Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton
Herpes simplex virus type 1 (HSV-1) is a neuroinvasive human pathogen that has the ability to infect and replicate within epithelial cells and neurons and establish a life-long latent infection in sensory neurons. HSV-1 depends on the host cellular cytoskeleton for entry, replication, and exit. Ther...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-02-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/10/2/92 |
| _version_ | 1818253432860966912 |
|---|---|
| author | Monica Miranda-Saksena Christopher E. Denes Russell J. Diefenbach Anthony L. Cunningham |
| author_facet | Monica Miranda-Saksena Christopher E. Denes Russell J. Diefenbach Anthony L. Cunningham |
| author_sort | Monica Miranda-Saksena |
| collection | DOAJ |
| description | Herpes simplex virus type 1 (HSV-1) is a neuroinvasive human pathogen that has the ability to infect and replicate within epithelial cells and neurons and establish a life-long latent infection in sensory neurons. HSV-1 depends on the host cellular cytoskeleton for entry, replication, and exit. Therefore, HSV-1 has adapted mechanisms to promote its survival by exploiting the microtubule and actin cytoskeletons to direct its active transport, infection, and spread between neurons and epithelial cells during primary and recurrent infections. This review will focus on the currently known mechanisms utilized by HSV-1 to harness the neuronal cytoskeleton, molecular motors, and the secretory and exocytic pathways for efficient virus entry, axonal transport, replication, assembly, and exit from the distinct functional compartments (cell body and axon) of the highly polarized sensory neurons. |
| first_indexed | 2024-12-12T16:39:59Z |
| format | Article |
| id | doaj.art-299f11ab3c57466f9397158e79fc670c |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-12T16:39:59Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-299f11ab3c57466f9397158e79fc670c2022-12-22T00:18:35ZengMDPI AGViruses1999-49152018-02-011029210.3390/v10020092v10020092Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the CytoskeletonMonica Miranda-Saksena0Christopher E. Denes1Russell J. Diefenbach2Anthony L. Cunningham3Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead NSW 2145, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead NSW 2145, AustraliaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney NSW 2109, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead NSW 2145, AustraliaHerpes simplex virus type 1 (HSV-1) is a neuroinvasive human pathogen that has the ability to infect and replicate within epithelial cells and neurons and establish a life-long latent infection in sensory neurons. HSV-1 depends on the host cellular cytoskeleton for entry, replication, and exit. Therefore, HSV-1 has adapted mechanisms to promote its survival by exploiting the microtubule and actin cytoskeletons to direct its active transport, infection, and spread between neurons and epithelial cells during primary and recurrent infections. This review will focus on the currently known mechanisms utilized by HSV-1 to harness the neuronal cytoskeleton, molecular motors, and the secretory and exocytic pathways for efficient virus entry, axonal transport, replication, assembly, and exit from the distinct functional compartments (cell body and axon) of the highly polarized sensory neurons.http://www.mdpi.com/1999-4915/10/2/92herpes simplex virusneuronsaxonal transportcytoskeletonmicrotubulesactin |
| spellingShingle | Monica Miranda-Saksena Christopher E. Denes Russell J. Diefenbach Anthony L. Cunningham Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton Viruses herpes simplex virus neurons axonal transport cytoskeleton microtubules actin |
| title | Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton |
| title_full | Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton |
| title_fullStr | Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton |
| title_full_unstemmed | Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton |
| title_short | Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton |
| title_sort | infection and transport of herpes simplex virus type 1 in neurons role of the cytoskeleton |
| topic | herpes simplex virus neurons axonal transport cytoskeleton microtubules actin |
| url | http://www.mdpi.com/1999-4915/10/2/92 |
| work_keys_str_mv | AT monicamirandasaksena infectionandtransportofherpessimplexvirustype1inneuronsroleofthecytoskeleton AT christopheredenes infectionandtransportofherpessimplexvirustype1inneuronsroleofthecytoskeleton AT russelljdiefenbach infectionandtransportofherpessimplexvirustype1inneuronsroleofthecytoskeleton AT anthonylcunningham infectionandtransportofherpessimplexvirustype1inneuronsroleofthecytoskeleton |