Comparison of three scoring methods using the FDA-approved 22C3 immunohistochemistry assay to evaluate PD-L1 expression in breast cancer and their association with clinicopathologic factors

Comparison of three scoring methods using the FDA-approved 22C3 immunohistochemistry assay to evaluate PD-L1 expression in breast cancer and their association with clinicopathologic factors

Abstract Background In the evaluation of PD-L1 expression to select patients for anti-PD-1/PD-L1 treatment, uniform guidelines that account for different immunohistochemistry assays, different cell types and different cutoff values across tumor types are lacking. Data on how different scoring method...

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Bibliographic Details
Main Authors: Hua Guo, Qingqing Ding, Yun Gong, Michael Z. Gilcrease, Min Zhao, Jun Zhao, Dawen Sui, Yun Wu, Hui Chen, Hui Liu, Jinxia Zhang, Erika Resetkova, Stacy L. Moulder, Wei-Lien Wang, Lei Huo
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Breast Cancer Research
Subjects:
PD-L1
22C3
Immunohistochemistry
Scoring methods
Breast cancer
Tumor-infiltrating lymphocytes
Online Access:http://link.springer.com/article/10.1186/s13058-020-01303-9

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