The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis
Patients with Parkinson's disease (PD) were often observed with gastrointestinal symptoms, which preceded the onset of motor symptoms. Neuropathology of PD has also been found in the enteric nervous system (ENS). Many studies have reported significant PD-related alterations of gut microbiota. T...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.636545/full |
| _version_ | 1819161011846905856 |
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| author | Ting Shen Ting Shen Yumei Yue Tingting He Tingting He Cong Huang Boyi Qu Wen Lv Hsin-Yi Lai Hsin-Yi Lai Hsin-Yi Lai |
| author_facet | Ting Shen Ting Shen Yumei Yue Tingting He Tingting He Cong Huang Boyi Qu Wen Lv Hsin-Yi Lai Hsin-Yi Lai Hsin-Yi Lai |
| author_sort | Ting Shen |
| collection | DOAJ |
| description | Patients with Parkinson's disease (PD) were often observed with gastrointestinal symptoms, which preceded the onset of motor symptoms. Neuropathology of PD has also been found in the enteric nervous system (ENS). Many studies have reported significant PD-related alterations of gut microbiota. This meta-analysis was performed to evaluate the differences of gut microbiota between patients with PD and healthy controls (HCs) across different geographical regions. We conducted a systematic online search for case-control studies detecting gut microbiota in patients with PD and HCs. Mean difference (MD) and 95% confidence interval (CI) were calculated to access alterations in the abundance of certain microbiota families in PD. Fifteen case-control studies were included in this meta-analysis study. Our results showed significant lower abundance levels of Prevotellaceae (MD = −0.37, 95% CI = −0.62 to −0.11), Faecalibacterium (MD = −0.41, 95% CI: −0.57 to −0.24), and Lachnospiraceae (MD = −0.34, 95% CI = −0.59 to −0.09) in patients with PD compared to HCs. Significant higher abundance level of Bifidobacteriaceae (MD = 0.38, 95%; CI = 0.12 to 0.63), Ruminococcaceae (MD = 0.58, 95% CI = 0.07 to 1.10), Verrucomicrobiaceae (MD = 0.45, 95% CI = 0.21 to 0.69), and Christensenellaceae (MD = 0.20, 95% CI = 0.07 to 0.34) was also found in patients with PD. Thus, shared alterations of certain gut microbiota were detected in patients with PD across different geographical regions. These PD-related gut microbiota dysbiosis might lead to the impairment of short-chain fatty acids (SCFAs) producing process, lipid metabolism, immunoregulatory function, and intestinal permeability, which contribute to the pathogenesis of PD. |
| first_indexed | 2024-12-22T17:05:34Z |
| format | Article |
| id | doaj.art-29b68c96cfdc4a65abf409af4383be60 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-22T17:05:34Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-29b68c96cfdc4a65abf409af4383be602022-12-21T18:19:12ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-02-011310.3389/fnagi.2021.636545636545The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-AnalysisTing Shen0Ting Shen1Yumei Yue2Tingting He3Tingting He4Cong Huang5Boyi Qu6Wen Lv7Hsin-Yi Lai8Hsin-Yi Lai9Hsin-Yi Lai10Department of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaDepartment of Neurology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaDepartment of Sports and Exercise Science, Zhejiang University, Hangzhou, ChinaKey Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaDepartment of Neurology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaDepartment of Neurology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, ChinaPatients with Parkinson's disease (PD) were often observed with gastrointestinal symptoms, which preceded the onset of motor symptoms. Neuropathology of PD has also been found in the enteric nervous system (ENS). Many studies have reported significant PD-related alterations of gut microbiota. This meta-analysis was performed to evaluate the differences of gut microbiota between patients with PD and healthy controls (HCs) across different geographical regions. We conducted a systematic online search for case-control studies detecting gut microbiota in patients with PD and HCs. Mean difference (MD) and 95% confidence interval (CI) were calculated to access alterations in the abundance of certain microbiota families in PD. Fifteen case-control studies were included in this meta-analysis study. Our results showed significant lower abundance levels of Prevotellaceae (MD = −0.37, 95% CI = −0.62 to −0.11), Faecalibacterium (MD = −0.41, 95% CI: −0.57 to −0.24), and Lachnospiraceae (MD = −0.34, 95% CI = −0.59 to −0.09) in patients with PD compared to HCs. Significant higher abundance level of Bifidobacteriaceae (MD = 0.38, 95%; CI = 0.12 to 0.63), Ruminococcaceae (MD = 0.58, 95% CI = 0.07 to 1.10), Verrucomicrobiaceae (MD = 0.45, 95% CI = 0.21 to 0.69), and Christensenellaceae (MD = 0.20, 95% CI = 0.07 to 0.34) was also found in patients with PD. Thus, shared alterations of certain gut microbiota were detected in patients with PD across different geographical regions. These PD-related gut microbiota dysbiosis might lead to the impairment of short-chain fatty acids (SCFAs) producing process, lipid metabolism, immunoregulatory function, and intestinal permeability, which contribute to the pathogenesis of PD.https://www.frontiersin.org/articles/10.3389/fnagi.2021.636545/fullParkinson's diseasenon-motor symptomsgut-brain axisgut microbiotameta-analysis |
| spellingShingle | Ting Shen Ting Shen Yumei Yue Tingting He Tingting He Cong Huang Boyi Qu Wen Lv Hsin-Yi Lai Hsin-Yi Lai Hsin-Yi Lai The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis Frontiers in Aging Neuroscience Parkinson's disease non-motor symptoms gut-brain axis gut microbiota meta-analysis |
| title | The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis |
| title_full | The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis |
| title_fullStr | The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis |
| title_full_unstemmed | The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis |
| title_short | The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis |
| title_sort | association between the gut microbiota and parkinson s disease a meta analysis |
| topic | Parkinson's disease non-motor symptoms gut-brain axis gut microbiota meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.636545/full |
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