The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance
Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading cause of cancer-related deaths among women worldwide. The main reasons for this poor prognosis are late diagnosis; when the disease is already in an advanced stage, and the frequent development of resistance to...
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Format: | Article |
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MDPI AG
2019-06-01
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Series: | Cancers |
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Online Access: | https://www.mdpi.com/2072-6694/11/6/838 |
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author | Nele Loret Hannelore Denys Philippe Tummers Geert Berx |
author_facet | Nele Loret Hannelore Denys Philippe Tummers Geert Berx |
author_sort | Nele Loret |
collection | DOAJ |
description | Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading cause of cancer-related deaths among women worldwide. The main reasons for this poor prognosis are late diagnosis; when the disease is already in an advanced stage, and the frequent development of resistance to current chemotherapeutic regimens. Growing evidence demonstrates that apart from its role in ovarian cancer progression, epithelial-to-mesenchymal transition (EMT) can promote chemotherapy resistance. In this review, we will highlight the contribution of EMT to the distinct steps of ovarian cancer progression. In addition, we will review the different types of ovarian cancer resistance to therapy with particular attention to EMT-mediated mechanisms such as cell fate transitions, enhancement of cancer cell survival, and upregulation of genes related to drug resistance. Preclinical studies of anti-EMT therapies have yielded promising results. However, before anti-EMT therapies can be effectively implemented in clinical trials, more research is needed to elucidate the mechanisms leading to EMT-induced therapy resistance. |
first_indexed | 2024-03-12T19:49:48Z |
format | Article |
id | doaj.art-29b97788472d437d94cf62c0f8d89fb2 |
institution | Directory Open Access Journal |
issn | 2072-6694 |
language | English |
last_indexed | 2024-03-12T19:49:48Z |
publishDate | 2019-06-01 |
publisher | MDPI AG |
record_format | Article |
series | Cancers |
spelling | doaj.art-29b97788472d437d94cf62c0f8d89fb22023-08-02T03:15:08ZengMDPI AGCancers2072-66942019-06-0111683810.3390/cancers11060838cancers11060838The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy ResistanceNele Loret0Hannelore Denys1Philippe Tummers2Geert Berx3Molecular and Cellular Oncology Laboratory, Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052 Ghent, BelgiumCancer Research Institute Ghent (CRIG), 9000 Ghent, BelgiumCancer Research Institute Ghent (CRIG), 9000 Ghent, BelgiumMolecular and Cellular Oncology Laboratory, Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052 Ghent, BelgiumOvarian cancer is the most lethal of all gynecologic malignancies and the eighth leading cause of cancer-related deaths among women worldwide. The main reasons for this poor prognosis are late diagnosis; when the disease is already in an advanced stage, and the frequent development of resistance to current chemotherapeutic regimens. Growing evidence demonstrates that apart from its role in ovarian cancer progression, epithelial-to-mesenchymal transition (EMT) can promote chemotherapy resistance. In this review, we will highlight the contribution of EMT to the distinct steps of ovarian cancer progression. In addition, we will review the different types of ovarian cancer resistance to therapy with particular attention to EMT-mediated mechanisms such as cell fate transitions, enhancement of cancer cell survival, and upregulation of genes related to drug resistance. Preclinical studies of anti-EMT therapies have yielded promising results. However, before anti-EMT therapies can be effectively implemented in clinical trials, more research is needed to elucidate the mechanisms leading to EMT-induced therapy resistance.https://www.mdpi.com/2072-6694/11/6/838ovarian cancerepithelial-to-mesenchymal transition (EMT)mesenchymal-to-epithelial transition (MET)peritoneal metastasistherapy resistancecancer stem cell (CSC) |
spellingShingle | Nele Loret Hannelore Denys Philippe Tummers Geert Berx The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance Cancers ovarian cancer epithelial-to-mesenchymal transition (EMT) mesenchymal-to-epithelial transition (MET) peritoneal metastasis therapy resistance cancer stem cell (CSC) |
title | The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance |
title_full | The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance |
title_fullStr | The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance |
title_full_unstemmed | The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance |
title_short | The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance |
title_sort | role of epithelial to mesenchymal plasticity in ovarian cancer progression and therapy resistance |
topic | ovarian cancer epithelial-to-mesenchymal transition (EMT) mesenchymal-to-epithelial transition (MET) peritoneal metastasis therapy resistance cancer stem cell (CSC) |
url | https://www.mdpi.com/2072-6694/11/6/838 |
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