Effects of homocysteine on nonalcoholic fatty liver related disease: A mendelian randomization study
Background: Since the association of homocysteine and clinical results of observational studies are controversial on non-alcoholic fatty liver related disease, we compute the two-sample Mendelian Randomization (MR) study.Objective: To evaluate whether the plasma level of homocysteine has an effect o...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.1083855/full |
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| author | Pengcheng Chen Ze Yang Ze Yang Lingyun Guo Lingyun Guo Yingfei Huang Yingfei Huang Jingjia Li Xin Chen Xin Chen Xin Chen |
| author_facet | Pengcheng Chen Ze Yang Ze Yang Lingyun Guo Lingyun Guo Yingfei Huang Yingfei Huang Jingjia Li Xin Chen Xin Chen Xin Chen |
| author_sort | Pengcheng Chen |
| collection | DOAJ |
| description | Background: Since the association of homocysteine and clinical results of observational studies are controversial on non-alcoholic fatty liver related disease, we compute the two-sample Mendelian Randomization (MR) study.Objective: To evaluate whether the plasma level of homocysteine has an effect on the risk of Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and Cirrhosis after its progress, we investigated the causal relationships between plasma homocysteine and the three non-alcoholic fatty liver related diseases mentioned above.Design and methods: Summary estimates were elicited from the inverse-variance weighted (IVW) method through 12 single nucleotide polymorphisms (SNPs) which related to the plasma homocysteine, the SNPs were obtained from a large genome-wide association studies (GWAS) of 44,147 European participants. And the summary statistics for the latest and largest GWAS datasets for NAFLD (307576 in total and 1,578 cases), NASH (309055 in total and 99 cases) and Cirrhosis (306145 in total and 826 cases) were collected from Ristey FinnGen website where the association of genetic variations with blood metabolite levels was conducted using comprehensive metabolite profiling. The study was performed through two-sample MR method.Results: The result indicated that the plasma homocysteine is not significantly associated with NAFLD, and its progression, NASH and Cirrhosis.Conclusion: The evidence in this study is quite deficient to support the causal association of the individual plasma homocysteine with NAFLD, NASH and Cirrhosis, the putative of associations is not exist. |
| first_indexed | 2024-04-13T11:11:51Z |
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| language | English |
| last_indexed | 2024-04-13T11:11:51Z |
| publishDate | 2022-12-01 |
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| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-29b031d737964dfca8ea7fae93cc98df2022-12-22T02:49:06ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-12-01910.3389/fmolb.2022.10838551083855Effects of homocysteine on nonalcoholic fatty liver related disease: A mendelian randomization studyPengcheng Chen0Ze Yang1Ze Yang2Lingyun Guo3Lingyun Guo4Yingfei Huang5Yingfei Huang6Jingjia Li7Xin Chen8Xin Chen9Xin Chen10School of Electronics and Information Engineering, Institute of Big Data and Artificial Intelligence in Medicine, Taizhou University, Taizhou, ChinaDepartment of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Biochemistry and Cancer Medicine, International Institutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, ChinaDepartment of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Biochemistry and Cancer Medicine, International Institutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, ChinaDepartment of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Biochemistry and Cancer Medicine, International Institutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, ChinaHuman Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, ChinaSchool of Electronics and Information Engineering, Institute of Big Data and Artificial Intelligence in Medicine, Taizhou University, Taizhou, ChinaSchool of Medicine, Institute of Pharmaceutical Biotechnology, Zhejiang University, Hangzhou, ChinaJoint Institute for Genetics and Genome Medicine, Zhejiang University and University of Toronto, Zhejiang University, Hangzhou, ChinaBackground: Since the association of homocysteine and clinical results of observational studies are controversial on non-alcoholic fatty liver related disease, we compute the two-sample Mendelian Randomization (MR) study.Objective: To evaluate whether the plasma level of homocysteine has an effect on the risk of Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and Cirrhosis after its progress, we investigated the causal relationships between plasma homocysteine and the three non-alcoholic fatty liver related diseases mentioned above.Design and methods: Summary estimates were elicited from the inverse-variance weighted (IVW) method through 12 single nucleotide polymorphisms (SNPs) which related to the plasma homocysteine, the SNPs were obtained from a large genome-wide association studies (GWAS) of 44,147 European participants. And the summary statistics for the latest and largest GWAS datasets for NAFLD (307576 in total and 1,578 cases), NASH (309055 in total and 99 cases) and Cirrhosis (306145 in total and 826 cases) were collected from Ristey FinnGen website where the association of genetic variations with blood metabolite levels was conducted using comprehensive metabolite profiling. The study was performed through two-sample MR method.Results: The result indicated that the plasma homocysteine is not significantly associated with NAFLD, and its progression, NASH and Cirrhosis.Conclusion: The evidence in this study is quite deficient to support the causal association of the individual plasma homocysteine with NAFLD, NASH and Cirrhosis, the putative of associations is not exist.https://www.frontiersin.org/articles/10.3389/fmolb.2022.1083855/fullhomocysteineNAFLDNASHCirrhosismendelian randomization |
| spellingShingle | Pengcheng Chen Ze Yang Ze Yang Lingyun Guo Lingyun Guo Yingfei Huang Yingfei Huang Jingjia Li Xin Chen Xin Chen Xin Chen Effects of homocysteine on nonalcoholic fatty liver related disease: A mendelian randomization study Frontiers in Molecular Biosciences homocysteine NAFLD NASH Cirrhosis mendelian randomization |
| title | Effects of homocysteine on nonalcoholic fatty liver related disease: A mendelian randomization study |
| title_full | Effects of homocysteine on nonalcoholic fatty liver related disease: A mendelian randomization study |
| title_fullStr | Effects of homocysteine on nonalcoholic fatty liver related disease: A mendelian randomization study |
| title_full_unstemmed | Effects of homocysteine on nonalcoholic fatty liver related disease: A mendelian randomization study |
| title_short | Effects of homocysteine on nonalcoholic fatty liver related disease: A mendelian randomization study |
| title_sort | effects of homocysteine on nonalcoholic fatty liver related disease a mendelian randomization study |
| topic | homocysteine NAFLD NASH Cirrhosis mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.1083855/full |
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