Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds
Two salts of the mesoionic compounds 1,4-diphenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-thiol chloride (MC-1) and 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride (MC-2) were synthesized utilizing 1,4-diphenyl-thiosemicarbazide and 5-nitro-2-furoyl chloride as starting...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/3/2023/ |
| _version_ | 1818806501934891008 |
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| author | Petrônio Filgueiras de Athayde-Filho Cledualdo Soares de Oliveira David Peter Harding Bruno Freitas Lira Jorge Gonçalo Fernandes Lorenzo José Pinto Siqueira-Júnior José Maria Barbosa-Filho Vivyanne dos Santos Falcão-Silva |
| author_facet | Petrônio Filgueiras de Athayde-Filho Cledualdo Soares de Oliveira David Peter Harding Bruno Freitas Lira Jorge Gonçalo Fernandes Lorenzo José Pinto Siqueira-Júnior José Maria Barbosa-Filho Vivyanne dos Santos Falcão-Silva |
| author_sort | Petrônio Filgueiras de Athayde-Filho |
| collection | DOAJ |
| description | Two salts of the mesoionic compounds 1,4-diphenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-thiol chloride (MC-1) and 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride (MC-2) were synthesized utilizing 1,4-diphenyl-thiosemicarbazide and 5-nitro-2-furoyl chloride as starting materials. Their structures were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis. These compounds were analyzed for their influence on the effectiveness of norfloxacin, tetracycline, and erythromycin (standard antibiotics) against resistant strains of Staphylococcus aureus. MC-1 and MC-2, at sub-inhibitory concentrations of 16 μg/mL, favourably modulated the antibiotic activity of tetracycline by 16- and 32-fold, respectively (MIC), and that of erythromycin by 4-fold. |
| first_indexed | 2024-12-18T19:10:47Z |
| format | Article |
| id | doaj.art-29ba3d93f3cb46eabacd4fcae0dca87a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T19:10:47Z |
| publishDate | 2011-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-29ba3d93f3cb46eabacd4fcae0dca87a2022-12-21T20:56:16ZengMDPI AGMolecules1420-30492011-02-011632023203110.3390/molecules16032023Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride CompoundsPetrônio Filgueiras de Athayde-FilhoCledualdo Soares de OliveiraDavid Peter HardingBruno Freitas LiraJorge Gonçalo Fernandes LorenzoJosé Pinto Siqueira-JúniorJosé Maria Barbosa-FilhoVivyanne dos Santos Falcão-SilvaTwo salts of the mesoionic compounds 1,4-diphenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-thiol chloride (MC-1) and 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride (MC-2) were synthesized utilizing 1,4-diphenyl-thiosemicarbazide and 5-nitro-2-furoyl chloride as starting materials. Their structures were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis. These compounds were analyzed for their influence on the effectiveness of norfloxacin, tetracycline, and erythromycin (standard antibiotics) against resistant strains of Staphylococcus aureus. MC-1 and MC-2, at sub-inhibitory concentrations of 16 μg/mL, favourably modulated the antibiotic activity of tetracycline by 16- and 32-fold, respectively (MIC), and that of erythromycin by 4-fold.http://www.mdpi.com/1420-3049/16/3/2023/mesoionic compoundsmodulation of drug resistanceefflux pump inhibitor |
| spellingShingle | Petrônio Filgueiras de Athayde-Filho Cledualdo Soares de Oliveira David Peter Harding Bruno Freitas Lira Jorge Gonçalo Fernandes Lorenzo José Pinto Siqueira-Júnior José Maria Barbosa-Filho Vivyanne dos Santos Falcão-Silva Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds Molecules mesoionic compounds modulation of drug resistance efflux pump inhibitor |
| title | Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds |
| title_full | Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds |
| title_fullStr | Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds |
| title_full_unstemmed | Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds |
| title_short | Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds |
| title_sort | drug resistance modulation in staphylococcus aureus a new biological activity for mesoionic hydrochloride compounds |
| topic | mesoionic compounds modulation of drug resistance efflux pump inhibitor |
| url | http://www.mdpi.com/1420-3049/16/3/2023/ |
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