In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates
Verapamil, was assayed to record its modulating effect upon Brazilian Plasmodium falciparum isolates resistant to chloroquine. Other cardiovascular drugs known to be modulating agents in resistant malaria and/or multidrug-resistant neoplasias, including nifedipine, nitrendipine, diltiazem and propra...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2003-01-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000100002&tlng=en |
| _version_ | 1811245543888781312 |
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| author | Carla M.S. Menezes Karin Kirchgatter Sílvia M. Di Santi Carine Savalli Fabíola G. Monteiro Gilberto A. Paula Elizabeth I. Ferreira |
| author_facet | Carla M.S. Menezes Karin Kirchgatter Sílvia M. Di Santi Carine Savalli Fabíola G. Monteiro Gilberto A. Paula Elizabeth I. Ferreira |
| author_sort | Carla M.S. Menezes |
| collection | DOAJ |
| description | Verapamil, was assayed to record its modulating effect upon Brazilian Plasmodium falciparum isolates resistant to chloroquine. Other cardiovascular drugs known to be modulating agents in resistant malaria and/or multidrug-resistant neoplasias, including nifedipine, nitrendipine, diltiazem and propranolol, were also evaluated. Concentrations similar to those for cardiovascular therapy were used in the in vitro microtechnique for antimalarial drug susceptibility. Intrinsic antiplasmodial activity was observed from the lowest concentrations without a significant modulating action. Other reported modulating agents, such as the antipsychotic drug trifluoperazine and the antidepressants desipramine and imipramine, demonstrated similar responses under the same experimental conditions. Results suggest a much higher susceptibility of Brazilian strains, as well as an indifferent behaviour in relation to modulating agents. |
| first_indexed | 2024-04-12T14:40:28Z |
| format | Article |
| id | doaj.art-29b2c40c4aea41e29b823cc046623826 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T14:40:28Z |
| publishDate | 2003-01-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-29b2c40c4aea41e29b823cc0466238262022-12-22T03:28:51ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492003-01-0136159In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolatesCarla M.S. Menezes0Karin Kirchgatter1Sílvia M. Di Santi2Carine Savalli3Fabíola G. Monteiro4Gilberto A. Paula5Elizabeth I. Ferreira6Universidade de São PauloSuperintendência de Controle de EndemiasSuperintendência de Controle de EndemiasUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloVerapamil, was assayed to record its modulating effect upon Brazilian Plasmodium falciparum isolates resistant to chloroquine. Other cardiovascular drugs known to be modulating agents in resistant malaria and/or multidrug-resistant neoplasias, including nifedipine, nitrendipine, diltiazem and propranolol, were also evaluated. Concentrations similar to those for cardiovascular therapy were used in the in vitro microtechnique for antimalarial drug susceptibility. Intrinsic antiplasmodial activity was observed from the lowest concentrations without a significant modulating action. Other reported modulating agents, such as the antipsychotic drug trifluoperazine and the antidepressants desipramine and imipramine, demonstrated similar responses under the same experimental conditions. Results suggest a much higher susceptibility of Brazilian strains, as well as an indifferent behaviour in relation to modulating agents.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000100002&tlng=enChloroquineMultidrug-resistanceVerapamilModulating agentsReversal agents |
| spellingShingle | Carla M.S. Menezes Karin Kirchgatter Sílvia M. Di Santi Carine Savalli Fabíola G. Monteiro Gilberto A. Paula Elizabeth I. Ferreira In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates Revista da Sociedade Brasileira de Medicina Tropical Chloroquine Multidrug-resistance Verapamil Modulating agents Reversal agents |
| title | In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
| title_full | In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
| title_fullStr | In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
| title_full_unstemmed | In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
| title_short | In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
| title_sort | in vitro evaluation of verapamil and other modulating agents in brazilian chloroquine resistant plasmodium falciparum isolates |
| topic | Chloroquine Multidrug-resistance Verapamil Modulating agents Reversal agents |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000100002&tlng=en |
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