Dietary Inflammatory Index and Its Relationship with Cervical Carcinogenesis Risk in Korean Women: A Case-Control Study
Several studies have reported that diet’s inflammatory potential is related to chronic diseases such as cancer, but its relationship with cervical cancer risk has not been studied yet. The aim of this study was to investigate the association between Dietary Inflammatory Index (DII<sup&g...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-08-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/8/1108 |
| _version_ | 1797722475731091456 |
|---|---|
| author | Sundara Raj Sreeja Hyun Yi Lee Minji Kwon Nitin Shivappa James R. Hebert Mi Kyung Kim |
| author_facet | Sundara Raj Sreeja Hyun Yi Lee Minji Kwon Nitin Shivappa James R. Hebert Mi Kyung Kim |
| author_sort | Sundara Raj Sreeja |
| collection | DOAJ |
| description | Several studies have reported that diet’s inflammatory potential is related to chronic diseases such as cancer, but its relationship with cervical cancer risk has not been studied yet. The aim of this study was to investigate the association between Dietary Inflammatory Index (DII<sup>®</sup>) and cervical cancer risk among Korean women. This study consisted of 764 cases with cervical intraepithelial neoplasia (CIN)1, 2, 3, or cervical cancer, and 729 controls from six gynecologic oncology clinics in South Korea. The DII was computed using a validated semiquantitative Food Frequency Questionnaire (FFQ). Odds ratios and 95% CI were calculated using multinomial logistic regression. Higher DII scores were associated with higher cervical carcinogenesis risk. A significant association was observed between the DII and risk among CIN2/3 [Odds Ratio (OR) = 3.14; 95% Confidence Intervals (CI) = 1.57−6.29] and cervical cancer patients (OR = 1.98; 95% CI = 1.01−3.88). Among Human Papilloma Virus (HPV)-positive women, a significant association was found between DII and cervical carcinoma risk with CIN2/3 (OR = 5.65; 95% CI = 1.38−23.2). Moreover, women with CIN2/3 and cervical cancer showed a significant association with proinflammatory diet in people without of physical activity (OR = 3.79; 95% CI = 1.81−7.93). These findings suggest that high intake of proinflammatory diets is associated with increased risk of cervical carcinogenesis among women with CIN2/3. Further evaluation in future studies to confirm this association is warranted. |
| first_indexed | 2024-03-12T09:47:54Z |
| format | Article |
| id | doaj.art-29a6674151b14adaab99ee341c0cc7d3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T09:47:54Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-29a6674151b14adaab99ee341c0cc7d32023-09-02T12:45:14ZengMDPI AGCancers2072-66942019-08-01118110810.3390/cancers11081108cancers11081108Dietary Inflammatory Index and Its Relationship with Cervical Carcinogenesis Risk in Korean Women: A Case-Control StudySundara Raj Sreeja0Hyun Yi Lee1Minji Kwon2Nitin Shivappa3James R. Hebert4Mi Kyung Kim5Cancer Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Madu-dong, Ilsan-dong-gu, Goyang-si, Gyeonggi-do 10408, KoreaCancer Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Madu-dong, Ilsan-dong-gu, Goyang-si, Gyeonggi-do 10408, KoreaCancer Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Madu-dong, Ilsan-dong-gu, Goyang-si, Gyeonggi-do 10408, KoreaCancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USACancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USACancer Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Madu-dong, Ilsan-dong-gu, Goyang-si, Gyeonggi-do 10408, KoreaSeveral studies have reported that diet’s inflammatory potential is related to chronic diseases such as cancer, but its relationship with cervical cancer risk has not been studied yet. The aim of this study was to investigate the association between Dietary Inflammatory Index (DII<sup>®</sup>) and cervical cancer risk among Korean women. This study consisted of 764 cases with cervical intraepithelial neoplasia (CIN)1, 2, 3, or cervical cancer, and 729 controls from six gynecologic oncology clinics in South Korea. The DII was computed using a validated semiquantitative Food Frequency Questionnaire (FFQ). Odds ratios and 95% CI were calculated using multinomial logistic regression. Higher DII scores were associated with higher cervical carcinogenesis risk. A significant association was observed between the DII and risk among CIN2/3 [Odds Ratio (OR) = 3.14; 95% Confidence Intervals (CI) = 1.57−6.29] and cervical cancer patients (OR = 1.98; 95% CI = 1.01−3.88). Among Human Papilloma Virus (HPV)-positive women, a significant association was found between DII and cervical carcinoma risk with CIN2/3 (OR = 5.65; 95% CI = 1.38−23.2). Moreover, women with CIN2/3 and cervical cancer showed a significant association with proinflammatory diet in people without of physical activity (OR = 3.79; 95% CI = 1.81−7.93). These findings suggest that high intake of proinflammatory diets is associated with increased risk of cervical carcinogenesis among women with CIN2/3. Further evaluation in future studies to confirm this association is warranted.https://www.mdpi.com/2072-6694/11/8/1108cervical cancerdietary inflammatory indexinflammatory biomarkerscervical intraepithelial neoplasia |
| spellingShingle | Sundara Raj Sreeja Hyun Yi Lee Minji Kwon Nitin Shivappa James R. Hebert Mi Kyung Kim Dietary Inflammatory Index and Its Relationship with Cervical Carcinogenesis Risk in Korean Women: A Case-Control Study Cancers cervical cancer dietary inflammatory index inflammatory biomarkers cervical intraepithelial neoplasia |
| title | Dietary Inflammatory Index and Its Relationship with Cervical Carcinogenesis Risk in Korean Women: A Case-Control Study |
| title_full | Dietary Inflammatory Index and Its Relationship with Cervical Carcinogenesis Risk in Korean Women: A Case-Control Study |
| title_fullStr | Dietary Inflammatory Index and Its Relationship with Cervical Carcinogenesis Risk in Korean Women: A Case-Control Study |
| title_full_unstemmed | Dietary Inflammatory Index and Its Relationship with Cervical Carcinogenesis Risk in Korean Women: A Case-Control Study |
| title_short | Dietary Inflammatory Index and Its Relationship with Cervical Carcinogenesis Risk in Korean Women: A Case-Control Study |
| title_sort | dietary inflammatory index and its relationship with cervical carcinogenesis risk in korean women a case control study |
| topic | cervical cancer dietary inflammatory index inflammatory biomarkers cervical intraepithelial neoplasia |
| url | https://www.mdpi.com/2072-6694/11/8/1108 |
| work_keys_str_mv | AT sundararajsreeja dietaryinflammatoryindexanditsrelationshipwithcervicalcarcinogenesisriskinkoreanwomenacasecontrolstudy AT hyunyilee dietaryinflammatoryindexanditsrelationshipwithcervicalcarcinogenesisriskinkoreanwomenacasecontrolstudy AT minjikwon dietaryinflammatoryindexanditsrelationshipwithcervicalcarcinogenesisriskinkoreanwomenacasecontrolstudy AT nitinshivappa dietaryinflammatoryindexanditsrelationshipwithcervicalcarcinogenesisriskinkoreanwomenacasecontrolstudy AT jamesrhebert dietaryinflammatoryindexanditsrelationshipwithcervicalcarcinogenesisriskinkoreanwomenacasecontrolstudy AT mikyungkim dietaryinflammatoryindexanditsrelationshipwithcervicalcarcinogenesisriskinkoreanwomenacasecontrolstudy |