Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers
<p>Abstract</p> <p>Background</p> <p>Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been used to induce side-specific mood changes in volunteers and patients. To clarify inconsistencies between reports that used different stimulation frequencies, we...
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| Format: | Article |
| Language: | English |
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BMC
2002-01-01
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| Series: | BMC Psychiatry |
| Online Access: | http://www.biomedcentral.com/1471-244X/2/1 |
| _version_ | 1824018856399601664 |
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| author | Lappin Julia M Jenkins Jenny Shajahan Polash M Ebmeier Klaus P |
| author_facet | Lappin Julia M Jenkins Jenny Shajahan Polash M Ebmeier Klaus P |
| author_sort | Lappin Julia M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been used to induce side-specific mood changes in volunteers and patients. To clarify inconsistencies between reports that used different stimulation frequencies, we conducted a controlled study with a low (1 Hz) frequency, comparing left with right-sided stimulation</p> <p>Methods</p> <p>Nineteen healthy volunteers received randomised left or right prefrontal rTMS at a frequency of 1 Hz and 100% of motor threshold in two sessions two weeks apart.</p> <p>Results</p> <p>There were significant improvements with TMS for performance in the digit symbol substitution and verbal fluency tests, but no change of mood on a number of measures. There was also a reduction of pulse rate after TMS. The only side-specific TMS-effect was on mean arterial pressure, which decreased pressure after left, but not after right prefrontal TMS.</p> <p>Conclusions</p> <p>Apart from the unexpected and so far unreplicated effect on mean arterial pressure, there were no side-specific effects on mood in volunteers. It is unlikely that a simple laterality model of mood together with the assumed activating effect of higher and 'quenching' effect of lower stimulation frequency can account for the effects of TMS on mood.</p> |
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| format | Article |
| id | doaj.art-29b5bd7ca31f4b0f91799bb4488a7a77 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-19T01:11:44Z |
| publishDate | 2002-01-01 |
| publisher | BMC |
| record_format | Article |
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| spelling | doaj.art-29b5bd7ca31f4b0f91799bb4488a7a772022-12-21T20:42:56ZengBMCBMC Psychiatry1471-244X2002-01-0121110.1186/1471-244X-2-1Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteersLappin Julia MJenkins JennyShajahan Polash MEbmeier Klaus P<p>Abstract</p> <p>Background</p> <p>Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been used to induce side-specific mood changes in volunteers and patients. To clarify inconsistencies between reports that used different stimulation frequencies, we conducted a controlled study with a low (1 Hz) frequency, comparing left with right-sided stimulation</p> <p>Methods</p> <p>Nineteen healthy volunteers received randomised left or right prefrontal rTMS at a frequency of 1 Hz and 100% of motor threshold in two sessions two weeks apart.</p> <p>Results</p> <p>There were significant improvements with TMS for performance in the digit symbol substitution and verbal fluency tests, but no change of mood on a number of measures. There was also a reduction of pulse rate after TMS. The only side-specific TMS-effect was on mean arterial pressure, which decreased pressure after left, but not after right prefrontal TMS.</p> <p>Conclusions</p> <p>Apart from the unexpected and so far unreplicated effect on mean arterial pressure, there were no side-specific effects on mood in volunteers. It is unlikely that a simple laterality model of mood together with the assumed activating effect of higher and 'quenching' effect of lower stimulation frequency can account for the effects of TMS on mood.</p>http://www.biomedcentral.com/1471-244X/2/1 |
| spellingShingle | Lappin Julia M Jenkins Jenny Shajahan Polash M Ebmeier Klaus P Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers BMC Psychiatry |
| title | Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title_full | Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title_fullStr | Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title_full_unstemmed | Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title_short | Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title_sort | right and left prefrontal transcranial magnetic stimulation at 1 hz does not affect mood in healthy volunteers |
| url | http://www.biomedcentral.com/1471-244X/2/1 |
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