Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration
Background: Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drug–nutrient interaction exists between ginsenoside Re and B-complex vit...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-04-01
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| Series: | Journal of Ginseng Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S122684531630032X |
| _version_ | 1811217497703055360 |
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| author | Yin Bin Chen Yu Fang Wang Wei Hou Ying Ping Wang Sheng Yuan Xiao Yang Yang Fu Jia Wang Si Wen Zheng Pei He Zheng |
| author_facet | Yin Bin Chen Yu Fang Wang Wei Hou Ying Ping Wang Sheng Yuan Xiao Yang Yang Fu Jia Wang Si Wen Zheng Pei He Zheng |
| author_sort | Yin Bin Chen |
| collection | DOAJ |
| description | Background: Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drug–nutrient interaction exists between ginsenoside Re and B-complex vitamins is still unknown. The objective of this study was to simultaneously investigate the effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after their oral administration. The study results will provide valuable theoretical guidance for the combined utilization of ginseng and B-complex vitamins.
Methods: Ginsenoside Re with or without B-complex vitamins was orally administered to mice to evaluate its antifatigue effects and to rats to evaluate its bioavailability. The antifatigue activity was evaluated by the weight-loaded swimming test and biochemical parameters, including hepatic glycogen, plasma urea nitrogen, and blood lactic acid. The concentration of ginsenoside Re in plasma was determined by liquid chromatography–tandem mass spectrometry.
Results: No antifatigue effect of ginsenoside Re was noted when ginsenoside Re in combination with B-complex vitamins was orally administered to mice. B-complex vitamins caused to a reduction in the bioavailability of ginsenoside Re with the area under the concentration–time curve from zero to infinity markedly decreasing from 11,830.85 ± 2,366.47 h·ng/mL to 890.55 ± 372.94 h·ng/mL.
Conclusion: The results suggested that there were pharmacokinetic and pharmacodynamic drug–nutrient interactions between ginsenoside Re and B-complex vitamins. B-complex vitamins can significantly weaken the antifatigue effect and decrease the bioavailability of ginsenoside Re when simultaneously administered orally. |
| first_indexed | 2024-04-12T06:55:47Z |
| format | Article |
| id | doaj.art-29b7a432dbf341f4b6b9e750f994d02d |
| institution | Directory Open Access Journal |
| issn | 1226-8453 |
| language | English |
| last_indexed | 2024-04-12T06:55:47Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ginseng Research |
| spelling | doaj.art-29b7a432dbf341f4b6b9e750f994d02d2022-12-22T03:43:10ZengElsevierJournal of Ginseng Research1226-84532017-04-0141220921410.1016/j.jgr.2016.03.006Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administrationYin Bin Chen0Yu Fang Wang1Wei Hou2Ying Ping Wang3Sheng Yuan Xiao4Yang Yang Fu5Jia Wang6Si Wen Zheng7Pei He Zheng8Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, ChinaInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, ChinaInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, ChinaInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, ChinaInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, ChinaSchool of Life Science of Beijing Institute of Technology, Beijing, ChinaInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, ChinaInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, ChinaInstitute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, ChinaBackground: Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drug–nutrient interaction exists between ginsenoside Re and B-complex vitamins is still unknown. The objective of this study was to simultaneously investigate the effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after their oral administration. The study results will provide valuable theoretical guidance for the combined utilization of ginseng and B-complex vitamins. Methods: Ginsenoside Re with or without B-complex vitamins was orally administered to mice to evaluate its antifatigue effects and to rats to evaluate its bioavailability. The antifatigue activity was evaluated by the weight-loaded swimming test and biochemical parameters, including hepatic glycogen, plasma urea nitrogen, and blood lactic acid. The concentration of ginsenoside Re in plasma was determined by liquid chromatography–tandem mass spectrometry. Results: No antifatigue effect of ginsenoside Re was noted when ginsenoside Re in combination with B-complex vitamins was orally administered to mice. B-complex vitamins caused to a reduction in the bioavailability of ginsenoside Re with the area under the concentration–time curve from zero to infinity markedly decreasing from 11,830.85 ± 2,366.47 h·ng/mL to 890.55 ± 372.94 h·ng/mL. Conclusion: The results suggested that there were pharmacokinetic and pharmacodynamic drug–nutrient interactions between ginsenoside Re and B-complex vitamins. B-complex vitamins can significantly weaken the antifatigue effect and decrease the bioavailability of ginsenoside Re when simultaneously administered orally.http://www.sciencedirect.com/science/article/pii/S122684531630032XantifatigueB-complex vitaminsbioavailabilityginsenoside Reinteraction |
| spellingShingle | Yin Bin Chen Yu Fang Wang Wei Hou Ying Ping Wang Sheng Yuan Xiao Yang Yang Fu Jia Wang Si Wen Zheng Pei He Zheng Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration Journal of Ginseng Research antifatigue B-complex vitamins bioavailability ginsenoside Re interaction |
| title | Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration |
| title_full | Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration |
| title_fullStr | Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration |
| title_full_unstemmed | Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration |
| title_short | Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration |
| title_sort | effect of b complex vitamins on the antifatigue activity and bioavailability of ginsenoside re after oral administration |
| topic | antifatigue B-complex vitamins bioavailability ginsenoside Re interaction |
| url | http://www.sciencedirect.com/science/article/pii/S122684531630032X |
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