Overview of the Assessment of Endothelial Function in Humans
The endothelium is recognized to play an important role in various physiological functions including vascular tone, permeability, anticoagulation, and angiogenesis. Endothelial dysfunction is increasingly recognized to contribute to pathophysiology of many disease states, and depending on the diseas...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2020.542567/full |
| _version_ | 1818130643030114304 |
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| author | Po Ying Chia Po Ying Chia Po Ying Chia Andrew Teo Andrew Teo Tsin Wen Yeo Tsin Wen Yeo Tsin Wen Yeo |
| author_facet | Po Ying Chia Po Ying Chia Po Ying Chia Andrew Teo Andrew Teo Tsin Wen Yeo Tsin Wen Yeo Tsin Wen Yeo |
| author_sort | Po Ying Chia |
| collection | DOAJ |
| description | The endothelium is recognized to play an important role in various physiological functions including vascular tone, permeability, anticoagulation, and angiogenesis. Endothelial dysfunction is increasingly recognized to contribute to pathophysiology of many disease states, and depending on the disease stimuli, mechanisms underlying the endothelial dysfunction may be markedly different. As such, numerous techniques to measure different aspects of endothelial dysfunction have been developed and refined as available technology improves. Current available reviews on quantifying endothelial dysfunction generally concentrate on a single aspect of endothelial function, although diseases may affect more than one aspect of endothelial function. Here, we aim to provide an overview on the techniques available for the assessment of the different aspects of endothelial function in humans, human tissues or cells, namely vascular tone modulation, permeability, anticoagulation and fibrinolysis, and the use of endothelial biomarkers as predictors of outcomes. |
| first_indexed | 2024-12-11T08:08:18Z |
| format | Article |
| id | doaj.art-29b74f7fb9714bfabc76ae10d2fddd29 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-11T08:08:18Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-29b74f7fb9714bfabc76ae10d2fddd292022-12-22T01:14:56ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-10-01710.3389/fmed.2020.542567542567Overview of the Assessment of Endothelial Function in HumansPo Ying Chia0Po Ying Chia1Po Ying Chia2Andrew Teo3Andrew Teo4Tsin Wen Yeo5Tsin Wen Yeo6Tsin Wen Yeo7National Centre for Infectious Diseases, Singapore, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SingaporeDepartment of Infectious Diseases, Tan Tock Seng Hospital, Singapore, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SingaporeDepartment of Medicine and Radiology and Doherty Institute, University of Melbourne, Victoria, VIC, AustraliaNational Centre for Infectious Diseases, Singapore, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SingaporeDepartment of Infectious Diseases, Tan Tock Seng Hospital, Singapore, SingaporeThe endothelium is recognized to play an important role in various physiological functions including vascular tone, permeability, anticoagulation, and angiogenesis. Endothelial dysfunction is increasingly recognized to contribute to pathophysiology of many disease states, and depending on the disease stimuli, mechanisms underlying the endothelial dysfunction may be markedly different. As such, numerous techniques to measure different aspects of endothelial dysfunction have been developed and refined as available technology improves. Current available reviews on quantifying endothelial dysfunction generally concentrate on a single aspect of endothelial function, although diseases may affect more than one aspect of endothelial function. Here, we aim to provide an overview on the techniques available for the assessment of the different aspects of endothelial function in humans, human tissues or cells, namely vascular tone modulation, permeability, anticoagulation and fibrinolysis, and the use of endothelial biomarkers as predictors of outcomes.https://www.frontiersin.org/article/10.3389/fmed.2020.542567/fullendothelial dysfunctiondiagnostic markersbiomarkersmicrovascularmacrovascularvascular tone |
| spellingShingle | Po Ying Chia Po Ying Chia Po Ying Chia Andrew Teo Andrew Teo Tsin Wen Yeo Tsin Wen Yeo Tsin Wen Yeo Overview of the Assessment of Endothelial Function in Humans Frontiers in Medicine endothelial dysfunction diagnostic markers biomarkers microvascular macrovascular vascular tone |
| title | Overview of the Assessment of Endothelial Function in Humans |
| title_full | Overview of the Assessment of Endothelial Function in Humans |
| title_fullStr | Overview of the Assessment of Endothelial Function in Humans |
| title_full_unstemmed | Overview of the Assessment of Endothelial Function in Humans |
| title_short | Overview of the Assessment of Endothelial Function in Humans |
| title_sort | overview of the assessment of endothelial function in humans |
| topic | endothelial dysfunction diagnostic markers biomarkers microvascular macrovascular vascular tone |
| url | https://www.frontiersin.org/article/10.3389/fmed.2020.542567/full |
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