Differentiation is accompanied by a progressive loss in transcriptional memory

Differentiation is accompanied by a progressive loss in transcriptional memory

Abstract Background Cell differentiation requires the integration of two opposite processes, a stabilizing cellular memory, especially at the transcriptional scale, and a burst of gene expression variability which follows the differentiation induction. Therefore, the actual capacity of a cell to und...

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Bibliographic Details
Main Authors: Camille Fourneaux, Laëtitia Racine, Catherine Koering, Sébastien Dussurgey, Elodie Vallin, Alice Moussy, Romuald Parmentier, Fanny Brunard, Daniel Stockholm, Laurent Modolo, Franck Picard, Olivier Gandrillon, Andras Paldi, Sandrine Gonin-Giraud
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Biology
Subjects:
Cell differentiation
Gene expression variability
Transcriptome
Sister cells
Transcriptional memory
Online Access:https://doi.org/10.1186/s12915-024-01846-9

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