Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications
Colorectal cancer is one of the most common gastrointestinal malignancies in humans, affecting approximately 1.8 million people worldwide. This disease has a major social impact and high treatment costs. Animal models allow us to understand and follow the colon cancer progression; thus, in vivo stud...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/8/4/59 |
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| author | Elisabete Nascimento-Gonçalves Bruno A.L. Mendes Rita Silva-Reis Ana I. Faustino-Rocha Adelina Gama Paula A. Oliveira |
| author_facet | Elisabete Nascimento-Gonçalves Bruno A.L. Mendes Rita Silva-Reis Ana I. Faustino-Rocha Adelina Gama Paula A. Oliveira |
| author_sort | Elisabete Nascimento-Gonçalves |
| collection | DOAJ |
| description | Colorectal cancer is one of the most common gastrointestinal malignancies in humans, affecting approximately 1.8 million people worldwide. This disease has a major social impact and high treatment costs. Animal models allow us to understand and follow the colon cancer progression; thus, in vivo studies are essential to improve and discover new ways of prevention and treatment. Dietary natural products have been under investigation for better and natural prevention, envisioning to show their potential. This manuscript intends to provide the readers a review of rodent colorectal cancer models available in the literature, highlighting their advantages and disadvantages, as well as their potential in the evaluation of several drugs and natural compounds’ effects on colorectal cancer. |
| first_indexed | 2024-03-10T12:35:29Z |
| format | Article |
| id | doaj.art-299f81d9f2504683a4e6fd6d8afe61ec |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T12:35:29Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-299f81d9f2504683a4e6fd6d8afe61ec2023-11-21T14:15:33ZengMDPI AGVeterinary Sciences2306-73812021-04-01845910.3390/vetsci8040059Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their ApplicationsElisabete Nascimento-Gonçalves0Bruno A.L. Mendes1Rita Silva-Reis2Ana I. Faustino-Rocha3Adelina Gama4Paula A. Oliveira5Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalCenter for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalCenter for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalCenter for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalDepartment of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalCenter for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalColorectal cancer is one of the most common gastrointestinal malignancies in humans, affecting approximately 1.8 million people worldwide. This disease has a major social impact and high treatment costs. Animal models allow us to understand and follow the colon cancer progression; thus, in vivo studies are essential to improve and discover new ways of prevention and treatment. Dietary natural products have been under investigation for better and natural prevention, envisioning to show their potential. This manuscript intends to provide the readers a review of rodent colorectal cancer models available in the literature, highlighting their advantages and disadvantages, as well as their potential in the evaluation of several drugs and natural compounds’ effects on colorectal cancer.https://www.mdpi.com/2306-7381/8/4/59spontaneous modelsinduced modelsgenetically engineered models |
| spellingShingle | Elisabete Nascimento-Gonçalves Bruno A.L. Mendes Rita Silva-Reis Ana I. Faustino-Rocha Adelina Gama Paula A. Oliveira Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications Veterinary Sciences spontaneous models induced models genetically engineered models |
| title | Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications |
| title_full | Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications |
| title_fullStr | Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications |
| title_full_unstemmed | Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications |
| title_short | Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications |
| title_sort | animal models of colorectal cancer from spontaneous to genetically engineered models and their applications |
| topic | spontaneous models induced models genetically engineered models |
| url | https://www.mdpi.com/2306-7381/8/4/59 |
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