Usefulness of Fecal Calprotectin in the Management of Patients with Toxigenic <i>Clostridioides difficile</i>
The availability of highly sensitive molecular tests for the detection of <i>Clostridioides difficile</i> in feces leads to overtreatment of patients who are probably only colonized. In this prospective study, the usefulness of fecal calprotectin (fCP) is evaluated in a cohort of patient...
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MDPI AG
2021-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/8/1627 |
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| author | Cecilia Suarez-Carantoña Argeme Rodriguez-Torres Adrian Viteri-Noel Vicente Pintado Sergio Garcia-Fernandez Daniel Mora-Pimentel Rosa Escudero-Sanchez Fuencisla Martin-Jusdado Santiago Moreno Javier Cobo |
| author_facet | Cecilia Suarez-Carantoña Argeme Rodriguez-Torres Adrian Viteri-Noel Vicente Pintado Sergio Garcia-Fernandez Daniel Mora-Pimentel Rosa Escudero-Sanchez Fuencisla Martin-Jusdado Santiago Moreno Javier Cobo |
| author_sort | Cecilia Suarez-Carantoña |
| collection | DOAJ |
| description | The availability of highly sensitive molecular tests for the detection of <i>Clostridioides difficile</i> in feces leads to overtreatment of patients who are probably only colonized. In this prospective study, the usefulness of fecal calprotectin (fCP) is evaluated in a cohort of patients with detection of toxigenic <i>C. difficile</i> in feces. Patients were classified by an infectious diseases consultant blinded to fCP results into three groups—group I, presumed <i>Clostridioides difficile</i> infection (CDI); group II, doubtful but treated CDI; and group III, presumed <i>C. difficile</i> colonization or self-limited CDI not needing treatment. One hundred and thirty-four patients were included. The median fCP concentrations were 410 (138–815) μg/g in group I, 188 (57–524) μg/g in group II, and 51 (26–97) μg/g in group III (26 cases); <i>p</i> < 0.05 for all comparisons. In forty-five out of 134 cases (33.5%), the fCP concentrations were below 100 µg/g. In conclusion, fCP is low in most patients who do not need treatment against <i>C. difficile</i>, and should be investigated as a potentially useful test in the management of patients with detected toxigenic <i>C. difficile</i>. |
| first_indexed | 2024-03-10T12:23:52Z |
| format | Article |
| id | doaj.art-29b5755e094a48c6b113fdcd2cee4cce |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T12:23:52Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-29b5755e094a48c6b113fdcd2cee4cce2023-11-21T15:10:12ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01108162710.3390/jcm10081627Usefulness of Fecal Calprotectin in the Management of Patients with Toxigenic <i>Clostridioides difficile</i>Cecilia Suarez-Carantoña0Argeme Rodriguez-Torres1Adrian Viteri-Noel2Vicente Pintado3Sergio Garcia-Fernandez4Daniel Mora-Pimentel5Rosa Escudero-Sanchez6Fuencisla Martin-Jusdado7Santiago Moreno8Javier Cobo9Internal Medicine Department, Hospital Ramón y Cajal, CTRA M-607 Colmenar Viejo, Km 9.10, 28034 Madrid, SpainBiochemistry Department, Hospital Ramón y Cajal, CTRA M-607 Colmenar Viejo, Km 9.10, 28034 Madrid, SpainInternal Medicine Department, Hospital Ramón y Cajal, CTRA M-607 Colmenar Viejo, Km 9.10, 28034 Madrid, SpainInfectious Diseases Department, Hospital Ramón y Cajal, CTRA M-607 Colmenar Viejo, Km 9.10, 28034 Madrid, SpainMicrobiology Department, Hospital Ramón y Cajal, CTRA M-607 Colmenar Viejo, Km 9.10, 28034 Madrid, SpainBiochemistry Department, Hospital Ramón y Cajal, CTRA M-607 Colmenar Viejo, Km 9.10, 28034 Madrid, SpainInfectious Diseases Department, Hospital Ramón y Cajal, CTRA M-607 Colmenar Viejo, Km 9.10, 28034 Madrid, SpainBiochemistry Department, Hospital Ramón y Cajal, CTRA M-607 Colmenar Viejo, Km 9.10, 28034 Madrid, SpainInfectious Diseases Department, Hospital Ramón y Cajal, CTRA M-607 Colmenar Viejo, Km 9.10, 28034 Madrid, SpainInfectious Diseases Department, Hospital Ramón y Cajal, CTRA M-607 Colmenar Viejo, Km 9.10, 28034 Madrid, SpainThe availability of highly sensitive molecular tests for the detection of <i>Clostridioides difficile</i> in feces leads to overtreatment of patients who are probably only colonized. In this prospective study, the usefulness of fecal calprotectin (fCP) is evaluated in a cohort of patients with detection of toxigenic <i>C. difficile</i> in feces. Patients were classified by an infectious diseases consultant blinded to fCP results into three groups—group I, presumed <i>Clostridioides difficile</i> infection (CDI); group II, doubtful but treated CDI; and group III, presumed <i>C. difficile</i> colonization or self-limited CDI not needing treatment. One hundred and thirty-four patients were included. The median fCP concentrations were 410 (138–815) μg/g in group I, 188 (57–524) μg/g in group II, and 51 (26–97) μg/g in group III (26 cases); <i>p</i> < 0.05 for all comparisons. In forty-five out of 134 cases (33.5%), the fCP concentrations were below 100 µg/g. In conclusion, fCP is low in most patients who do not need treatment against <i>C. difficile</i>, and should be investigated as a potentially useful test in the management of patients with detected toxigenic <i>C. difficile</i>.https://www.mdpi.com/2077-0383/10/8/1627<i>Clostridioides difficile</i>fecal calprotectin<i>Clostridioides</i> infection |
| spellingShingle | Cecilia Suarez-Carantoña Argeme Rodriguez-Torres Adrian Viteri-Noel Vicente Pintado Sergio Garcia-Fernandez Daniel Mora-Pimentel Rosa Escudero-Sanchez Fuencisla Martin-Jusdado Santiago Moreno Javier Cobo Usefulness of Fecal Calprotectin in the Management of Patients with Toxigenic <i>Clostridioides difficile</i> Journal of Clinical Medicine <i>Clostridioides difficile</i> fecal calprotectin <i>Clostridioides</i> infection |
| title | Usefulness of Fecal Calprotectin in the Management of Patients with Toxigenic <i>Clostridioides difficile</i> |
| title_full | Usefulness of Fecal Calprotectin in the Management of Patients with Toxigenic <i>Clostridioides difficile</i> |
| title_fullStr | Usefulness of Fecal Calprotectin in the Management of Patients with Toxigenic <i>Clostridioides difficile</i> |
| title_full_unstemmed | Usefulness of Fecal Calprotectin in the Management of Patients with Toxigenic <i>Clostridioides difficile</i> |
| title_short | Usefulness of Fecal Calprotectin in the Management of Patients with Toxigenic <i>Clostridioides difficile</i> |
| title_sort | usefulness of fecal calprotectin in the management of patients with toxigenic i clostridioides difficile i |
| topic | <i>Clostridioides difficile</i> fecal calprotectin <i>Clostridioides</i> infection |
| url | https://www.mdpi.com/2077-0383/10/8/1627 |
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