Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

Abstract Background Resistance to platinum-based chemotherapy remains a great challenge for ovarian cancer treatment. The human let-7 family contains 13 members located on nine different chromosomes, and most members have been implicated in the modulation of drug sensitivity in cancers. Our previous...

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Bibliographic Details
Main Authors: Man Xiao, Jing Cai, Liqiong Cai, Jinghui Jia, Lisha Xie, Ying Zhu, Bangxing Huang, Dongdong Jin, Zehua Wang
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Ovarian Research
Subjects:
Let-7e
Ovarian cancer
Cisplatin
DSB
BRCA1
Rad51
Online Access:http://link.springer.com/article/10.1186/s13048-017-0321-8

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