The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients
<b>Background:</b> Inflammatory bowel diseases (IBDs) have seen an exponential increase in incidence, particularly among pediatric patients. Psychological stress is a significant risk factor influencing the disease course. This review assesses the interaction between stress and disease p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/5/1361 |
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| author | Oana Belei Diana-Georgiana Basaca Laura Olariu Manuela Pantea Daiana Bozgan Anda Nanu Iuliana Sîrbu Otilia Mărginean Ileana Enătescu |
| author_facet | Oana Belei Diana-Georgiana Basaca Laura Olariu Manuela Pantea Daiana Bozgan Anda Nanu Iuliana Sîrbu Otilia Mărginean Ileana Enătescu |
| author_sort | Oana Belei |
| collection | DOAJ |
| description | <b>Background:</b> Inflammatory bowel diseases (IBDs) have seen an exponential increase in incidence, particularly among pediatric patients. Psychological stress is a significant risk factor influencing the disease course. This review assesses the interaction between stress and disease progression, focusing on articles that quantified inflammatory markers in IBD patients exposed to varying degrees of psychological stress. <b>Methods:</b> A systematic narrative literature review was conducted, focusing on the interaction between IBD and stress among adult and pediatric patients, as well as animal subjects. The research involved searching PubMed, Scopus, Medline, and Cochrane Library databases from 2000 to December 2023. <b>Results:</b> The interplay between the intestinal immunity response, the nervous system, and psychological disorders, known as the gut–brain axis, plays a major role in IBD pathophysiology. Various types of stressors alter gut mucosal integrity through different pathways, increasing gut mucosa permeability and promoting bacterial translocation. A denser microbial load in the gut wall emphasizes cytokine production, worsening the disease course. The risk of developing depression and anxiety is higher in IBD patients compared with the general population, and stress is a significant trigger for inducing acute flares of the disease. <b>Conclusions:</b> Further large studies should be conducted to assess the relationship between stressors, psychological disorders, and their impact on the course of IBD. Clinicians involved in the medical care of IBD patients should aim to implement stress reduction practices in addition to pharmacological therapies. |
| first_indexed | 2024-04-25T00:26:23Z |
| format | Article |
| id | doaj.art-29b2c189b9c44764aaa6571751683b64 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:26:23Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-29b2c189b9c44764aaa6571751683b642024-03-12T16:48:11ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135136110.3390/jcm13051361The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult PatientsOana Belei0Diana-Georgiana Basaca1Laura Olariu2Manuela Pantea3Daiana Bozgan4Anda Nanu5Iuliana Sîrbu6Otilia Mărginean7Ileana Enătescu8First Pediatric Clinic, Disturbances of Growth and Development on Children Research Center, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaFirst Pediatric Clinic, Disturbances of Growth and Development on Children Research Center, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaDepartment of Pediatrics, First Pediatric Clinic, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaTwelfth Department, Neonatology Clinic, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaClinic of Neonatology, “Pius Brânzeu” County Emergency Clinical Hospital, 300723 Timișoara, RomaniaThird Pediatric Clinic, “Louis Țurcanu” Emergency Children Hospital, 300011 Timișoara, RomaniaThird Pediatric Clinic, “Louis Țurcanu” Emergency Children Hospital, 300011 Timișoara, RomaniaFirst Pediatric Clinic, Disturbances of Growth and Development on Children Research Center, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaTwelfth Department, Neonatology Clinic, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania<b>Background:</b> Inflammatory bowel diseases (IBDs) have seen an exponential increase in incidence, particularly among pediatric patients. Psychological stress is a significant risk factor influencing the disease course. This review assesses the interaction between stress and disease progression, focusing on articles that quantified inflammatory markers in IBD patients exposed to varying degrees of psychological stress. <b>Methods:</b> A systematic narrative literature review was conducted, focusing on the interaction between IBD and stress among adult and pediatric patients, as well as animal subjects. The research involved searching PubMed, Scopus, Medline, and Cochrane Library databases from 2000 to December 2023. <b>Results:</b> The interplay between the intestinal immunity response, the nervous system, and psychological disorders, known as the gut–brain axis, plays a major role in IBD pathophysiology. Various types of stressors alter gut mucosal integrity through different pathways, increasing gut mucosa permeability and promoting bacterial translocation. A denser microbial load in the gut wall emphasizes cytokine production, worsening the disease course. The risk of developing depression and anxiety is higher in IBD patients compared with the general population, and stress is a significant trigger for inducing acute flares of the disease. <b>Conclusions:</b> Further large studies should be conducted to assess the relationship between stressors, psychological disorders, and their impact on the course of IBD. Clinicians involved in the medical care of IBD patients should aim to implement stress reduction practices in addition to pharmacological therapies.https://www.mdpi.com/2077-0383/13/5/1361inflammatory bowel diseasestressanxietyintestinal microbiotagut–brain axis |
| spellingShingle | Oana Belei Diana-Georgiana Basaca Laura Olariu Manuela Pantea Daiana Bozgan Anda Nanu Iuliana Sîrbu Otilia Mărginean Ileana Enătescu The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients Journal of Clinical Medicine inflammatory bowel disease stress anxiety intestinal microbiota gut–brain axis |
| title | The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients |
| title_full | The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients |
| title_fullStr | The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients |
| title_full_unstemmed | The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients |
| title_short | The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients |
| title_sort | interaction between stress and inflammatory bowel disease in pediatric and adult patients |
| topic | inflammatory bowel disease stress anxiety intestinal microbiota gut–brain axis |
| url | https://www.mdpi.com/2077-0383/13/5/1361 |
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