Tracing the evolutionary history of hepatitis B virus genotype H endemic to Mexico
Hepatitis B virus (HBV) spreads efficiently among all human populations worldwide. HBV is classified into ten genotypes (A to J) with their geographic distribution and clinical features. In Mexico, HBV genotype H is the leading cause of hepatitis B and has been detected in indigenous populations, su...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1180931/full |
| _version_ | 1797821481101557760 |
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| author | Alexis Jose-Abrego Alexis Jose-Abrego Sonia Roman Sonia Roman Saul Laguna-Meraz Saul Laguna-Meraz Saul Laguna-Meraz João Renato Rebello-Pinho João Renato Rebello-Pinho Santiago Justo Arevalo Santiago Justo Arevalo Arturo Panduro Arturo Panduro |
| author_facet | Alexis Jose-Abrego Alexis Jose-Abrego Sonia Roman Sonia Roman Saul Laguna-Meraz Saul Laguna-Meraz Saul Laguna-Meraz João Renato Rebello-Pinho João Renato Rebello-Pinho Santiago Justo Arevalo Santiago Justo Arevalo Arturo Panduro Arturo Panduro |
| author_sort | Alexis Jose-Abrego |
| collection | DOAJ |
| description | Hepatitis B virus (HBV) spreads efficiently among all human populations worldwide. HBV is classified into ten genotypes (A to J) with their geographic distribution and clinical features. In Mexico, HBV genotype H is the leading cause of hepatitis B and has been detected in indigenous populations, suggesting that HBV genotype H may be native to Mexico. However, little is known about the evolutionary history of HBV genotype H. Thus, we aimed to determine the age of HBV genotype H in Mexico using molecular dating techniques. Ninety-two HBV sequences of the reverse transcriptase (RT) domain of the polymerase gene (~1,251 bp) were analyzed; 48 were genotype H, 43 were genotype F, and the oldest HBV sequence from America was included as the root. All sequences were aligned, and the most recent common ancestor (TMRCA) time was calculated using the Bayesian Skyline Evolutionary Analysis. Our results estimate a TMRCA for the genotype H in Mexico of 2070.9 (667.5–4489.2) years before the present (YBP). We identified four major diversification events in genotype H, named H1, H2, H3, and H4. The TMRCA of H1 was 1213.0 (253.3–2638.3) YBP, followed by H2 1175.5 (557.5–2424.2) YBP, H3 949.6 (279.3–2105.0) YBP, and H4 1230.5 (336.3, 2756.7) YBP. We estimated that genotype H diverged from its sister genotype F around 8140.8 (1867.5–18012.8) YBP. In conclusion, this study found that genotype H in Mexico has an estimated age of 2070.9 (667.5–4489.2) YBP and has experienced at least four major diversification events since then. |
| first_indexed | 2024-03-13T09:53:19Z |
| format | Article |
| id | doaj.art-29b4300602a64abdb6dc260c38a7cb5b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-13T09:53:19Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-29b4300602a64abdb6dc260c38a7cb5b2023-05-24T04:30:50ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-05-011410.3389/fmicb.2023.11809311180931Tracing the evolutionary history of hepatitis B virus genotype H endemic to MexicoAlexis Jose-Abrego0Alexis Jose-Abrego1Sonia Roman2Sonia Roman3Saul Laguna-Meraz4Saul Laguna-Meraz5Saul Laguna-Meraz6João Renato Rebello-Pinho7João Renato Rebello-Pinho8Santiago Justo Arevalo9Santiago Justo Arevalo10Arturo Panduro11Arturo Panduro12Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco, MexicoHealth Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoDepartment of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco, MexicoHealth Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoDepartment of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco, MexicoHealth Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoMolecular Biology in Medicine Doctorate Program, Guadalajara, MexicoDepartment of Gastroenterology, Institute of Tropical Medicine and School of Medicine, LIM07, University of São Paulo, São Paulo, BrazilHospital Israelita Albert Einstein, São Paulo, BrazilFaculty of Biological Sciences, Ricardo Palma University, Lima, PeruDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, BrazilDepartment of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco, MexicoHealth Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoHepatitis B virus (HBV) spreads efficiently among all human populations worldwide. HBV is classified into ten genotypes (A to J) with their geographic distribution and clinical features. In Mexico, HBV genotype H is the leading cause of hepatitis B and has been detected in indigenous populations, suggesting that HBV genotype H may be native to Mexico. However, little is known about the evolutionary history of HBV genotype H. Thus, we aimed to determine the age of HBV genotype H in Mexico using molecular dating techniques. Ninety-two HBV sequences of the reverse transcriptase (RT) domain of the polymerase gene (~1,251 bp) were analyzed; 48 were genotype H, 43 were genotype F, and the oldest HBV sequence from America was included as the root. All sequences were aligned, and the most recent common ancestor (TMRCA) time was calculated using the Bayesian Skyline Evolutionary Analysis. Our results estimate a TMRCA for the genotype H in Mexico of 2070.9 (667.5–4489.2) years before the present (YBP). We identified four major diversification events in genotype H, named H1, H2, H3, and H4. The TMRCA of H1 was 1213.0 (253.3–2638.3) YBP, followed by H2 1175.5 (557.5–2424.2) YBP, H3 949.6 (279.3–2105.0) YBP, and H4 1230.5 (336.3, 2756.7) YBP. We estimated that genotype H diverged from its sister genotype F around 8140.8 (1867.5–18012.8) YBP. In conclusion, this study found that genotype H in Mexico has an estimated age of 2070.9 (667.5–4489.2) YBP and has experienced at least four major diversification events since then.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1180931/fullhepatitis B virusMexicooriginevolutiongenotype HMesoamerica |
| spellingShingle | Alexis Jose-Abrego Alexis Jose-Abrego Sonia Roman Sonia Roman Saul Laguna-Meraz Saul Laguna-Meraz Saul Laguna-Meraz João Renato Rebello-Pinho João Renato Rebello-Pinho Santiago Justo Arevalo Santiago Justo Arevalo Arturo Panduro Arturo Panduro Tracing the evolutionary history of hepatitis B virus genotype H endemic to Mexico Frontiers in Microbiology hepatitis B virus Mexico origin evolution genotype H Mesoamerica |
| title | Tracing the evolutionary history of hepatitis B virus genotype H endemic to Mexico |
| title_full | Tracing the evolutionary history of hepatitis B virus genotype H endemic to Mexico |
| title_fullStr | Tracing the evolutionary history of hepatitis B virus genotype H endemic to Mexico |
| title_full_unstemmed | Tracing the evolutionary history of hepatitis B virus genotype H endemic to Mexico |
| title_short | Tracing the evolutionary history of hepatitis B virus genotype H endemic to Mexico |
| title_sort | tracing the evolutionary history of hepatitis b virus genotype h endemic to mexico |
| topic | hepatitis B virus Mexico origin evolution genotype H Mesoamerica |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1180931/full |
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