Dmp53, basket and drICE gene knockdown and polyphenol gallic acid increase life span and locomotor activity in a Drosophila Parkinson's disease model

Dmp53, basket and drICE gene knockdown and polyphenol gallic acid increase life span and locomotor activity in a Drosophila Parkinson's disease model

Understanding the mechanism(s) by which dopaminergic (DAergic) neurons are eroded in Parkinson's disease (PD) is critical for effective therapeutic strategies. By using the binary tyrosine hydroxylase (TH)-Gal4/UAS-X RNAi Drosophila melanogaster system, we report that Dmp53, basket and drICE ge...

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Bibliographic Details
Main Authors: Hector Flavio Ortega-Arellano, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2013-01-01
Series:Genetics and Molecular Biology
Subjects:
Basket
Dmp53
Drice
Drosophila
paraquat
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000400020&lng=en&tlng=en

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