Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering
The development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement of life quality. This review work focused on versatile biomaterials based on nanocomposites comprising organic polymers and a class of layered inorganic nanoparticles, aiming for drug...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/2/413 |
| _version_ | 1827755974490849280 |
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| author | Vera Regina Leopoldo Constantino Mariana Pires Figueiredo Vagner Roberto Magri Denise Eulálio Vanessa Roberta Rodrigues Cunha Ana Clecia Santos Alcântara Gustavo Frigi Perotti |
| author_facet | Vera Regina Leopoldo Constantino Mariana Pires Figueiredo Vagner Roberto Magri Denise Eulálio Vanessa Roberta Rodrigues Cunha Ana Clecia Santos Alcântara Gustavo Frigi Perotti |
| author_sort | Vera Regina Leopoldo Constantino |
| collection | DOAJ |
| description | The development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement of life quality. This review work focused on versatile biomaterials based on nanocomposites comprising organic polymers and a class of layered inorganic nanoparticles, aiming for drug delivery (oral, transdermal, and ocular delivery) and tissue engineering (skin and bone therapies). Layered double hydroxides (LDHs) are 2D nanomaterials that can intercalate anionic bioactive species between the layers. The layers can hold metal cations that confer intrinsic biological activity to LDHs as well as biocompatibility. The intercalation of bioactive species between the layers allows the formation of drug delivery systems with elevated loading capacity and modified release profiles promoted by ion exchange and/or solubilization. The capacity of tissue integration, antigenicity, and stimulation of collagen formation, among other beneficial characteristics of LDH, have been observed by in vivo assays. The association between the properties of biocompatible polymers and LDH-drug nanohybrids produces multifunctional nanocomposites compatible with living matter. Such nanocomposites are stimuli-responsive, show appropriate mechanical properties, and can be prepared by creative methods that allow a fine-tuning of drug release. They are processed in the end form of films, beads, gels, monoliths etc., to reach orientated therapeutic applications. Several studies attest to the higher performance of polymer/LDH-drug nanocomposite compared to the LDH-drug hybrid or the free drug. |
| first_indexed | 2024-03-11T08:16:37Z |
| format | Article |
| id | doaj.art-29a0c39d2a2949dea4d9146c5a38ab82 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T08:16:37Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-29a0c39d2a2949dea4d9146c5a38ab822023-11-16T22:39:36ZengMDPI AGPharmaceutics1999-49232023-01-0115241310.3390/pharmaceutics15020413Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue EngineeringVera Regina Leopoldo Constantino0Mariana Pires Figueiredo1Vagner Roberto Magri2Denise Eulálio3Vanessa Roberta Rodrigues Cunha4Ana Clecia Santos Alcântara5Gustavo Frigi Perotti6Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, CEP 05513-970, São Paulo 05513-970, SP, BrazilDepartamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, CEP 05513-970, São Paulo 05513-970, SP, BrazilDepartamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, CEP 05513-970, São Paulo 05513-970, SP, BrazilDepartamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, CEP 05513-970, São Paulo 05513-970, SP, BrazilInstituto Federal de Educação, Ciência e Tecnologia de Mato Grosso (IFMT), Linha J, s/n–Zona Rural, Juína 78320-000, MT, BrazilDepartamento de Química, Universidade Federal do Maranhão, São Luís 65080-805, MA, BrazilInstituto de Ciências Exatas e Tecnologia, Universidade Federal do Amazonas, Rua Nossa Senhora do Rosário, 3863, Itacoatiara 69103-128, AM, BrazilThe development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement of life quality. This review work focused on versatile biomaterials based on nanocomposites comprising organic polymers and a class of layered inorganic nanoparticles, aiming for drug delivery (oral, transdermal, and ocular delivery) and tissue engineering (skin and bone therapies). Layered double hydroxides (LDHs) are 2D nanomaterials that can intercalate anionic bioactive species between the layers. The layers can hold metal cations that confer intrinsic biological activity to LDHs as well as biocompatibility. The intercalation of bioactive species between the layers allows the formation of drug delivery systems with elevated loading capacity and modified release profiles promoted by ion exchange and/or solubilization. The capacity of tissue integration, antigenicity, and stimulation of collagen formation, among other beneficial characteristics of LDH, have been observed by in vivo assays. The association between the properties of biocompatible polymers and LDH-drug nanohybrids produces multifunctional nanocomposites compatible with living matter. Such nanocomposites are stimuli-responsive, show appropriate mechanical properties, and can be prepared by creative methods that allow a fine-tuning of drug release. They are processed in the end form of films, beads, gels, monoliths etc., to reach orientated therapeutic applications. Several studies attest to the higher performance of polymer/LDH-drug nanocomposite compared to the LDH-drug hybrid or the free drug.https://www.mdpi.com/1999-4923/15/2/413nanocompositeslayered double hydroxideshydrotalciteanionic clayslayered materialsintercalation compounds |
| spellingShingle | Vera Regina Leopoldo Constantino Mariana Pires Figueiredo Vagner Roberto Magri Denise Eulálio Vanessa Roberta Rodrigues Cunha Ana Clecia Santos Alcântara Gustavo Frigi Perotti Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering Pharmaceutics nanocomposites layered double hydroxides hydrotalcite anionic clays layered materials intercalation compounds |
| title | Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering |
| title_full | Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering |
| title_fullStr | Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering |
| title_full_unstemmed | Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering |
| title_short | Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering |
| title_sort | biomaterials based on organic polymers and layered double hydroxides nanocomposites drug delivery and tissue engineering |
| topic | nanocomposites layered double hydroxides hydrotalcite anionic clays layered materials intercalation compounds |
| url | https://www.mdpi.com/1999-4923/15/2/413 |
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