The importance of the circadian trough in glucocorticoid signaling: a variation on B-flat
Glucocorticoid hormones are essential for health, but overexposure may lead to many detrimental effects, including metabolic, psychiatric, and bone disease. These effects may not only be due to increased overall exposure to glucocorticoids, but also to elevated hormone levels at the time of the phys...
| Main Authors: | , , , |
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| Format: | Article |
| Jezik: | English |
| Izdano: |
Taylor & Francis Group
2023-10-01
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| Serija: | Stress |
| Online dostop: | http://dx.doi.org/10.1080/10253890.2023.2275210 |
| _version_ | 1827595110435520512 |
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| author | Onno C Meijer Sander Kooijman Jan Kroon Elizabeth M Winter |
| author_facet | Onno C Meijer Sander Kooijman Jan Kroon Elizabeth M Winter |
| author_sort | Onno C Meijer |
| collection | DOAJ |
| description | Glucocorticoid hormones are essential for health, but overexposure may lead to many detrimental effects, including metabolic, psychiatric, and bone disease. These effects may not only be due to increased overall exposure to glucocorticoids, but also to elevated hormone levels at the time of the physiological circadian trough of glucocorticoid levels. The late Mary Dallman developed a model which allows the differentiation between the effects of overall 24-hour glucocorticoid overexposure and the effects of a lack of circadian rhythmicity. For this, she continuously treated rats with a low dose of corticosterone (or ‘B’), which leads to a constant hormone level, without 24-hour overexposure using subcutaneously implanted pellets. The data from this ‘B-flat’ model suggest that even modest elevations of glucocorticoid signaling during the time of the normal circadian trough of hormone secretion are a substantial contributor to the negative effects of glucocorticoids on health. |
| first_indexed | 2024-03-09T02:47:05Z |
| format | Article |
| id | doaj.art-29c0316ce2ed48a2ad6a252a52a44d31 |
| institution | Directory Open Access Journal |
| issn | 1025-3890 1607-8888 |
| language | English |
| last_indexed | 2024-03-09T02:47:05Z |
| publishDate | 2023-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Stress |
| spelling | doaj.art-29c0316ce2ed48a2ad6a252a52a44d312023-12-05T16:09:50ZengTaylor & Francis GroupStress1025-38901607-88882023-10-010011110.1080/10253890.2023.22752102275210The importance of the circadian trough in glucocorticoid signaling: a variation on B-flatOnno C Meijer0Sander Kooijman1Jan Kroon2Elizabeth M Winter3Department of Medicine, Division of Endocrinology, Leiden University Medical CenterDepartment of Medicine, Division of Endocrinology, Leiden University Medical CenterDepartment of Medicine, Division of Endocrinology, Leiden University Medical CenterDepartment of Medicine, Division of Endocrinology, Leiden University Medical CenterGlucocorticoid hormones are essential for health, but overexposure may lead to many detrimental effects, including metabolic, psychiatric, and bone disease. These effects may not only be due to increased overall exposure to glucocorticoids, but also to elevated hormone levels at the time of the physiological circadian trough of glucocorticoid levels. The late Mary Dallman developed a model which allows the differentiation between the effects of overall 24-hour glucocorticoid overexposure and the effects of a lack of circadian rhythmicity. For this, she continuously treated rats with a low dose of corticosterone (or ‘B’), which leads to a constant hormone level, without 24-hour overexposure using subcutaneously implanted pellets. The data from this ‘B-flat’ model suggest that even modest elevations of glucocorticoid signaling during the time of the normal circadian trough of hormone secretion are a substantial contributor to the negative effects of glucocorticoids on health.http://dx.doi.org/10.1080/10253890.2023.2275210 |
| spellingShingle | Onno C Meijer Sander Kooijman Jan Kroon Elizabeth M Winter The importance of the circadian trough in glucocorticoid signaling: a variation on B-flat Stress |
| title | The importance of the circadian trough in glucocorticoid signaling: a variation on B-flat |
| title_full | The importance of the circadian trough in glucocorticoid signaling: a variation on B-flat |
| title_fullStr | The importance of the circadian trough in glucocorticoid signaling: a variation on B-flat |
| title_full_unstemmed | The importance of the circadian trough in glucocorticoid signaling: a variation on B-flat |
| title_short | The importance of the circadian trough in glucocorticoid signaling: a variation on B-flat |
| title_sort | importance of the circadian trough in glucocorticoid signaling a variation on b flat |
| url | http://dx.doi.org/10.1080/10253890.2023.2275210 |
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