese Compared to Lean Persons Living With HIV

While antiretroviral therapy (ART) has proven effective in suppressing viremia and disease progression among people living with human immunodeficiency virus (HIV; PLWH), suboptimal CD4+ T cell reconstitution remains a major obstacle in nearly 30% of ART-treated individuals. Epidemiological studies d...

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Bibliographic Details
Main Authors: Hubaida Fuseini, Rita Smith, Cindy H. Nochowicz, Joshua D. Simmons, LaToya Hannah, Celestine N. Wanjalla, Curtis L. Gabriel, Mona Mashayekhi, Samuel S. Bailin, Jessica L. Castilho, Alyssa H. Hasty, John R. Koethe, Spyros A. Kalams
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
leptin
body mass index
obesity
HIV
CD4+ T cell
Ki67
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.796898/full

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