Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse.
Pharmacological agents, such as bezafibrate, that activate peroxisome proliferator-activated receptors (PPARs) and PPAR γ coactivator-1α (PGC-1α) pathways have been shown to improve mitochondrial function and energy metabolism. The mitochondrial DNA (mtDNA) mutator mouse is a mouse model of aging th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3433471?pdf=render |
| _version_ | 1811224707032154112 |
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| author | Lloye M Dillon Aline Hida Sofia Garcia Tomas A Prolla Carlos T Moraes |
| author_facet | Lloye M Dillon Aline Hida Sofia Garcia Tomas A Prolla Carlos T Moraes |
| author_sort | Lloye M Dillon |
| collection | DOAJ |
| description | Pharmacological agents, such as bezafibrate, that activate peroxisome proliferator-activated receptors (PPARs) and PPAR γ coactivator-1α (PGC-1α) pathways have been shown to improve mitochondrial function and energy metabolism. The mitochondrial DNA (mtDNA) mutator mouse is a mouse model of aging that harbors a proofreading-deficient mtDNA polymerase γ. These mice develop many features of premature aging including hair loss, anemia, osteoporosis, sarcopenia and decreased lifespan. They also have increased mtDNA mutations and marked mitochondrial dysfunction. We found that mutator mice treated with bezafibrate for 8-months had delayed hair loss and improved skin and spleen aging-like phenotypes. Although we observed an increase in markers of fatty acid oxidation in these tissues, we did not detect a generalized increase in mitochondrial markers. On the other hand, there were no improvements in muscle function or lifespan of the mutator mouse, which we attributed to the rodent-specific hepatomegaly associated with fibrate treatment. These results showed that despite its secondary effects in rodent's liver, bezafibrate was able to improve some of the aging phenotypes in the mutator mouse. Because the associated hepatomegaly is not observed in primates, long-term bezafibrate treatment in humans could have beneficial effects on tissues undergoing chronic bioenergetic-related degeneration. |
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| id | doaj.art-29b7fbb1f9f54d269680d3ff1c8d5bde |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T08:52:32Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-29b7fbb1f9f54d269680d3ff1c8d5bde2022-12-22T03:39:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4433510.1371/journal.pone.0044335Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse.Lloye M DillonAline HidaSofia GarciaTomas A ProllaCarlos T MoraesPharmacological agents, such as bezafibrate, that activate peroxisome proliferator-activated receptors (PPARs) and PPAR γ coactivator-1α (PGC-1α) pathways have been shown to improve mitochondrial function and energy metabolism. The mitochondrial DNA (mtDNA) mutator mouse is a mouse model of aging that harbors a proofreading-deficient mtDNA polymerase γ. These mice develop many features of premature aging including hair loss, anemia, osteoporosis, sarcopenia and decreased lifespan. They also have increased mtDNA mutations and marked mitochondrial dysfunction. We found that mutator mice treated with bezafibrate for 8-months had delayed hair loss and improved skin and spleen aging-like phenotypes. Although we observed an increase in markers of fatty acid oxidation in these tissues, we did not detect a generalized increase in mitochondrial markers. On the other hand, there were no improvements in muscle function or lifespan of the mutator mouse, which we attributed to the rodent-specific hepatomegaly associated with fibrate treatment. These results showed that despite its secondary effects in rodent's liver, bezafibrate was able to improve some of the aging phenotypes in the mutator mouse. Because the associated hepatomegaly is not observed in primates, long-term bezafibrate treatment in humans could have beneficial effects on tissues undergoing chronic bioenergetic-related degeneration.http://europepmc.org/articles/PMC3433471?pdf=render |
| spellingShingle | Lloye M Dillon Aline Hida Sofia Garcia Tomas A Prolla Carlos T Moraes Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. PLoS ONE |
| title | Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. |
| title_full | Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. |
| title_fullStr | Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. |
| title_full_unstemmed | Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. |
| title_short | Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. |
| title_sort | long term bezafibrate treatment improves skin and spleen phenotypes of the mtdna mutator mouse |
| url | http://europepmc.org/articles/PMC3433471?pdf=render |
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