Remote at-home wearable-based gait assessments in Progressive Supranuclear Palsy compared to Parkinson’s Disease
Abstract Background Wearable sensors can differentiate Progressive Supranuclear Palsy (PSP) from Parkinson’s Disease (PD) in laboratory settings but have not been tested in remote settings. Objectives To compare gait and balance in PSP and PD remotely using wearable-based assessments. Methods Partic...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-023-03466-2 |
| _version_ | 1797388250886701056 |
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| author | Mansi Sharma Ram kinker Mishra Anna J. Hall Jose Casado Rylee Cole Adonay S. Nunes Gregory Barchard Ashkan Vaziri Alexander Pantelyat Anne-Marie Wills |
| author_facet | Mansi Sharma Ram kinker Mishra Anna J. Hall Jose Casado Rylee Cole Adonay S. Nunes Gregory Barchard Ashkan Vaziri Alexander Pantelyat Anne-Marie Wills |
| author_sort | Mansi Sharma |
| collection | DOAJ |
| description | Abstract Background Wearable sensors can differentiate Progressive Supranuclear Palsy (PSP) from Parkinson’s Disease (PD) in laboratory settings but have not been tested in remote settings. Objectives To compare gait and balance in PSP and PD remotely using wearable-based assessments. Methods Participants with probable PSP or probable/clinically established PD with reliable caregivers, still able to ambulate 10 feet unassisted, were recruited, enrolled, and consented remotely and instructed by video conference to operate a study-specific tablet solution (BioDigit Home ™) and to wear three inertial sensors (LEGSys™, BioSensics LLC, Newton, MA USA) while performing the Timed Up and Go, 5 × sit-to-stand, and 2-min walk tests. PSPRS and MDS-UPDRS scores were collected virtually or during routine clinical visits. Results Between November, 2021- November, 2022, 27 participants were screened of whom 3 were excluded because of technological difficulties. Eleven PSP and 12 PD participants enrolled, of whom 10 from each group had complete analyzable data. Demographics were well-matched (PSP mean age = 67.6 ± 1.3 years, 40% female; PD mean age = 70.3 ± 1.8 years, 40% female) while disease duration was significantly shorter in PSP (PSP 14 ± 3.5 months vs PD 87.9 ± 16.9 months). Gait parameters showed significant group differences with effect sizes ranging from d = 1.0 to 2.27. Gait speed was significantly slower in PSP: 0.45 ± 0.06 m/s vs. 0.79 ± 0.06 m/s in PD (d = 1.78, p < 0.001). Conclusion Our study demonstrates the feasibility of measuring gait in PSP and PD remotely using wearable sensors. The study provides insight into digital biomarkers for both neurodegenerative diseases. Trial registration ClinicalTrials.gov Identifier: NCT04753320, first posted Febuary 15, 2021. |
| first_indexed | 2024-03-08T22:37:08Z |
| format | Article |
| id | doaj.art-29a8fbb805694e17a80ca2017c966518 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-08T22:37:08Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-29a8fbb805694e17a80ca2017c9665182023-12-17T12:21:18ZengBMCBMC Neurology1471-23772023-12-012311910.1186/s12883-023-03466-2Remote at-home wearable-based gait assessments in Progressive Supranuclear Palsy compared to Parkinson’s DiseaseMansi Sharma0Ram kinker Mishra1Anna J. Hall2Jose Casado3Rylee Cole4Adonay S. Nunes5Gregory Barchard6Ashkan Vaziri7Alexander Pantelyat8Anne-Marie Wills9Department of Neurology, Massachusetts General Hospital, Harvard Medical SchoolBioSensics LLCDepartment of Neurology, Johns Hopkins University School of MedicineBioSensics LLCBioSensics LLCBioSensics LLCBioSensics LLCBioSensics LLCDepartment of Neurology, Johns Hopkins University School of MedicineDepartment of Neurology, Massachusetts General Hospital, Harvard Medical SchoolAbstract Background Wearable sensors can differentiate Progressive Supranuclear Palsy (PSP) from Parkinson’s Disease (PD) in laboratory settings but have not been tested in remote settings. Objectives To compare gait and balance in PSP and PD remotely using wearable-based assessments. Methods Participants with probable PSP or probable/clinically established PD with reliable caregivers, still able to ambulate 10 feet unassisted, were recruited, enrolled, and consented remotely and instructed by video conference to operate a study-specific tablet solution (BioDigit Home ™) and to wear three inertial sensors (LEGSys™, BioSensics LLC, Newton, MA USA) while performing the Timed Up and Go, 5 × sit-to-stand, and 2-min walk tests. PSPRS and MDS-UPDRS scores were collected virtually or during routine clinical visits. Results Between November, 2021- November, 2022, 27 participants were screened of whom 3 were excluded because of technological difficulties. Eleven PSP and 12 PD participants enrolled, of whom 10 from each group had complete analyzable data. Demographics were well-matched (PSP mean age = 67.6 ± 1.3 years, 40% female; PD mean age = 70.3 ± 1.8 years, 40% female) while disease duration was significantly shorter in PSP (PSP 14 ± 3.5 months vs PD 87.9 ± 16.9 months). Gait parameters showed significant group differences with effect sizes ranging from d = 1.0 to 2.27. Gait speed was significantly slower in PSP: 0.45 ± 0.06 m/s vs. 0.79 ± 0.06 m/s in PD (d = 1.78, p < 0.001). Conclusion Our study demonstrates the feasibility of measuring gait in PSP and PD remotely using wearable sensors. The study provides insight into digital biomarkers for both neurodegenerative diseases. Trial registration ClinicalTrials.gov Identifier: NCT04753320, first posted Febuary 15, 2021.https://doi.org/10.1186/s12883-023-03466-2PSPParkinson’sWearable sensorsTelemedicineRemote |
| spellingShingle | Mansi Sharma Ram kinker Mishra Anna J. Hall Jose Casado Rylee Cole Adonay S. Nunes Gregory Barchard Ashkan Vaziri Alexander Pantelyat Anne-Marie Wills Remote at-home wearable-based gait assessments in Progressive Supranuclear Palsy compared to Parkinson’s Disease BMC Neurology PSP Parkinson’s Wearable sensors Telemedicine Remote |
| title | Remote at-home wearable-based gait assessments in Progressive Supranuclear Palsy compared to Parkinson’s Disease |
| title_full | Remote at-home wearable-based gait assessments in Progressive Supranuclear Palsy compared to Parkinson’s Disease |
| title_fullStr | Remote at-home wearable-based gait assessments in Progressive Supranuclear Palsy compared to Parkinson’s Disease |
| title_full_unstemmed | Remote at-home wearable-based gait assessments in Progressive Supranuclear Palsy compared to Parkinson’s Disease |
| title_short | Remote at-home wearable-based gait assessments in Progressive Supranuclear Palsy compared to Parkinson’s Disease |
| title_sort | remote at home wearable based gait assessments in progressive supranuclear palsy compared to parkinson s disease |
| topic | PSP Parkinson’s Wearable sensors Telemedicine Remote |
| url | https://doi.org/10.1186/s12883-023-03466-2 |
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