The Role of Ca<sup>2+</sup>-NFATc1 Signaling and Its Modulation on Osteoclastogenesis
The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription facto...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/10/3646 |
| _version_ | 1797567346679742464 |
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| author | Jung Yun Kang Namju Kang Yu-Mi Yang Jeong Hee Hong Dong Min Shin |
| author_facet | Jung Yun Kang Namju Kang Yu-Mi Yang Jeong Hee Hong Dong Min Shin |
| author_sort | Jung Yun Kang |
| collection | DOAJ |
| description | The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription factor required for osteoclast differentiation. Targeting the various activation processes in osteoclastogenesis provides various therapeutic strategies for bone loss. Diverse compounds that modulate calcium signaling have been applied to regulate osteoclast differentiation and, subsequently, attenuate bone loss. Thus, in this review, we summarized the modulation of the NFATc1 pathway through various compounds that regulate calcium signaling and the calcium influx machinery. Furthermore, we addressed the involvement of transient receptor potential channels in osteoclastogenesis. |
| first_indexed | 2024-03-10T19:40:26Z |
| format | Article |
| id | doaj.art-29c13b906eba409185e989d601ba8c8b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:40:26Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-29c13b906eba409185e989d601ba8c8b2023-11-20T01:14:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012110364610.3390/ijms21103646The Role of Ca<sup>2+</sup>-NFATc1 Signaling and Its Modulation on OsteoclastogenesisJung Yun Kang0Namju Kang1Yu-Mi Yang2Jeong Hee Hong3Dong Min Shin4Department of Oral Biology, Yonsei University College of Dentistry, Seoul 03722, KoreaDepartment of Oral Biology, Yonsei University College of Dentistry, Seoul 03722, KoreaDepartment of Oral Biology, Yonsei University College of Dentistry, Seoul 03722, KoreaDepartment of Physiology, College of Medicine, GAIHST, Gachon University, Incheon 21999, KoreaDepartment of Oral Biology, Yonsei University College of Dentistry, Seoul 03722, KoreaThe increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription factor required for osteoclast differentiation. Targeting the various activation processes in osteoclastogenesis provides various therapeutic strategies for bone loss. Diverse compounds that modulate calcium signaling have been applied to regulate osteoclast differentiation and, subsequently, attenuate bone loss. Thus, in this review, we summarized the modulation of the NFATc1 pathway through various compounds that regulate calcium signaling and the calcium influx machinery. Furthermore, we addressed the involvement of transient receptor potential channels in osteoclastogenesis.https://www.mdpi.com/1422-0067/21/10/3646osteoclastcalcium signalingNFATtransient receptor potential channels |
| spellingShingle | Jung Yun Kang Namju Kang Yu-Mi Yang Jeong Hee Hong Dong Min Shin The Role of Ca<sup>2+</sup>-NFATc1 Signaling and Its Modulation on Osteoclastogenesis International Journal of Molecular Sciences osteoclast calcium signaling NFAT transient receptor potential channels |
| title | The Role of Ca<sup>2+</sup>-NFATc1 Signaling and Its Modulation on Osteoclastogenesis |
| title_full | The Role of Ca<sup>2+</sup>-NFATc1 Signaling and Its Modulation on Osteoclastogenesis |
| title_fullStr | The Role of Ca<sup>2+</sup>-NFATc1 Signaling and Its Modulation on Osteoclastogenesis |
| title_full_unstemmed | The Role of Ca<sup>2+</sup>-NFATc1 Signaling and Its Modulation on Osteoclastogenesis |
| title_short | The Role of Ca<sup>2+</sup>-NFATc1 Signaling and Its Modulation on Osteoclastogenesis |
| title_sort | role of ca sup 2 sup nfatc1 signaling and its modulation on osteoclastogenesis |
| topic | osteoclast calcium signaling NFAT transient receptor potential channels |
| url | https://www.mdpi.com/1422-0067/21/10/3646 |
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