Emergence of microbial resistance against nanoparticles: Mechanisms and strategies
Antimicrobial nanoparticles have gained the status of a new generation of drugs that can kill bacterial pathogens by multiple means; however, nanoparticle resistance acquired by some bacterial pathogens has evoked a cause of concern. Several reports suggested that bacteria can develop nanoparticles,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1102615/full |
| _version_ | 1797942751233310720 |
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| author | Siya Kamat Madhuree Kumari |
| author_facet | Siya Kamat Madhuree Kumari |
| author_sort | Siya Kamat |
| collection | DOAJ |
| description | Antimicrobial nanoparticles have gained the status of a new generation of drugs that can kill bacterial pathogens by multiple means; however, nanoparticle resistance acquired by some bacterial pathogens has evoked a cause of concern. Several reports suggested that bacteria can develop nanoparticles, specifically metal nanoparticle resistance, by mechanisms: nanoparticle transformation-induced oxidative stress, membrane alterations, reversible adaptive resistance, irreversible modifications to cell division, and a change in bacterial motility and resistance. Surface properties, concentration and aggregation of nanoparticles, biofilm forming and metal exclusion capacity, and R plasmid and flagellin synthesis by bacteria are crucial factors in the development of nanoparticle resistance in bacteria. Studies reported the resistance reversal by modifying the surface corona of nanoparticles or inhibiting flagellin production by bacterial pathogens. Furthermore, strict regulation regarding the use and disposal of nano-waste across the globe, the firm knowledge of microbe–nanoparticle interaction, and the regulated disposal of nanoparticles in soil and water is required to prevent microbes from developing nanoparticle resistance. |
| first_indexed | 2024-04-10T20:13:15Z |
| format | Article |
| id | doaj.art-29b4848a2356406f96bc4492c5a42e30 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-10T20:13:15Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-29b4848a2356406f96bc4492c5a42e302023-01-26T08:06:42ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-01-011410.3389/fmicb.2023.11026151102615Emergence of microbial resistance against nanoparticles: Mechanisms and strategiesSiya KamatMadhuree KumariAntimicrobial nanoparticles have gained the status of a new generation of drugs that can kill bacterial pathogens by multiple means; however, nanoparticle resistance acquired by some bacterial pathogens has evoked a cause of concern. Several reports suggested that bacteria can develop nanoparticles, specifically metal nanoparticle resistance, by mechanisms: nanoparticle transformation-induced oxidative stress, membrane alterations, reversible adaptive resistance, irreversible modifications to cell division, and a change in bacterial motility and resistance. Surface properties, concentration and aggregation of nanoparticles, biofilm forming and metal exclusion capacity, and R plasmid and flagellin synthesis by bacteria are crucial factors in the development of nanoparticle resistance in bacteria. Studies reported the resistance reversal by modifying the surface corona of nanoparticles or inhibiting flagellin production by bacterial pathogens. Furthermore, strict regulation regarding the use and disposal of nano-waste across the globe, the firm knowledge of microbe–nanoparticle interaction, and the regulated disposal of nanoparticles in soil and water is required to prevent microbes from developing nanoparticle resistance.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1102615/fullnanoparticlesresistancemicrobesflagellinselection pressure |
| spellingShingle | Siya Kamat Madhuree Kumari Emergence of microbial resistance against nanoparticles: Mechanisms and strategies Frontiers in Microbiology nanoparticles resistance microbes flagellin selection pressure |
| title | Emergence of microbial resistance against nanoparticles: Mechanisms and strategies |
| title_full | Emergence of microbial resistance against nanoparticles: Mechanisms and strategies |
| title_fullStr | Emergence of microbial resistance against nanoparticles: Mechanisms and strategies |
| title_full_unstemmed | Emergence of microbial resistance against nanoparticles: Mechanisms and strategies |
| title_short | Emergence of microbial resistance against nanoparticles: Mechanisms and strategies |
| title_sort | emergence of microbial resistance against nanoparticles mechanisms and strategies |
| topic | nanoparticles resistance microbes flagellin selection pressure |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1102615/full |
| work_keys_str_mv | AT siyakamat emergenceofmicrobialresistanceagainstnanoparticlesmechanismsandstrategies AT madhureekumari emergenceofmicrobialresistanceagainstnanoparticlesmechanismsandstrategies |