The influence of chronic helicobacter pylori infection on some serum lipid profile parameters, apolipoproteins A-I and B and Lp(a) lipoprotein
Data on proatherogenic lipid profile alterations due to chronic Helicobacter pylori (HP) infection are contradictory. Aim of this study was to examine the differences in some lipid parameters between 55 subjects of both gender with a chronic HP infection (IgG>50 U/mL and IgA <20 U/mL) and 55 g...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2009-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2009/1452-82580901022K.pdf |
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| author | Kojić-Damjanov Sunčica Đerić Mirjana Eremić Nevena Čabarkapa Velibor |
| author_facet | Kojić-Damjanov Sunčica Đerić Mirjana Eremić Nevena Čabarkapa Velibor |
| author_sort | Kojić-Damjanov Sunčica |
| collection | DOAJ |
| description | Data on proatherogenic lipid profile alterations due to chronic Helicobacter pylori (HP) infection are contradictory. Aim of this study was to examine the differences in some lipid parameters between 55 subjects of both gender with a chronic HP infection (IgG>50 U/mL and IgA <20 U/mL) and 55 gender matched HP seronegative subjects (IgG and IgA <20 U/mL). Total cholesterol (TC) (p<0.001), triglycerides (TG) (p<0.05), LDL-cholesterol (LDL-C)(p<0.02), non-HDL-cholesterol (non-HDL-C), apolipoprotein (apo) B (p<0.001), Lp(a) and HDL-cholesterol (HDL-C) serum levels were higher in HP seropositive than in seronegative subjects, while there were almost no differences in apo A-I. In HP seropositive subjects, the frequency of pathological TC (p<0.001), TG (p<0.05), LDLC (p<0.01), non-HDL-C (p<0.01), apo B (p<0.02) and Lp(a) serum levels was higher compared to seronegative. Serum HP IgG titers correlated negatively with TC, LDL-C (p<0.05), non-HDL-C, apo B and Lp(a) levels, and positively with TG, HDL-C and apo A-I levels. Results are similar for both genders. Our results confirm the hypothesis that a chronic HP infection could modify the lipid profile in a proatherogenic way. |
| first_indexed | 2024-12-10T20:55:39Z |
| format | Article |
| id | doaj.art-29a4728a4a8040cd884063ea15944903 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-10T20:55:39Z |
| publishDate | 2009-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-29a4728a4a8040cd884063ea159449032022-12-22T01:33:58ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662009-01-0128122291452-82580901022KThe influence of chronic helicobacter pylori infection on some serum lipid profile parameters, apolipoproteins A-I and B and Lp(a) lipoproteinKojić-Damjanov Sunčica0Đerić Mirjana1Eremić Nevena2Čabarkapa Velibor3https://orcid.org/0000-0001-7166-3379Center for Laboratory Medicine, Clinical Center of Vojvodina, Novi SadCenter for Laboratory Medicine, Clinical Center of Vojvodina, Novi SadCenter for Laboratory Medicine, Clinical Center of Vojvodina, Novi SadCenter for Laboratory Medicine, Clinical Center of Vojvodina, Novi SadData on proatherogenic lipid profile alterations due to chronic Helicobacter pylori (HP) infection are contradictory. Aim of this study was to examine the differences in some lipid parameters between 55 subjects of both gender with a chronic HP infection (IgG>50 U/mL and IgA <20 U/mL) and 55 gender matched HP seronegative subjects (IgG and IgA <20 U/mL). Total cholesterol (TC) (p<0.001), triglycerides (TG) (p<0.05), LDL-cholesterol (LDL-C)(p<0.02), non-HDL-cholesterol (non-HDL-C), apolipoprotein (apo) B (p<0.001), Lp(a) and HDL-cholesterol (HDL-C) serum levels were higher in HP seropositive than in seronegative subjects, while there were almost no differences in apo A-I. In HP seropositive subjects, the frequency of pathological TC (p<0.001), TG (p<0.05), LDLC (p<0.01), non-HDL-C (p<0.01), apo B (p<0.02) and Lp(a) serum levels was higher compared to seronegative. Serum HP IgG titers correlated negatively with TC, LDL-C (p<0.05), non-HDL-C, apo B and Lp(a) levels, and positively with TG, HDL-C and apo A-I levels. Results are similar for both genders. Our results confirm the hypothesis that a chronic HP infection could modify the lipid profile in a proatherogenic way.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2009/1452-82580901022K.pdfatherosclerosishelicobacter pylorilipidsatherogenic risk |
| spellingShingle | Kojić-Damjanov Sunčica Đerić Mirjana Eremić Nevena Čabarkapa Velibor The influence of chronic helicobacter pylori infection on some serum lipid profile parameters, apolipoproteins A-I and B and Lp(a) lipoprotein Journal of Medical Biochemistry atherosclerosis helicobacter pylori lipids atherogenic risk |
| title | The influence of chronic helicobacter pylori infection on some serum lipid profile parameters, apolipoproteins A-I and B and Lp(a) lipoprotein |
| title_full | The influence of chronic helicobacter pylori infection on some serum lipid profile parameters, apolipoproteins A-I and B and Lp(a) lipoprotein |
| title_fullStr | The influence of chronic helicobacter pylori infection on some serum lipid profile parameters, apolipoproteins A-I and B and Lp(a) lipoprotein |
| title_full_unstemmed | The influence of chronic helicobacter pylori infection on some serum lipid profile parameters, apolipoproteins A-I and B and Lp(a) lipoprotein |
| title_short | The influence of chronic helicobacter pylori infection on some serum lipid profile parameters, apolipoproteins A-I and B and Lp(a) lipoprotein |
| title_sort | influence of chronic helicobacter pylori infection on some serum lipid profile parameters apolipoproteins a i and b and lp a lipoprotein |
| topic | atherosclerosis helicobacter pylori lipids atherogenic risk |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2009/1452-82580901022K.pdf |
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